Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes

Molecular Microbiology

Volumn 77, Issue 5, 2010, Pages 1237-1245

  Wang, Qiao Ping ^a,b   Kawahara, Taemi ^a   Horn, David ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CHROMATIN; ENZYME LOCALIZATION; GENE EXPRESSION; GENE SILENCING; NONHUMAN; PRIORITY JOURNAL; TELOMERE; TRYPANOSOMA BRUCEI;

GENE EXPRESSION REGULATION; GENE SILENCING; HISTONE DEACETYLASES; PROTOZOAN PROTEINS; TRYPANOSOMA BRUCEI BRUCEI; VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA;

HEXAPODA; PROTOZOA; TRYPANOSOMA BRUCEI;

EID: 77956133527     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2010.07284.x     Document Type: Article

References (35)

1. Alsford, S. Horn, D. (2008) Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei. Mol Biochem Parasitol 161 : 76 79.
2. Alsford, S., Kawahara, T., Glover, L. Horn, D. (2005) Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects. Mol Biochem Parasitol 144 : 142 148.
3. Alsford, S., Kawahara, T., Isamah, C. Horn, D. (2007) A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation. Mol Microbiol 63 : 724 736.
4. Bougdour, A., Maubon, D., Baldacci, P., Ortet, P., Bastien, O., Bouillon, A., et al. (2009) Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites. J Exp Med 206 : 953 966.
5. Corona, D.F., Clapier, C.R., Becker, P.B. Tamkun, J.W. (2002) Modulation of ISWI function by site-specific histone acetylation. EMBO Rep 3 : 242 247.
6. De Ruijter, A.J.M., Van Gennip, A.H., Caron, H.N., Kemp, S. Van Kuilenburg, A.B.P. (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370 : 737 749.
7. DeRubertis, F., Kadosh, D., Henchoz, S., Pauli, D., Reuter, G., Struhl, K. Spierer, P. (1996) The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384 : 589 591.
8. Doheny, J.G., Mottus, R. Grigliatti, T.A. (2008) Telomeric position effect - a third silencing mechanism in eukaryotes. PLoS One 3 : e3864.
9. Drummond, D.C., Noble, C.O., Kirpotin, D.B., Guo, Z.X., Scott, G.K. Benz, C.C. (2005) Clinical development of histone deacetylase inhibitors as anticancer agents. Annu Rev Pharmacol 45 : 495 528.
10. Figueiredo, L.M. Cross, G.A. (2010) Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes. Eukaryot Cell 9 : 148 154.
11. Figueiredo, L.M., Janzen, C.J. Cross, G.A.M. (2008) A histone methyltransferase modulates antigenic variation in African trypanosomes. PloS Biol 6 : 1539 1548.
12. Figueiredo, L.M., Cross, G.A.M. Janzen, C.J. (2009) Epigenetic regulation in African trypanosomes: a new kid on the block. Nat Rev Microbiol 7 : 504 513.
13. Finnin, M.S., Donigian, J.R., Cohen, A., Richon, V.M., Rifkind, R.A., Marks, P.A., et al. (1999) Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 401 : 188 193.
14. Glover, L. Horn, D. (2006) Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres. EMBO Rep 7 : 93 99.
15. Glover, L., Alsford, S., Beattie, C. Horn, D. (2007) Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. Nucleic Acids Res 35 : 872 880.
16. Groth, A., Rocha, W., Verreault, A. Almouzni, G. (2007) Chromatin challenges during DNA replication and repair. Cell 128 : 721 733.
17. Hertz-Fowler, C., Figueiredo, L.M., Quail, M.A., Becker, M., Jackson, A., Bason, N., et al. (2008) Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei. PloS One 3 : e3527.
18. Horn, D. (2007) Introducing histone modification in trypanosomes. Trends Parasitol 23 : 239 242.
19. Horn, D. (2008) Histone deacetylases. Drug Targets Kinetoplastid Parasites 625 : 81 86.
20. Horn, D. (2009) Antigenic Variation: Extending the Reach of Telomeric Silencing. Curr Biol 19 : R496 R498.
21. Horn, D. Cross, G.A.M. (1997) Analysis of Trypanosoma brucei vsg expression site switching in vitro. Mol Biochem Parasitol 84 : 189 201.
22. Hughes, K., Wand, M., Foulston, L., Young, R., Harley, K., Terry, S., et al. (2007) A novel ISWI is involved in VSG expression site downregulation in African trypanosomes. EMBO J 26 : 2400 2410.
23. Ingram, A.K. Horn, D. (2002) Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression. Mol Microbiol 45 : 89 97.
24. Jeppesen, P. Turner, B.M. (1993) The Inactive X-Chromosome in Female Mammals Is Distinguished by a Lack of Histone-H4 Acetylation, a Cytogenetic Marker for Gene-Expression. Cell 74 : 281 289.
25. Kawahara, T., Siegel, T.N., Ingram, A.K., Alsford, S., Cross, G.A.M. Horn, D. (2008) Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes. Mol Microbiol 69 : 1054 1068.
26. Kouzarides, T. (2007) Chromatin modifications and their function. Cell 128 : 693 705.
27. Melville, S.E., Leech, V., Navarro, M. Cross, G.A. (2000) The molecular karyotype of the megabase chromosomes of Trypanosoma brucei stock 427. Mol Biochem Parasitol 111 : 261 273.
28. Pays, E. (2005) Regulation of antigen gene expression in Trypanosoma brucei. Trends Parasitol 21 : 517 520.
29. Rundlett, S.E., Carmen, A.A., Kobayashi, R., Bavykin, S., Turner, B.M. Grunstein, M. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci USA 93 : 14503 14508.
30. Siegel, T.N., Hekstra, D.R., Kemp, L.E., Figueiredo, L.M., Lowell, J.E., Fenyo, D., et al. (2009) Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei. Genes Dev 23 : 1063 1076.
31. Stanne, T.M. Rudenko, G. (2010) Active VSG expression sites in Trypanosoma brucei are depleted of nucleosomes. Eukaryot Cell 9 : 136 147.
32. Vanhamme, L., Pays, E., McCulloch, R. Barry, J.D. (2001) An update on antigenic variation in African trypanosomes. Trends Parasitol 17 : 338 343.
33. Yang, X.J. Seto, E. (2008) The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 9 : 206 218.
34. Yang, X.F., Figueiredo, L.M., Espinal, A., Okubo, E. Li, B. (2009) RAP1 Is Essential for Silencing Telomeric Variant Surface Glycoprotein Genes in Trypanosoma brucei. Cell 137 : 99 109.
35. Zhou, J., Zhou, B.O., Lenzmeier, B.A. Zhou, J.Q. (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res 37 : 3699 3713.