Ethanol potentiates the acute fatty infiltration of liver caused by burn injury: Prevention by insulin treatment

Journal of Burn Care and Research

Volumn 30, Issue 3, 2009, Pages 482-488

  Emanuele, Nicholas V ^a,b,c   Emanuele, Mary Ann ^a,b   Morgan, Michelle O ^d   Sulo, Denise ^b   Yong, Sheri ^e   Kovacs, Elizabeth J ^b,d   Himes, Ryan D ^b   Callaci, John J ^b  

^a Departments of Medicine   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Departments of Surgery   (United States)

^e Depart of Pathology   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; GLUCOSE; INSULIN GLARGINE; SODIUM CHLORIDE; INSULIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE MODEL; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; INSULIN TREATMENT; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; SHAM PROCEDURE; TREATMENT OUTCOME; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; C57BL MOUSE;

ALANINE TRANSAMINASE; ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BURNS; ETHANOL; FATTY LIVER; INSULIN; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL;

EID: 67849086808     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e3181a28df3     Document Type: Article

References (18)

1. McGill V, Kowal-Vern A, Fisher SG, Kahn S, Gamelli RL. The impact of substance use on mortality and morbidity from thermal injury. J Trauma 1995;38:931-934.
2. Nelson S, Kolls JK. Alcohol, host defense and society. Nat Rev Immuno 2002;2:205.
3. Kowal-Vern A, Walenga JM, Hoppensteadt D, Sharp-Pucci M, Gamelli RL. Interleukin-2 and interleukin-6 in relation to burn wound size in the acute phase of thermal injury. J Am Coll Surg 1994;178:357-362.
4. Emanuele M, Emanuele N, Gamelli R, Kovacs E, Lapaglia N. Effects of insulin on hepatic inflammation induced by ethanol and burn injury in a murine model of critical illness. J Burn Care Res 2007;28:490-499.
5. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Eng J Med 2001;8: 183-192.
6. Dandona P, Aljada A, Mohanty P. The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm. Diabetologia 2002;45:924-930.
7. Fonseca VA. The effects of insulin on the endothelium. En-docrinol Metab Clin North Am 2007;2(Suppl):20-26.
8. Faunce D, Gregory M, Kovacs E. Effects of acute ethanol exposure on cellular immune responses in a murine model of thermal injury. J Leukoc Biol 1997;62:733-740.
9. Gomez CR, Nomellini V, Baila H, Oshima K, Kovacs EJ. Effects of aging and interleukin-6 on hepatic injury after systemic inflammation in response to lipopolysaccharide. Shock 2009;31:178-184.
10. Messingham KA, Faunce DE, Kovacs EJ. Alcohol, injury, and cellular immunity. Alcohol 2002;2:137-149.
11. Choudhry MA, Chaudry IH. Alcohol intoxication and post-burn complications. Front Biosci 2006;11:998-1005.
12. Barret J, Jeschke M, Herndon D. Fatty infiltration of the liver in severely burned pediatric patients: autopsy findings and clinical implications. J Trauma 2001;51:736-739.
13. Browning J, Horton J. Molecular mediators of hepatic ste-atosis and liver injury. J Clin Investig 2004;114:147-152.
14. Diehl A, Li Z, Lin H, Yang S. Cytokines and the pathogenesis of non-alcoholic steatohepatitis. Gut 2005;54:303-306.
15. McCullough A. Pathophysiology of nonalcoholic steato-hepatitis. J Clin Gastroenterol 2006;40:S17-29.
16. MacSween R, Burst A, Portman B, Ishak K, Scheuer P, Anthony P. Pathology of the liver. 4th ed. Toronto: Churchill Livingstone; 2002. 134 p.
17. Daughtery CC, Gartside PS, Heubi JE, Saalfeld K, Synder J. A morphometric study of Reye's syndrome. Correlation of reduced mitochondrial numbers and increased mitochondrial size with clinical manifestations. Am J Pathol 1987;129: 313-326.
18. Malmberg K; DIGAMI Study Group. Prospective randomized study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ 1997;314:1512-1515.