Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: Key role of reactive oxygen species

Toxicological Sciences

Volumn 86, Issue 2, 2005, Pages 444-452

  Ledirac, Nathalie ^a   Antherieu, Sebastian ^a   d'Uby, Anne Dupuy ^a   Caron, Jean Claude ^b   Rahmani, Roger ^a  

^a CEMAGREF   (France)

^b Galderma R and D   (France)

Author keywords

ERK1 2; Keratinocytes; Mitogen activated protein kinases; Organochlorines; Reactive oxygen species; Signal transduction

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ACETYLCYSTEINE; CALPHOSTIN C; DIELDRIN; ENDOSULFAN; GELDANAMYCIN; HEPTACHLOR; LINDANE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; ORGANOCHLORINE INSECTICIDE; PROTEIN C JUN; PROTEIN KINASE C; RAF PROTEIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL LINE; CELL SURVIVAL; FLUORESCEINS; HUMANS; HYDROCARBONS, CHLORINATED; INSECTICIDES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES;

EID: 26444548677     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi192     Document Type: Article

References (40)

1. Andersen, H. R., Vinggaard, A. M., Rasmussen, T. H., Gjermandsen, I. M., and Bonefeld-Jorrgensen, E. C. (2002). Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. [i#Toxicol. Appl. Pharmacol.#1i] [b#179,#1b] 1-12.
2. Ayub, S., Verma, J., and Das, N. (2003). Effect of endosulfan and malathion on lipid peroxidation, nitrite and TNF-α release by rat peritoneal macrophages. [i#Int. Immunopharmacol.#1i] [b#3,#1b] 1819-1828.
3. Bagchi, D., Bagchi, M., Tang, L., and Stohs, S. J. (1997). Comparative in vitro oxygen radical scavenging ability of zinc methionine and selected zinc salts and antioxidants. [i#Toxicol. Lett.#1i] [b#91,#1b] 31-37.
4. Bayoumi, A. E., Perez-Pertejo, Y, Ordonez, C., Reguera, R. M., Balana-Fouce, R., and Ordonez, D. (2000). Changes in the glutathione-redox balance induced by the pesticides heptachlor, chlordane, and toxaphene in CHO-K1 cells. [i#Bull. Environ. Contam. Toxicol.#1i] [b#65,#1b] 748-755.
5. Bedogni, B., O'Neill, M. S., Welford, S. M., Bouley, D. M., Giaccia, A. J., Denko, N. C., and Powell, M. B. (2004). Topical treatment with inhibitors of the phosphatidylinositol 3′-kinase/Akt and Raf/ mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice. [i#Cancer Res.#1i] [b#64,#1b] 2552-2560.
6. Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., and Fusenig, N. E. (1988). Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. [i#J. Cell. Biol.#1i] [b#106,#1b] 761-771.
7. Chang, L., and Karin, M. (2001). Mammalian MAP kinase signalling cascades. [i#Nature#1i] [b#410,#1b] 37-40.
8. Chuang, L. F., and Chuang, R. Y. (1998). Heptachlor and the mitogen-activated protein kinase module in human lymphocytes. [i#Toxicology#1i] [b#128,#1b] 17-23.
9. Chuang, L. F., Rought, S. E., and Chuang, R. Y. (1999). Differential regulation of the major cyclin-dependent kinases, cdk2 and cdc2, during cell cycle progression in human lymphocytes exposed to heptachlor. [i#In Vivo#1i] [b#13,#1b] 455-461.
10. Chung, J. H., Kang, S., Varani, J., Lin, J., Fisher, G. J., and Voorhees, J. J. (2000). Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin [i#in vivo. J. Invest. Dermatol.#1i] [b#115,#1b] 177-182.
