Psychosocial stress in tree shrews: Clomipramine counteracts behavioral and endocrine changes

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 1, 1996, Pages 219-228

  Fuchs, Eberhard ^a   Kramer, Marian ^a   Hermes, Birgit ^b   Netter, Petra ^b   Hiemke, Christoph ^b  

^a GERMAN PRIMATE CENTER   (Germany)

^b NONE

Author keywords

antidepressant; cortisol; depression; grooming; HPA axis; locomotor activity; marking behavior; norepinephrine; risk assessment

Indexed keywords

CLOMIPRAMINE; DRUG METABOLITE; HYDROCORTISONE; NORADRENALIN; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; BEHAVIOR; CONFERENCE PAPER; CONTROLLED STUDY; DEPRESSION; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; ENDOCRINE SYSTEM; GROOMING; INSECTIVORE; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PSYCHOSOCIAL ENVIRONMENT; RISK ASSESSMENT; STRESS; URINARY EXCRETION;

EID: 0029939345     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02166-3     Document Type: Conference Paper

References (58)

1. Aue, D. Konfrontationen zwischen männlichen Spitzhörnchen (Tupaia belangeri). Konsequenzen der Sozialkontakte für Verhalten und Physiologie sowie der Einfluss individueller und äusserer Faktoren auf die Dominanzentscheidung. Thesis, Göttingen; 1988.
2. Bohus, B.; Benus, R. F.; Fokkema, D. S.; Koolhaas, J. M.; Nyakas, C.; Van Oortmerssen, G. A.; Prins, A. J. A.; de Ruiter, A. J. H.; Scheurink, A. J. W.; Steffens, A. B. Neuroendocrine states and behavioral and physiological stress responses. Prog. Brain. Res. 72:57-70; 1987.
3. Checkley, S. Neuroendocrine mechanisms and the precipitation of depression by life events. Br. J. Psychiatry 60(Suppl. 15):7-17; 1992.
4. Dimsdale, J. E.; Ziegler, M. G. What do plasma and urinary measures of catecholamines tell us about the human response to stress? Circulation 83(Suppl. 2):II-36-II-42; 1991.
5. Dunn, A. J.; Berridge, C. W. Physiological and behavioral responses to corticotropin-releasing factor administration: Is CRF a mediator of anxiety or stress responses? Brain Res. Rev. 15:71-100; 1990.
6. Eichenbaum, H.; Otto, T. The hippocamous - What does it to do? Behav. Neural Biol. 57:2-36; 1992.
7. Fischer, H. D.; Heinzeller, T.; Raab, A. Gonadal responses to psychosocial stress in male tree shrews (Tupaia belangeri). Morphometry of testis, epididymis and prostate. Andrologia 17:262-275; 1985.
8. 1A-receptors under psychosocial stress. J. Neurosci. 15:7132-7140; 1995.
9. 3H]rauwolscine binding sites in the brains of male tree shrews are related to social status. Brain Res. 597:131-137; 1992.
10. Fokkema, D. S.; Koolhaas, J. M. Acute and conditioned blood pressure changes in relation to social status and psychosocial stimuli in rats. Physiol. Behav. 34:33-38; 1985.
11. Fuchs, E. Activity of the sympatho-adrenomedullary system in male (Tupaia belangeri) under control and stress situations. In: Usdin, E.; Kvetnansky, R.; Axelrod, J., eds. Stress - The role of catecholamines and other neurotransmitters. Vol. 1. London: Gordon and Breach; 1984:595-602.
12. Fuchs, E.; Kleinknecht, S. The influence of chronic social confrontation on oxygen consumption of Tupaia belangeri under resting conditions. Z. Säugetierkunde 51:55-57; 1986.
13. Fuchs, E.; Schumacher, M. Psychosocial stress affects pineal function in the tree shrew (Tupaia belangeri). Physiol. Behav. 47: 713-717; 1990.
14. Fuchs, E.; Jöhren, O.; Goldberg, M. Psychosocial stress affects urinary pteridines in tree shrews. Naturwissenschaften 79:379-381; 1992.
15. Fuchs, E.; Jöhren, O.; Flügge, G. Psychosocial conflict in the tree shrew: Effects on sympathoadrenal activity and blood pressure. Psychoneuroendocrinology 18:557-565; 1993.
16. Fuchs, E.; Flügge, G. Modulation of binding sites for corticotropin-releasing hormone by chronic psychosocial stress. Psychoneuroendocrinology 20:33-51; 1994.
17. Fuchs, E.; Uno, H.; Flügge, G. Chronic psychosocial stress induces morphological alterations in hippocampal pyramidal neurons of the tree shrew. Brain Res. 673:275-282; 1995.
18. Golden, R. N.; Markey, S. P.; Risby, E. D.; Rudorfer, M. V.; Cowdry, R. W.; Potter, W. Z. Antidepressants reduce wholebody NE turnover while enhancing 6-hydroxymelatonin output. Arch. Gen. Psychiatry 45:150-154; 1988.
19. Härtter, S.; Hiemke, C. Column switching and high-performance liquid chromatography in the analysis of amitriptyline, nortriptilyne and hydroxylated metabolites in human plasma or serum. J. Chromatogr. 578:273-282; 1992.
20. Härtter, S.; Arand, M.; Oesch, F., Hiemke, C. Noncompetitive inhibition of clomipramine N-demethylation by fluvoxamine. Psychopharmacology (Berlin) 117:149-153; 1995.
21. Henry, J. P.; Stephens, P. M. Stress, health, and the social environment. Berlin: Springer-Verlag; 1977.
22. Herman, J.; Watson, S.; Chao, H.; Coirini, H.; McEwen, B. S. Diurnal regulation of glucocorticoid receptor and mineralocorticoid receptor mRNAs in rat hippocampus. Mol. Cell. Neurosci. 4:181-190; 1993.
23. Heydorn, W. E.; Brunswick, D. J.; Frazer, A. Effect of treatment of rats with antidepressants on melatonin concentrations in the pineal gland and serum. J. Pharmacol. Exp. Ther. 222:534-543; 1982.
24. Holsboer, F.; Doerr, H. G.; Gerken, A.; Müller, O. A.; Sippell, W. G. Cortisol, 11-deoxycortisol, and ACTH concentrations after dexamethasone in depressed patients and healthy volunteers. Psychiatr. Res. 11:15-23; 1983.
25. Holsboer, F.; Spengler, D.; Heuser, I. The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. Prog. Brain Res. 93:385-417; 1992.
26. Jacobson, L.; Sapolsky, R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr. Rev. 12:118-134; 1991.
27. Jöhren, O.; Topp, H.; Sander, G.; Schöch, G.; Fuchs, E. Social stress in tree shrews increases the whole-body RNA degeneration rates. Naturwissenschaften 78:36-38; 1991.
28. Jöhren, O.; Flügge, G.; Fuchs, E. Hippocampal glucocorticoid receptor expression in the tree shrew: Regulation by psychosocial conflict. Cell. Mol. Neurobiol. 14:281-296; 1994.
29. Khansari, D. N.; Murgo, A. J.; Faith, R. E. Effects of stress on the immune system. Immunol. Today 11:170-175; 1990.
30. Magariños, A. M.; McEwen, B. S.; Flügge, G.; Fuchs, E. Apical dendritic atrophy of hippocampal CA3 region in subordinate tree shrews after chronic psychosocial stress: A Golgi study. J. Neurosci. (in press).
31. Martin, R. D. Reproduction and ontogeny in tree shrews (Tupaia belangeri), with references to their general behavior and taxonomic relationships. Z. Tierpsychol. 4:409-529; 1968.
32. Martin, R. D. Primate origins and evolution. London: Chapman and Hall; 1990.
33. McTavish, D.; Benfield, P. Clomipramine: An overview of its pharmacological properities and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39:136-153; 1990.
34. Moleman, P.; Tulen, J. H. M.; Blankestijn, P. J.; Man in't Veld, A. J.; Boomsma, F. Urinary excretion of catecholamines and their metabolites in relation to circulating catecholamines. Arch. Gen. Psychiatry 49:568-572; 1992.
35. Musselman, D. L.; Nemeroff, C. B. Adrenal function in major depression. Endocrinologist 5:91-96; 1995.
36. Owens, M. J.; Nemeroff, C. B. Physiology and pharmacology of corticotropin-releasing hormone. Pharmacol. Rev. 43:425-473; 1991.
