Activation of MEK 1/2 and p42/44 MAPK by angiotensin II in hepatocyte nucleus and their potentiation by ethanol

Alcohol

Volumn 43, Issue 4, 2009, Pages 315-322

  Aroor, Annayya R ^a   Lee, Youn Ju ^a   Shukla, Shivendra D ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

Angiotensin II; Ethanol; Hepatocytes; MAPK kinase; Mitogen activated protein kinase; Nuclear translocation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALCOHOL; ANGIOTENSIN II; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL LEVEL; CELL STIMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; INCUBATION TIME; LIVER CELL NUCLEUS; MALE; NONHUMAN; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; DRUG SYNERGISM; ENZYME ACTIVATION; ETHANOL; HEPATOCYTES; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 67649114487     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2009.04.001     Document Type: Article

References (54)

1. Adachi T., Nakashima S., Saji S., Nakamura T., and Nozawa Y. Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: involvement of protein tyrosine kinase and protein kinase C. Hepatology 23 (1996) 1244-1253
2. Adachi T., Kar S., Wang M., and Carr B.I. Transient and sustained ERK phosphorylation and nuclear translocation in growth control. J. Cell. Physiol. 192 (2002) 151-159
3. Aroor A.R., and Shukla S.D. MAP kinase signaling in diverse effects of ethanol. Life. Sci. 74 (2004) 2339-2364
4. Bataller R., Gabel E., Parsons C.J., Morris T., Yang L., Schoonhoven R., et al. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology 41 (2005) 1046-1055
5. 2+ fluxes and phosphorylase activity in liver. Meth. Enzymol. 109 (1985) 550-558
6. Brasier A.R., Jamaluddin M., Han Y., Patterson C., and Runge M.S. Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor. Mol. Cell. Biochem. 212 (2000) 155-169
7. Brunet A., Roux D., Lenormand P., Dowd S., Keyse S., and Pouyssegur J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J. 18 (1999) 664-674
8. Chen R.H., Sarnecki C., and Blenis J. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol. Cell. Biol. 12 (1992) 915-927
9. Chen J., Ishac E.J.N., Dent P., Kunos G., and Gao B. Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver. Biochem. J. 334 (1998) 669-676
10. Collins G.B., Brosnihan K.B., Zuti R.A., Messina M., and Gupta M.K. Neuroendocrine, fluid balance, and thirst responses to alcohol in alcoholics. Alcohol. Clin. Exp. Res. 16 (1992) 228-233
11. 2α. J. Cell. Physiol. 168 (1996) 608-617
12. Deitrich R.A., and Harris R.A. How much alcohol should I use in my experiments?. Alcohol. Clin. Exp. Res. 20 (1996) 1-2
13. Dey A., and Cederbaum A.I. Alcohol and oxidative liver injury. Hepatology 43 (2006) S63-S74
14. Fukuda M., Gotoh Y., and Nishida E. Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J. 16 (1997) 1901-1908
15. Godeny M.D., and Sayeski P.P. Ang II-induced cell proliferation is dually mediated by c-Src/Yes/Fyn-regulated ERK1/2 activation in the cytoplasm and PKCzeta-controlled ERK1/2 activity within the nucleus. Am. J. Physiol. Cell Physiol. 291 (2006) C1297-C1307
16. Goetze S., Xi X., Graf K., Fleck E., Hsueh W.A., and Law R.E. Troglitazone inhibits angiotensin II-induced extracellular signal-regulated kinase 1/2 nuclear translocation and activation in vascular smooth muscle cells. FEBS Lett. 452 (1999) 277-282
17. González-Espinosa C., and García-Sáinz J.A. Angiotensin II and active phorbol esters induce proto-oncogene expression in isolated rat hepatocytes. Biochim. Biophys. Acta 1136 (1992) 309-314
18. Hongo S., Watanabe T., Takahashi K., and Miyazaki A. Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. J. Cell. Biochem. 98 (2006) 185-193
19. Katz M., Amit I., and Yarden Y. Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim. Biophys. Acta 1773 (2007) 1161-1176
20. Kawanaka H., Tomikawa M., Jones M.K., Szabo I.L., Pai R., Baatar D., et al. Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications. Hepatology 34 (2001) 990-999
21. Kim S., and Kahn C.R. Insulin regulation of mitogen-activated protein kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression. Biochem. J. 323 (1997) 621-627
22. Lee Y.J., and Shukla S.D. Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. Eur. J. Pharmacol. 508 (2005) 31-45
23. Lee Y.J., and Shukla S.D. Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde. Eur. J. Pharmacol. 573 (2008) 29-38
24. Lieber C.S. Biochemical and molecular basis of alcohol-induced injury to liver and other tissues. N. Engl. J. Med. 319 (1988) 1639-1650
25. Mandl M., Slack D.N., and Keyse S.M. Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5. Mol. Cell. Biol. 25 (2005) 1830-1845
26. McKillop I.H., Vyas N., Schmidt C.M., Cahill P.A., and Sitzmann J.V. Enhanced Gi-protein-mediated mitogenesis following chronic ethanol exposure in a rat model of experimental hepatocellular carcinoma. Hepatology 29 (1999) 412-420
