NR2B selective NMDA antagonists: The evolution of the ifenprodil-type pharmacophore

Current Topics in Medicinal Chemistry

Volumn 6, Issue 7, 2006, Pages 687-695

  Borza, István ^a   Domány, György ^a  

^a GEDEON RICHTER LTD   (Hungary)

Author keywords

Ifenprodil; NR2B subunit; Pharmacophore; Piperidines; Side activities

Indexed keywords

2 BENZOXAZOLONE DERIVATIVE; 4 [3 [4 (4 FLUOROPHENYL) 1,2,3,6 TETRAHYDRO 1 PYRIDINYL] 2 HYDROXYPROPOXY]BENZAMIDE; 4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; AMIDE; BENZIMIDAZOLE DERIVATIVE; BESONPRODIL; CHROMAN DERIVATIVE; CI 1041; CO 101071; CO 101244; CO 101677; DILVAX; EMD 95885; HYDANTOIN DERIVATIVE; IFENPRODIL; IFENPRODIL TARTRATE; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PD 174494; PIPERIDINE DERIVATIVE; PRAZOSIN; RO 63 1908; RO 67 8867; TRAXOPRODIL; UNCLASSIFIED DRUG;

ADRENERGIC ACTIVITY; BINDING AFFINITY; BINDING KINETICS; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENANTIOMER; IC 50; IN VITRO STUDY; IN VIVO STUDY; NEUROPATHIC PAIN; NONHUMAN; PARKINSON DISEASE; PHARMACOPHORE; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; PIPERIDINES; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646537447     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802606776894456     Document Type: Review

References (41)

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