37. Paykel, E. S. Contribution of life events to causation of psychiatric illness. Psychol. Med. 8:245-253; 1978.
38. Peiffer, A.; Veilleux, S.; Barden, N. Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in the rat brain. Psychoneuroendocrinology 16:505-515; 1991.
39. Raab, A. Der Serotoninstoffwechsel in einzelnen Hirnteilen vom Tupaia (Tupaia belangeri) bei soziopsychischem Stress. Z. Physiol. 72:54-66; 1971.
40. Raab, A.; Storz, H. A longterm study on the impact of sociopsychic stress in tree-shrews (Tupaia belangeri) on central and peripheral tyrosine hydroxylase activity. J. Comp. Physiol. 108: 115-131; 1976.
41. Reul, J. M. H. M.; Stec, I.; Söder, M.; Holsboer, F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology 133:312-320; 1993.
42. A inhibitor moclobemide. Neuroendocrinology 60:509-519; 1994.
43. Rubin, R. T.; Poland, R. E.; Lesser, I. M.; Winston, R. A.; Blodgett, N. Neuroendocrine aspects of primary endogenous depression. I. Cortisol secertory dynamics in patients and matched controls. Arch. Gen. Psychiatry 44:328-336; 1987.
44. Sachar, E. J.; Hellman, L.; Roffwarg, H. P.; Halpern, F. S.; Fukush, D. K.; Gallagher, T. F. Disrupted 24 hour patterns of cortisol secretion in psychotic depressives. Arch. Gen. Psychiatry 28:19-24; 1973.
45. Shen, Y.; Specht, S. M.; De Saint Ghislain, I.; Li, R. The hippocampus: A biological model for studying learning and memory. Prog. Neurobiol. 44:485-496; 1994.
46. Sprankel, H.; Richarz, K. Nicht-reproduktives Verhalten von (Tupaia glis) Diard, 1820 im raum-zeitlichen Bezug. Z. Säugetierkunde 41:77-101; 1976.
47. Spruijt, B. M.; van Hooff, J. A. R. A. M.; Gispen, W. H. The ethology and neurobiology of grooming behaviour. Physiol. Rev. 72:825-852; 1992.
48. Stöhr, W. Heart rate of tree shrews and its persistent modification by social contact. In: Schmidt, T. H.; Dembroski, T. M.; Blümchen, G., eds. Biological factors in cardiovascular disease. Berlin: Springer Verlag; 1986:492-499.
49. Stout, S. C.; Nemroff, C. B. Stress and psychiatric disorders. Semin. Neurosci. 6:271-280; 1994.
50. Tilders, F. J. H.; Berkenbosch, F. CRF and catecholamines; Their place in the central and peripheral regulation of the stress response. Acta Endocrinol. Suppl. 276:63-75; 1986.
51. 125I]-labeled ligands. Proc. Natl. Acad. Sci. USA 82:8672-8676; 1985.
52. Usdin, E.; Asberg, M.; Bertilsson, L.; Sjöquist, F. Frontiers in biochemical and pharmacological research in depression. Adv. Biochem. Psychopharmacol. 39:1984.
53. van Erp, A. M. M.; Kruk, M. R.; Meelis, W.; Willekens-Bramer, D. C. Effect of environmental Stressors on time course, variability and form of self-grooming in the rat: Handling, social contact, defeat, novelty, restraint and fur moistening. Behav. Brain Res. 65:47-55; 1994.
54. von Holst, D.; Buergel-Goodwin, U. Chinning by male (Tupaia belangeri): The effects of scent marks of conspecifics and of other species. J. Comp. Physiol. 103:153-171; 1975.
55. von Holst, D.; Lesk, S. Über den Informationsgehalt des Sternaldrüsensekretes männlicher und weiblicher (Tupaia belangeri). J. Comp. Physiol. 103:173-188; 1975.
56. von Holst, D.; Fuchs, E.; Stöhr, W. Physiological changes in male Tupaia belangeri under different types of social stress. In: Dembroski, T. M.; Schmidt, T. H.; Blümchen, G., eds. Biobehavioral bases of coronary heart disease. Basel: Karger; 1983: 382-390.
57. Weiner, H. Perturbing the organism. The biology of stressful experience. Chicago: University of Chicago Press: 1992.
58. Willner, P.; Muscat, R.; Papp, M. Chronic mild stress-induced anhedonia: A realistic animal model of depression. Neurosci. Biobehav. Rev. 16:525-534; 1992.