The α2A-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety

Journal of Neuroscience

Volumn 21, Issue 13, 2001, Pages 4875-4882

  Schramm, Nicole L ^a   McDonald, Michael P ^a   Limbird, Lee E ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenergic receptor; Antidepressant; Anxiety; Forced swim; Imipramine; Light dark test

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; IMIPRAMINE; NORADRENALIN; SEROTONIN; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL BEHAVIOR; ANIMAL MODEL; ANXIETY; ARTICLE; DEPRESSION; FEMALE; FORCED SWIMMING TEST; KNOCKOUT MOUSE; MALE; MOOD; MOUSE; NONHUMAN; NORADRENALIN RELEASE; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; REARING; SEROTONIN RELEASE;

EID: 0035399969     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-13-04875.2001     Document Type: Article

References (59)

1. Single-unit response of noradrenergic neurons in the locus ceruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli
2. Single-unit response of noradrenergic neurons in the locus ceruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli
3. Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice
4. Effects of propranolol, buspirone, pCPA, reserpine, and chlordiazepoxide on open-field behavior
5. The biology of being frazzled
6. Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation
7. Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists
8. Noradrenergic innervation of serotonergic neurons in the dorsal raphe: Demonstration by electron microscopic autoradiography
9. Behavioral, neuroendocrine and serotonergic consequences of single social defeat and repeated fluoxetine pretreatment in the Lewis rat strain
10. mCPP-induced anxiety in the light-dark box in rats - A new method for screening anxiolytic activity
11. Noradrenergic alpha-2 receptor agonists reverse memory deficits induced by the anxiogenic drug, FG7142, in rats
12. Metabolism of norepinephrine, serotonin and dopamine in rat brain with stress
13. Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: Evidence that this model identifies anxiolytic-like activity
14. Alpha 2-adrenoceptor blockade prevents the effect of desipramine in the forced swimming test
15. Monoamine dysfunction and the pathophysiology and treatment of depression
16. Neurobiological mechanisms in human anxiety. Evidence supporting central noradrenergic hyperactivity
17. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
18. Experimental anxiety and antidepressant drugs: The effects of moclobemide, a selective reversible MAO-A inhibitor, fluoxetine and imipramine in mice
19. Do noradrenaline and serotonin differentially affect social motivation and behaviour?
20. Noradrenaline-selective versus serotonin-selective antidepressant therapy: Differential effects on social functioning
21. Functional classification of antidepressants based on antagonism of swim stress induced fos-like immunoreactivity
22. A new approach to the light/dark test procedure in mice
23. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission
24. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice
25. Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice
26. Interaction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat
27. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
28. Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715)
29. Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog
30. Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c
31. The use of a plus-maze to measure anxiety in the mouse
32. Central hypotensive effects of the alpha2a-adrenergic receptor subtype
33. Stress and cognitive function
34. Sex differences in open-field behavior in response to the beta-carboline FG 7142 in rats
35. S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity
36. 2-adrenoceptors: II. Influence on monoaminergic transmission, motor function, and anxiety in comparison with dexmedetomidine and clonidine
37. 5-HT1A receptor antagonists neither potentiate nor inhibit the effects of fluoxetine and befloxatone in the forced swim test in rats
38. Sudden darkness induces a high activity-low anxiety state in male and female rats
39. Acute cold-restraint stress affects alpha 2-adrenoceptors in specific brain regions of the rat
40. Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei
41. Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test
42. Neural adaptation in imipramine-treated rats processed in forced swim test: Assessment of time course, handling, rat strain and amine uptake
43. Behavioral despair in mice: A primary screening test for antidepressants
44. Behavioural despair in rats: A new model sensitive to antidepressant treatments
45. "Behavioural despair" in rats and mice: Strain differences and the effects of imipramine
46. Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala
47. Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
48. Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test
49. Insights from in vivo modification of adrenergic receptor gene expression
50. Alpha-adrenoceptors
51. Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels
52. Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike?
53. The modified light/dark transition test in mice: Evaluation of classic and putative anxiolytic and anxiogenic drugs
54. Reversal of behavioral depression by infusion of an alpha-2 adrenergic agonist into the locus ceruleus
55. D3 dopamine receptor-deficient mouse: Evidence for reduced anxiety
56. Effect of repeated novel stressors on depressive behavior and brain norepinephrine receptor system in Sprague-Dawley and Wistar Kyoto (WKY) rats
57. Thigmotaxis as a test for anxiolytic activity in rats
58. Infusion of adrenergic receptor agonists and antagonists into the locus ceruleus and ventricular system of the brain: Effects on swim-motivated and spontaneous motor activity
59. Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors