MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress

Biochemical and Biophysical Research Communications

Volumn 399, Issue 3, 2010, Pages 324-330

  Preta, Giulio ^a   de Klark, Rainier ^a   Chakraborti, Shankhamala ^a   Glas, Rickard ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

H2AX; DNA damage response; P38MAPK; Reactive oxygen species; Tripeptidyl peptidase II

Indexed keywords

CISPLATIN; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE II; ETOPOSIDE; FLUOROURACIL; HYDROXYUREA; LINDANE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; DNA DAMAGE; GAMMA IRRADIATION; GAP JUNCTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MELANOMA CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINOPEPTIDASES; ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; CISPLATIN; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; DNA DAMAGE; ETOPOSIDE; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SERINE ENDOPEPTIDASES;

EID: 77956174284     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.06.133     Document Type: Article

References (32)

1. Harrison J.C., Haber J.E. Surviving the breakup: the DNA damage checkpoint. Annu. Rev. Genet. 2006, 40:209-235.
2. von Zglinicki T., Saretzki G., Ladhoff J., d'Adda di Fagagna F., Jackson S.P. Human cell senescence as a DNA damage response. Mech. Ageing Dev. 2005, 126:111-117.
3. Raha S., Robinson B.H. Mitochondria, oxygen free radicals, and apoptosis. Am. J. Med. Genet. 2001, 106:62-70.
4. Pan J.S., Hong M.Z., Ren J.L. Reactive oxygen species: a double-edged sword in oncogenesis. World J. Gastroenterol. 2009, 15:1702-1707.
5. Starkov A.A. The role of mitochondria in reactive oxygen species metabolism and signaling. Ann. NY Acad. Sci. 2008, 1147:37-52.
6. Robinson J.M. Reactive oxygen species in phagocytic leukocytes. Histochem. Cell Biol. 2008, 130:281-297.
7. Klaunig J.E., Kamendulis L.M. The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 2004, 44:239-267.
8. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408:239-247.
9. Bartek J., Bartkova J., Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007, 26:7773-7779.
10. Thornton T.M., Rincon M. Non-classical p38 map kinase functions: cell cycle checkpoints and survival. Int. J. Biol. Sci. 2009, 5:44-51.
11. Reinhardt H.C., Aslanian A.S., Lees J.A., Yaffe M.B. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007, 11:175-189.
12. Reinhardt H.C., Yaffe M.B. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr. Opin. Cell Biol. 2009, 21:245-255.
13. Wood C.D., Thornton T.M., Sabio G., Davis R.A., Rincon M. Nuclear localization of p38MAPK in response to DNA damage. Int. J. Biol. Sci. 2009, 5:428-437.
14. Han J., Sun P. The pathways to tumor suppression via route p38. Trends Biochem. Sci. 2007, 32:364-371.
15. Torres M., Forman H.J. Redox signaling and the MAP kinase pathways. Biofactors 2003, 17:287-296.
16. Cuenda A., Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim. Biophys. Acta 2007, 1773:1358-1375.
17. Rockel B., Peters J., Muller S.A., Seyit G., Ringler P., Hegerl R., Glaeser R.M., Baumeister W. Molecular architecture and assembly mechanism of Drosophila tripeptidyl peptidase II. Proc. Natl. Acad. Sci. USA 2005, 102:10135-10140.
18. Glas R., Bogyo M., McMaster J.S., Gaczynska M., Ploegh H.L. A proteolytic system that compensates for loss of proteasome function. Nature 1998, 392:618-622.
19. Geier E., Pfeifer G., Wilm M., Lucchiari-Hartz M., Baumeister W., Eichmann K., Niedermann G. A giant protease with potential to substitute for some functions of the proteasome. Science 1999, 283:978-981.
20. Gavioli R., Frisan T., Vertuani S., Bornkamm G.W., Masucci M.G. C-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells. Nat. Cell Biol. 2001, 3:283-288.
21. Hong X., Lei L., Glas R. Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis. J. Exp. Med. 2003, 197:1731-1743.
22. Preta G., de Klark R., Glas R. A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses. Biochem. Biophys. Res. Commun. 2009, 389:575-579.
23. Firat E., Tsurumi C., Gaedicke S., Huai J., Niedermann G. Tripeptidyl peptidase II plays a role in the radiation response of selected primary cell types but not based on nuclear translocation and p53 stabilization. Cancer Res. 2009, 69:3325-3331.
24. Wang J., Yi J. Cancer cell killing via ROS: to increase or decrease, that is the question. Cancer Biol. Ther. 2008, 7:1875-1884.
25. Ledirac N., Antherieu S., d'Uby A.D., Caron J.C., Rahmani R. Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive oxygen species. Toxicol. Sci. 2005, 86:444-452.
26. Chiu S.J., Chao J.I., Lee Y.J., Hsu T.S. Regulatiopn of gamma-H2AX and securin contribute to apoptosis by oxaliplatin via a p38 mitogen-activated protein kinase-dependent pathway in human colorectal cancer cells. Toxicol. Lett. 2008, 179:63-70.
27. Perfettini J.L., Castedo M., Nardacci R., Ciccosanti F., Boya P., Roumier T., Larochette N., Piacentini M., Kroemer G. Essential role of p53 phosphorylation by p38MAPK in apoptosis induction by the HIV-1 envelope. J. Exp. Med. 2005, 201:279-289.
28. Bulavin D.V., Saito S., Hollander M.C., Sakaguchi K., Anderson C.W., Appella E., Fornace A.J. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 1999, 18:6845-6854.
29. Gruhne B., Sompallae R., Marescotti D., Kamranvar S.A., Gastaldello S., Masucci M.G. The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species. Proc. Natl. Acad. Sci. USA 2009, 106:2313-2318.
30. Young P.R., McLaughlin M.M., Kumar S., Kassis S., Doyle M.L., McNulty D., Gallagher T.F., Fisher S., McDonnell P.C., Carr S.A., Huddleston M.J., Seibel G., Porter T.G., Livi G.P., Adams J.L., Lee J.C. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 1997, 272:12116-12121.
31. Hong X., Lei L., Künert B., Naredla R., Applequist S.E., Grandien A., Glas R. Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors. Cancer Res. 2007, 67:7165-7174.
32. Sompallae R., Stavropoulou V., Houde M., Masucci M.G. The MAPK signaling cascade is a central hub in the regulation of cell cycle, apoptosis and cytoskeleton remodeling by tripeptidyl-peptidase II. Gene Regul. Syst. Biol. 2008, 2:253-265.