Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 21, 2009, Pages 7593-7605

  Silverman, Richard B ^a   Lawton, Graham R ^a   Ranaivo, Hantamalala Ralay ^a   Chico, Laura K ^a   Seo, Jiwon ^a   Watterson, D Martin ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Amide prodrug; Amine prodrug; Azide prodrug; Blood brain barrier; Carbamate prodrug; Neuronal nitric oxide synthase; Neuronal nitric oxide synthase inhibitor; Organic azide; Prodrug

Indexed keywords

AMIDE; AMINE; AZIDE; CARBAMIC ACID; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PRODRUG; ENZYME INHIBITOR;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFECT; DRUG PENETRATION; EX VIVO STUDY; IN VITRO STUDY; MOUSE; NONHUMAN; SURFACE CHARGE; ANIMAL; BRAIN; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; LIVER MICROSOME; METABOLISM; NERVE CELL; SYNTHESIS;

AMINES; ANIMALS; AZIDES; BLOOD-BRAIN BARRIER; BRAIN; ENZYME INHIBITORS; MICE; MICROSOMES, LIVER; NEURONS; NITRIC OXIDE SYNTHASE TYPE I; PRODRUGS;

EID: 73949086818     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.065     Document Type: Article

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