Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone

Molecular Endocrinology

Volumn 24, Issue 9, 2010, Pages 1805-1821

  Granell, Susana ^a   Mohammad, Sameer ^a   Ramanagoudr Bhojappa, Ramanagouda ^a   Baldini, Giulia ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYL BUTYRIC ACID; BUTYRIC ACID DERIVATIVE; CCAAT ENHANCER BINDING PROTEIN; MELANOCORTIN 4 RECEPTOR; UBIQUITIN ACTIVATING ENZYME 1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ARTICLE; CELL IMMORTALIZATION; CELL SURFACE; CONTROLLED STUDY; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; HUMAN; HUMAN CELL; NERVE CELL; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; UBIQUITINATION;

CELL LINE, TUMOR; CELL MEMBRANE; CYCLIC AMP; ENDOPLASMIC RETICULUM; HUMANS; MUTANT PROTEINS; MUTATION; OBESITY; PHENYLBUTYRATES; PROTEIN FOLDING; RECEPTOR, MELANOCORTIN, TYPE 4; RECOMBINANT FUSION PROTEINS; UBIQUITINATION; UNFOLDED PROTEIN RESPONSE;

EID: 77956123768     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0071     Document Type: Article

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