11. Delescluse, C., Ledirac, N., de Sousa, G., Pralavorio, M., Lesca, P., and Rahmani, R. (1998) Cytotoxic effects and induction of cytochromes P450 1A1/2 by insecticides, in hepatic or epidermal cells: Binding capability to the Ah receptor. [i#Toxicol. Lett.#1i] [b#96-97,#1b] 33-39.
12. Fautrel, A., Chesne, C., Guillouzo, A., de Sousa, G., Placidi, M., Rahmani, R., Braut, F., Pichon, J., Hoellinger, H., Vintezou, P., [i#et al.#1i] (1991). A multi-laboratory evaluation of cryopreserved monkey hepatocyte functions for use in pharmaco-toxicology. [i#Toxicol. In Vitro#1i] [b#5,#1b] 543-547.
13. Gupta, A., Rosenberger, S. F., and Bowden, G. T. (1999). Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. [i#Carcinogenesis#1i] [b#20,#1b] 2063-2073.
14. Gutkind, J. S. (2000). Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. [i#Sci STKE#1i] [b#40,#1b] re1.
15. Kalantzi, O. I., Hewitt, R., Ford, K. J., Cooper, L., Alcock, R. E., Thomas, G. O., Moris, J. A., McMillan, T. J., and Martin, K. C. (2004). Low dose induction of micronuclei by lindane. [i#Carcinogenesis#1i] [b#25,#1b] 613-622.
16. Kannan, K., and Jain, S. K. (2003). Oxygen radical generation and endosulfan toxicity in Jurkat T-cells. [i#Mol. Cell. Biochem.#1i] [b#247,#1b] 1-7.
17. Kannan, K., Holcombe, R. F., Jain, S. K., Alvarez-Hernandez, X., Chervenak, R., Wolf, R. E., and Glass, J. (2000). Evidence for the induction of apoptosis by endosulfan in a human T-cell leukemic line. [i#Mol. Cell. Biochem.#1i] [b#205,#1b] 53-66.
18. Ledirac, N., Delescluse, C., de Sousa, G., Pralavorio, M., Lesca, P, Amichot, M., Berge, J. B., and Rahmani, R. (1997). Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor. [i#Toxicol. Appl. Pharmacol.#1i] [b#144,#1b] 177-182.
19. Lee, K., and Esselman, W. J. (2002). Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways. [i#Free Radic. Biol. Med.#1i] [b#33,#1b] 1121-1132.
20. Lemaire, G., Terouanne, B., Mauvais, P., Michel, S., and Rahmani, R. (2004). Effect of organochlorine pesticides on human androgen receptor activation [i#in vitro. Toxicol. Appl. Pharmacol.#1i] [b#196,#1b] 235-246.
21. Levinthal, D. J., and Defranco, D. B. (2005). Reversible oxidation of ERK-directed protein phosphatases drives oxidative toxicity in neurons. [i#J. Biol. Chem.#1i] [b#280,#1b] 5875-5883.
22. Lonsway, J. A., Byers, M. E., Dowla, H. A., Panemangalore, M., and Antonious, G. F. (1997). Dermal and respiratory exposure of mixers/ sprayers to acephate, methamidophos, and endosulfan during tobacco production. [i#Bull. Environ. Contam. Toxcicol.#1i] [b#52,#1b] 179-186.
23. Magwere, T., Naik, Y. S., and Hasler, J. A. (1997). Primaquine alters antioxidant enzyme profiles in rat liver and kidney. [i#Free Radic. Res.#1i] [b#27,#1b] 173-179.
24. Martindale, J. L., and Holbrook, N. J. (2002). Cellular response to oxidative stress: Signaling for suicide and survival. [i#J. Cell. Physiol.#1i] [b#192,#1b] 1-15.
25. Monick, M. M., Carter, A. B., Flaherty, D. M., Peterson, M. W., and Hunninghake, G. W. (2000). Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. [i#J. Immunol.#1i] [b#165,#1b] 4632-4639.
26. Monsour, S. A. (2004). Pesticide exposure - Egyptian scene. [i#Toxicology#1i] [b#198#1b], 91-115.
27. Moser, G. J., and Smart, R. C. (1989). Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity. [i#Carcinogenesis#1i] [b#10,#1b] 851-856.
28. Myhre, O., Andersen, J. M., Aarnes, H., and Fonnum, F. (2003). Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. [i#Biochem. Pharmacol.#1i] [b#65,#1b] 1575-1582.
29. Okoumassoun, L. E., Averill-Bates, D., Marion, M., and Denizeau, F. (2003). Possible mechanisms underlying the mitogenic action of heptachlor in rat hepatocytes. [i#Toxicol. Appl. Pharmacol.#1i] [b#193,#1b] 356-369.
30. Persson, C., Sjoblom, T., Groen, A., Kappert, K., Engstrom, U., Hellman, U., Heldin, C. H., den Hertog, J., and Ostman, A. (2004). Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. [i#Proc. Natl. Acad. Sci. U.S.A.#1i] [b#101,#1b] 1886-1891.
31. Reed, A., Dzon, L., Loganathan, B. G., and Whalen, M. M. (2004). Immunomodulation of human natural killer cell cytotoxic function by organochlorine pesticides. [i#Hum. Exp. Toxicol.#1i] [b#23,#1b] 463-471.
32. Rought, S. E., Yau, P. M., Guo, X. W., Chuang, L. F., Doi, R. H., Chuang, R. Y. (2000). Modulation of CPP32 activity and induction of apoptosis in Human CEM × 174 lymphocytes by heptachlor, a chlorinated hydrocarbon insecticide. [i#J. Biochem. Mol. Toxicol.#1i] [b#14,#1b] 42-50.
33. Saiyed, H., Dewan, A., Bhatnagar, V., Shenoy, U., Shenoy, R., Rajmohan, H., Patel, K., Kashyap, R., Kulkarni, P., Rajan, B., [i#et al.#1i] (2003). Effect of endosulfan on male reproductive development. [i#Environ. Health Perspect.#1i] [b#111,#1b] 1958-1962.
34. Sajan, M. P., Standaert, M. L., Bandyopadhyay, G., Quon, M. J., Burke, T. R., Jr., and Farese, R. V. (1999). Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes. [i#J. Biol. Chem.#1i] [b#274,#1b] 30495-30500.
35. Schönwasser, D. C., Marais, R. M., Marshall, C. J., and Parker, P. J. (1998). Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, atypical protein kinase C isotypes. [i#Mol. Cell. Biol.#1i] [b#18,#1b] 790-798.
36. Schulte, T. W., Blagosklonny, M. V., Romanova, L., Mushinski, J. F., Monia, B. P., Johnston, J. F., Nguyen, P., Trepel, J., and Neckers, L. M. (1996). Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway. [i#Mol. Cell. Biol.#1i] [b#16,#1b] 5839-5845.
37. Scippo, M. L., Argiris, C., Van De Weerdt, C., Muller, M., Willemsen, P., Martial, J., and Maghuin-Rogister, G. (2004). Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. [i#Anal. Bioanal. Chem.#1i] [b#378,#1b] 664-669.
38. Steinmetz, R., Young, P. C., Caperell-Grant, A., Gize, F. A., Madhukar, B. V., Ben-Jonathan, N., Bigsby, R. M. (1996). Novel estrogenic action of the pesticide residue beta-hexachlorocyclohexane in human breast cancer cells. [i#Cancer Res.#1i] [b#56,#1b] 5403-5409.
39. Takahashi, H., Ibe, M., Nakamura, S., Ishida-Yamamoto, A., Hasimoto, Y., and Iizuka, H. (2002). Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis. [i#J. Dermatol. Sci.#1i] [b#30,#1b] 94-99.
40. Zou, E., and Matsumura, F. (2003). Long-term exposure to beta-hexachlor-ocyclohexane (beta-HCH) promotes transformation and invasiveness of MCF-7 human breast cancer cells. [i#Biochem. Pharmacol.#1i] [b#66,#1b] 831-840.