MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300

EMBO Journal

Volumn 22, Issue 2, 2003, Pages 281-291

  Li, Qi Jing ^b   Yang, Shen Hsi ^a   Maeda, Yutaka ^b   Sladek, Frances M ^b   Sharrocks, Andrew D ^b   Martins Green, Manuela ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NONE

Author keywords

Chemokine; Co activators; Elk 1; P300; Transcription activation

Indexed keywords

CHEMOKINE; HISTONE ACETYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P300; SERINE; TRANSCRIPTION FACTOR ETS 1;

ANIMAL CELL; ARTICLE; CHICK EMBRYO; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; EARLY RESPONSE GENE; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GENE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ACETYLTRANSFERASES; ANIMALS; CHICK EMBRYO; DNA-BINDING PROTEINS; ENZYME INHIBITORS; ETS-DOMAIN PROTEIN ELK-1; FIBROBLASTS; HISTONE ACETYLTRANSFERASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; THROMBIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA; CERVUS ELAPHUS;

EID: 0037439199     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg028     Document Type: Article

References (31)

1. Avantaggiati, M.L., Ogryzko, V., Gardner, K., Giordano, A., Levine, A.S. and Kelly, K. (1997) Recruitment of p300/CBP in p53-dependent signal pathways. Cell, 89, 1175-1184.
2. Chawla, S., Hardingham, G.E., Quinn, D.R. and Bading, H. (1998) CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science, 281, 1505-1509.
3. Chen, C.-J., Deng, A., Kim, A., Blobel, G. and Lieberman, P. (2001) Stimulation of CREB binding protein nucleosomal histone acetyltransferase activity by a class of transcriptional activators. Mol. Cell. Biol., 21, 476-487.
4. Gille, H., Kortenjann, M., Thomae, O., Moomaw, C., Slaughter, C., Cobb, M.H. and Shaw, P.E. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J., 14, 951-962.
5. Herrera, R.E., Shaw, P.E. and Nordheim, A. (1989) Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction. Nature, 340, 68-70.
6. Hu, S.C., Chrivia, J. and Ghosh, A. (1999) Regulation of CBP-mediated transcription by neuronal calcium signaling. Neuron, 22, 799-808.
7. Janknecht, R. and Hunter, T. (1996) Transcription. A growing coactivator network. Nature, 383, 22-23.
8. Janknecht, R. and Nordheim, A. (1996) MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem. Biophys. Res. Commun., 228, 831-837.
9. Janknecht, R., Ernst, W.H., Pingoud, V. and Nordheim, A. (1993) Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J., 12, 5097-5104.
10. Jiang, G., Nepomuceno, L., Hopkins, K. and Sladek, F.M. (1995) Exclusive homodimerizaiton of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol. Cell. Biol., 15, 5131-5143.
11. Kung, A.L., Rebel, V.I., Bronson, R.T., Ch'ng, L.E., Sieff, C.A., Livingston, D.M. and Yao, T.P. (2000) Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev., 14, 272-277.
12. Li, Q., Vaingankar, S.M., Green, H.M. and Martins-Green, M. (1999) Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk-1 transcription factor. J. Biol. Chem., 274, 15454-15465.
13. Li, Q.J., Vaingankar, S., Sladek, F.M. and Martins-Green, M. (2000) Novel nuclear target for thrombin: activation of the Elk-1 transcription factor leads to chemokine gene expression. Blood, 96, 3696-3706.
14. Martins-Green, M. and Feugate, J. (1998) The 9E3/CEF4 gene product is a chemotactic and angiogenic factor that can initiate the wound-healing cascade in vivo. Cytokine, 10, 522-535.
15. Nissen, L.J., Gelly, J.C. and Hipskind, R.A. (2001) Induction-independent recruitment of CREB-binding protein to the c-fos serum response element through interactions between the bromodomain and Elk-1. J. Biol. Chem., 276, 5213-5221.
16. Rao, V.N., Huebner, K., Isobe, M., ar-Rushdi, A., Croce, C.M. and Reddy, E.S. (1989) elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science, 244, 66-70.
17. Soutoglou, E., Viollet, B., Vaxillaire, M., Yaniv, M., Pontoglio, M. and Talianidis, I. (2001) Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity. EMBO J., 20, 1984-1992.
18. Sgambato, V., Pages, C., Rogard, M., Besson, M.J. and Caboche, J. (1998) Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation. J. Neurosci., 18, 8814-8825.
19. Shang, Y., Hu, X., DiRenzo, J., Lazar, M. and Brown, M. (2000) Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell, 103, 843-852.
20. Sharrocks, A.D. (1995) ERK2/p42 MAP kinase stimulates both autonomous and SRF-dependent DNA binding by Elk-1. FEBS Lett., 368, 77-80.
21. Taatjes, D.J., Naar, A.M., Andel, F., 3rd, Nogales, E. and Tjian, R. (2002) Structure, function and activator-induced conformations of the CRSP coactivator. Science, 295, 1058-1062.
22. Vaingankar, S.M. and Martins-Green, M. (1998) Thrombin activation of the 9E3/CEF4 chemokine involves tyrosine kinases including c-src and the epidermal growth factor receptor. J. Biol. Chem., 273, 5226-5234.
23. Vo, N. and Goodman, R.H. (2001) CREB-binding protein and p300 in transcriptional regulation. J. Biol. Chem., 276, 13505-13508.
24. Xu, L. et al. (1998) Signal-specific co-activator domain requirements for Pit-1 activation. Nature, 395, 301-306.
25. Xu, L., Glass, C.K. and Rosenfeld, M.G. (1999) Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev., 9, 140-147.
26. Yang, S., Yates, P., Whitmarsh, A., Davis, R. and Sharrocks, A. (1998a) The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Mol. Cell. Biol., 18, 710-720.
27. Yang, S., Whitmarsh, A., Davis RJ, Sharrocks AD. (1998b) Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J., 17, 1740-1749.
28. Yang, S., Shore, P., Willingham, N., Lakey, J. and Sharrocks, A. (1999) The mechanism of phosphorylation-inducible activation of the ets-domain transcription factor Elk-1. EMBO J., 18, 5666-5674.
29. Yang, S., Vickers, E., Brehm, A., Kouzarides, T., Sharrocks, A. (2001) Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1. Mol. Cell. Biol., 21, 2802-2814.
30. Yao, T.P. et al. (1998) Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell, 93, 361-372.
31. Yuan, W., Condorelli, G., Caruso, M., Felsani, A. and Giordano, A. (1996) Human p300 protein is a coactivator for the transcription factor MyoD. J. Biol. Chem., 271, 9009-9013.