Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5552-5558

  Mony, Laetitia ^a,b   Triballeau, Nicolas ^a,c,d   Paoletti, Pierre ^b   Acher, Francine C ^a   Bertrand, Hugues Olivier ^c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b PSL RESEARCH UNIVERSITY   (France)

^c Parc Club Orsay Universite   (France)

^d Galapagos SASU   (France)

Author keywords

Glutamate; NMDA; NR2B selective antagonist; Pharmacophore; Virtual screening

Indexed keywords

1 (3,4 DICHLOROPHENYL) 3 AZABICYCLO[3.1.0]HEXANE; DESIPRAMINE; DOPAMINE TRANSPORTER; FLUOXETINE; NOMIFENSINE; NORADRENALIN TRANSPORTER; PROPANOLAMINE DERIVATIVE; SEROTONIN TRANSPORTER; TRIPLE REUPTAKE INHIBITOR; VENLAFAXINE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DOPAMINE UPTAKE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; NORADRENALIN UPTAKE; RAT; SEROTONIN UPTAKE; STEREOCHEMISTRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANQUILIZING ACTIVITY;

ANIMALS; DATABASES, FACTUAL; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 77956173275     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.043     Document Type: Article

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