27. McAllister-Lucas L.M., Ruland J., Siu K., Jin X., Gu S., Kim D.S., et al. CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. Proc. Natl. Acad. Sci. USA. 104 (2007) 139-144
28. Menice C.B., Hulvershorn J., Adam L.P., Wang C.L.A., and Morgan K.G. Calponin and mitogen-activated protein kinase signaling in differentiated vascular smooth muscle. J. Biol. Chem. 272 (1997) 25157-25161
29. Mizukami Y., Kobayashi S., Überall F., Hellbert K., Kobayashi N., and Yoshida K. Nuclear mitogen-activated protein kinase activation by protein kinase Cζ during reoxygenation after ischemic hypoxia. J. Biol. Chem. 275 (2000) 19921-19927
30. Nguyen V.A., and Gao B. Expression of interferon alfa signaling components in human alcoholic liver disease. Hepatology 35 (2002) 425-432
31. Owens D.M., and Keyse S.M. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 26 (2007) 3203-3213
32. Park P.H., Lim R.W., and Shukla S.D. Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression. Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2005) 1124-1136
33. Park P.H., Aroor A.R., and Shukla S.D. Role of Ras in ethanol modulation of angiotensin II activated p42/p44 MAP kinase in rat hepatocytes. Life. Sci. 79 (2006) 2357-2363
34. Qiao L., Yacoub A., Studer E., Gupta S., Pei X.Y., Grant S., et al. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 35 (2002) 779-789
35. Reddy M.A., and Shukla S.D. Potentiation of mitogen-activated protein kinase by ethanol in embryonic liver cells. Biochem. Pharmacol. 51 (1996) 661-668
36. Reddy M.A., and Shukla S.D. Nuclear activation and translocation of mitogen-activated protein kinases modulated by ethanol in embryonic liver cells. Biochim. Biophys. Acta 1497 (2000) 271-278
37. Rosseland C.M., Wierød L., Oksvold M.P., Werner H., Ostvold A.C., Thoresen G.H., et al. Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes. Hepatology 42 (2005) 200-207
38. Schulman I.H., Zhou M.S., and Raij L. Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans. Hypertension 49 (2007) 270-271
39. Seglen P.O. Preparation of isolated rat liver cells. Methods Cell Biol. 13 (1976) 29-83
40. Shukla S.D., Lee Y.J., Park P., and Aroor A.R. Acetaldehyde alters MAP kinase signaling and epigenetic histone modifications in hepatocytes. In: Chadwick D.J., and Goode J. (Eds). Acetaldehyde Related Pathology: Bridging the Trans-disciplinary Divide (Novartis Foundation Symposium) (2007), John Wiley & Sons, New Jersey 217-228
41. Tolwinski N.S., Shapiro P.S., Goueli S., and Ahn N.G. Nuclear localization of mitogen-activated protein kinase kinase 1 (MKK1) is promoted by serum stimulation and G2-M progression. Requirement for phosphorylation at the activation lip and signaling downstream of MKK. J. Biol. Chem. 274 (1999) 6168-6174
42. Tombes R.M., Auer K.L., Mikkelsen R., Valerie K., Wymann M.P., Marshall C.J., et al. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. Biochem. J. 330 (1998) 1451-1460
43. Traverse S., Gomez S., Paterson H., Marshall C., and Cohen P. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288 (1992) 351-355
44. Turjanski A.G., Vaque J.P., and Gutkind J.S. MAP kinases and the control of nuclear events. Oncogene 26 (2007) 3240-3253
45. Venugopal S.K., Chen J., Zhang Y., Clemens D., Follenzi A., and Zern M.A. Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells. J. Biol. Chem. 282 (2007) 31900-31908
46. Wang Y., Schramek H., and Dunn M.J. Cytosolic and nuclear mitogen-activated protein kinases are regulated by distinct mechanisms. Exp. Cell. Res. 225 (1996) 382-388
47. Weng Y.I., and Shukla S.D. Ethanol alters angiotensin II stimulated mitogen activated protein kinase in hepatocytes: agonist selectivity and ethanol metabolic independence. Eur. J. Pharmacol. 398 (2000) 323-333
48. Weng Y.I., and Shukla S.D. Angiotensin II activation of focal adhesion kinase and pp60c-Src in relation to mitogen-activated protein kinases in hepatocytes. Biochim. Biophys. Acta 1589 (2002) 285-297
49. Weng Y.I., and Shukla S.D. Effects of chronic ethanol treatment on the angiotensin II-mediated p42/p44 mitogen-activated protein kinase and phosphorylase a activation in rat hepatocytes. Alcohol 29 (2003) 83-90
50. 727 STAT 3 phosphorylation in cultured rat hepatocytes: relevance to activation of p42/44 mitogen activated protein kinase. Alcohol 42 (2008) 397-406
51. Whitehurst A., Cobb M.H., and White M.A. Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Mol. Cell. Biol. 24 (2004) 10145-10150
52. Whitmarsh A.J. Regulation of gene transcription by mitogen-activated protein kinase signaling pathways. Biochim. Biophys. Acta 1773 (2007) 1285-1298
53. Zebisch A., Czernilofsky A.P., Keri G., Smigelskaite J., Sill H., and Troppmair J. Signaling through RAS-RAF-MEK-ERK: from basics to bedside. Curr. Med. Chem. 14 (2007) 601-623
54. Zima T., and Kalousova M. Oxidative stress and signal transduction pathways in alcoholic liver disease. Alcohol. Clin. Exp. Res. 29 (2005) 110S-115S