Inhibition of Ras/ERK1/2 signaling protects against postischemic renal injury

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 6, 2006, Pages

  Sabbatini, Massimo ^a,c   Santillo, Mariarosaria ^a,b   Pisani, Antonio ^a   Paternò, Roberto ^a   Uccello, Francesco ^a   Serù, Rosalba ^a   Matrone, Gianfranco ^a   Spagnuolo, Gianrico ^a   Andreucci, Michele ^a   Serio, Vittorio ^a   Esposito, Pasquale ^a   Cianciaruso, Bruno ^a   Fuiano, Giorgio ^a   Avvedimento, Enrico V ^b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c Univ Federico II of Naples ^*  (Italy)

Author keywords

Endothelium; Farnesyl transferase inhibitors; Kidney; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CHAETOMELLIC ACID A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PENTOBARBITAL; PHENOBARBITAL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE B; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; DRUG INHIBITION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; KIDNEY CELL; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY TUBULE CELL; KIDNEY TUBULE NECROSIS; MALE; NEPHRECTOMY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 33744781526     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00304.2005     Document Type: Article

References (28)

1. Baer PC, Nockher WA, Haase W, and Scherberich JE. Isolation of proximal and distal tubule cells from human kidney by immunomagnetic separation. Kidney Int 52: 1321-1331, 1997.
2. Bonventre JV and Zuk A. Ischemic acute renal failure: an inflammatory disease? Kidney Int 66: 480-485, 2004.
3. Cuda G, Paternò R, Ceravolo R, Candigliota M, Perrotti N, Perticone F, Faniello MC, Schepis F, Ruocco A, Mele E, Cassano S, Bifulco M, Santillo M, and Avvedimento EV. Protection of human endothelial cells from oxidative stress. Role of Ras-ERK1/2 signalling. Circulation 105: 968-974, 2002.
4. Daemen MA, van't Veer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M, Vandenabeele P, and Buurman WA. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 104: 541-549, 1999.
5. Detrisac CJ, Sens MA, Garvin AJ, Spicer SS, and Sens DA. Tissue culture of human kidney epithelial cells of proximal tubule origin. Kidney Int 25: 383-390, 1984.
6. Doi K, Suzuki Y, Nakao A, Fujita T, and Noiri E. Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. Kidney Int 65: 1714-1723, 2004.
7. Du Bose TD Jr, Warnock DG, Meht RL, Bonventre JV, Hammerman MR, Molitoris BA, Paller MS, Siegel NJ, Scherbenske J, and Striker GE. Acute renal failure in the 21st century: recommendations for management and outcomes assessment. Am J Kidney Dis 29: 793-799, 1998.
8. Fischer MA, Gransier TJ, Beckers LM, Bekers O, Bast A, and Haenen GR. Determination of the antioxidant capacity in blood. Clin Chem Lab Med 43: 735-740, 2005.
9. James GL, Goldstein JL, and Brown MS. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J Biol Chem 270: 6221-6226, 1995.
10. Kelly KJ, Plotkin Z, and Dagher PC. Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury. J Clin Invest 108: 1291-1298, 2001.
11. Lowry OH, Rosbrough NJ, Farr AL, and Randall RJ. Protein measurement with the Folin-phenol reagents. J Biol Chem 193: 265-275, 1951.
12. Lu CY, Penfield JG, Kielar ML, Vasquez MA, and Jeyarajah DR. Hypothesis: is renal allograft rejection initiated by the response to injury during the transplant process? Kidney Int 55: 2157-2168, 1999.
13. Magee T and Marshall C. New insights into the interaction of Ras with the plasma membrane. Cell 98: 9-12, 1999.
14. Marshall CJ. Ras effectors. Curr Opin Cell Biol 8: 197-204, 1996.
15. Matsumoto M, Makino Y, Tanaka T, Tanaka H, Ishikaza H, Noiri E, Fujita T, and Nangaku M. Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol 14: 1825-1832, 2003.
16. Ojo AO, Wolfe RA, Held PJ, Port FK, and Schmouder RL. Delayed graft function: risk factors and implications for renal allograft survival. Transplantation 63: 1620-1628, 1997.
17. Paller MS, Hoidal JR, and Ferris TF. Oxygen free radicals in ischemic acute renal failure in the rat J. Clin Invest 74: 1156-1164, 1984.
18. Sabbatini M, Pisani A, Uccello F, Serio V, Serù R, Paternò R, Cianciaruso B, Fuiano G, and Andreucci M. Atorvastatin improves the course of ischemic acute renal failure in aging rats. J Am Soc Nephrol 15: 901-909, 2004.
19. Sabbatini M, Sansone G, Uccello F, De Nicola L, Giliberti A, Sepe V, Magri P, Conte G, and Andreucci VE. Functional versus structural changes in the pathophysiology of acute ischemic renal failure in aging rats. Kidney Int 45: 1355-1361, 1994.
20. Santillo M, Mondola P, Serù R, Annella T, Cassano S, Ciullo I, Tecce MF, Iacomino G, Damiano S, Cuda G, Paternò R, Martignetti V, Mele E, Feliciello A, and Avvedimento EV. Opposing functions of Ki- and Ha-Ra genes in the regulation of redox signals. Curr Biol 11: 614-619, 2001.
21. Sebti SM and Adjei AA. Farnesyltransferase inhibitors. Semin Oncol 29: 3-39, 2004.
22. Serù R, Mondola P, Damiano S, Svegliati S, Agnese S, Avvedimento EV, and Santillo M. HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway. J Neurochem 91: 613-622, 2004.
23. Svegliati S, Cancello R, Sambo P, Luchetti M, Paroncini P, Orlandini G, Discepoli G, Paterno R, Santillo M, Cuozzo C, Cassano S, Avvedimento EV, and Gabrielli A. Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts. J Biol Chem 280: 36474-36482.
24. Thadhani R, Pacual M, and Bonventre JV. Acute renal failure. N Engl J Med 334: 1448-1460, 1996.
25. Thiemermann C, Patel NSA, Kvale EO, Cockerill GW, Brown PAJ, Stewart KN, Cuzzocrea S, Britti D, Mota-Filipe H, and Chatterjee PK. High density lipoprotein (HDL) reduces renal ischemia/reperfusion injury. J Am Soc Nephrol 14: 1833-1843, 2003.
26. Torras J, Cruzado JM, Riera M, Condom E, Duque Herrero I, Merlos M, Espinosa L, Lloberas N, Egido J, and Grinyo JM. Long-term-protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. Kidney Int 56: 1798-1808, 1999.
27. Vitelli R, Santillo M, Lattero D, Chiariello M, Bifulco M, Bruni CB, and Bucci C. Role of the small GTPase Rab7 in the late endocytic pathway. J Biol Chem 272: 4391-4397, 1997.
28. Waskiewicz AJ and Cooper JA. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol 7: 798-805, 1995.