Roles of cysteine proteases in tumor progression: Analysis of cysteine cathepsin knockout mice in cancer models

The Cancer Degradome: Proteases and Cancer Biology

Volumn , Issue , 2008, Pages 281-304

  Reinheckel, Thomas ^a   Gocheva, Vasilena ^b   Peters, Christoph ^a   Joyce, Johanna A ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77955950794     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-69057-5_15     Document Type: Chapter

References (100)

1. Adachi, W., Kawamoto, S., Ohno, I., Nishida, K., Kinoshita, S., Matsubara, K., and Okubo, K. 1998. Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. Invest Ophthalmol Vis Sci 39(10): 1789-1796
2. Almholt, K., Lund, L.R., Rygaard, J., Nielsen, B.S., Dano, K., Romer, J., and Johnsen, M. 2005. Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice. Int J Cancer 113(4): 525-532
3. Arbeit, J.M., Munger, K., Howley, P.M., and Hanahan, D. 1994. Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol 68(7): 4358-4368
4. Authier, F., Kouach, M., and Briand, G. 2005. Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B. FEBS Lett 579(20): 4309-4316
5. Bell-McGuinn, K.M., Garfall, A.L., Bogyo, M., Hanahan, D., and Joyce, J.A. 2007. Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res 67(15): 7378-7385
6. Bervar, A., Zajc, I., Sever, N., Katunuma, N., Sloane, B.F., and Lah, T.T. 2003. Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors. Biol Chem 384(3): 447-455
7. Brown, J., Matutes, E., Singleton, A., Price, C., Molgaard, H., Buttle, D., and Enver, T. 1998. Lymphopain, a cytotoxic T and natural killer cell-Associated cysteine proteinase. Leukemia 12 (11): 1771-1781
8. Buck, M.R., Karustis, D.G., Day, N.A., Honn, K.V., and Sloane, B.F. 1992. Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues. Biochem J 282(Pt 1): 273-278
9. Carmeliet, P., and Jain, R.K. 2000. Angiogenesis in cancer and other diseases. Nature 407(6801): 249-257
10. Castiglioni, T., Merino, M.J., Elsner, B., Lah, T.T., Sloane, B.F., and Emmert-Buck, M.R. 1994. Immunohistochemical analysis of cathepsins D, B, and L in human breast cancer. Hum Pathol 25(9): 857-862
11. Cavallaro, U., and Christofori, G. 2004. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4(2): 118-132
12. Cheng, T., Hitomi, K., van Vlijmen-Willems, I.M., de Jongh, G.J., Yamamoto, K., Nishi, K., Watts, C., Reinheckel, T., Schalkwijk, J., and Zeeuwen, P.L. 2006. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem 281(23): 15893-15899
13. Coulombe, R., Grochulski, P., Sivaraman, J., Menard, R., Mort, J.S., and Cygler, M. 1996. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. Embo J 15(20): 5492-5503
14. Coussens, L.M., Hanahan, D., and Arbeit, J.M. 1996. Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice. Am J Pathol 149(6): 1899-1917
15. Cygler, M., Sivaraman, J., Grochulski, P., Coulombe, R., Storer, A.C., and Mort, J.S. 1996. Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion. Structure 4(4): 405-416
16. de Visser, K.E., Eichten, A., and Coussens, L.M. 2006. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6(1): 24-37
17. Deussing, J., Kouadio, M., Rehman, S., Werber, I., Schwinde, A., and Peters, C. 2002. Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Genomics 79(2): 225-240
18. Drake, F.H., Dodds, R.A., James, I.E., Connor, J.R., Debouck, C., Richardson, S., Lee-Rykaczewski, E., Coleman, L., Rieman, D., Barthlow, R., Hastings, G., and Gowen, M. 1996. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem 271(21): 12511-12516
19. Ebert, M.P., Kruger, S., Fogeron, M.L., Lamer, S., Chen, J., Pross, M., Schulz, H.U., Lage, H., Heim, S., Roessner, A., Malfertheiner, P., and Rocken, C. 2005. Overexpression of cathepsin B in gastric cancer identified by proteome analysis. Proteomics 5(6): 1693-1704
20. Eeckhout, Y., and Vaes, G. 1977. Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation. Biochem J 166(1): 21-31
21. Felbor, U., Dreier, L., Bryant, R.A., Ploegh, H.L., Olsen, B.R., and Mothes, W. 2000. Secreted cathepsin L generates endostatin from collagen XVIII. Embo J 19(6): 1187-1194
22. Felbor, U., Kessler, B., Mothes, W., Goebel, H.H., Ploegh, H.L., Bronson, R.T., and Olsen, B.R. 2002. Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A 99(12): 7883-7888
23. Ferreras, M., Felbor, U., Lenhard, T., Olsen, B.R., and Delaisse, J. 2000. Generation and degradation of human endostatin proteins by various proteinases. FEBS Lett 486(3): 247-251
24. Foghsgaard, L., Wissing, D., Mauch, D., Lademann, U., Bastholm, L., Boes, M., Elling, F., Leist, M., and Jaattela, M. 2001. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol 153(5): 999-1010
25. Friedrichs, B., Tepel, C., Reinheckel, T., Deussing J., von Figura, K., Herzog, V., Peter, C., Saftig, P., Brix, K., 2003. Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest. 111 (11): 1733-1745
26. Frohlich, E., Schlagenhauff, B., Mohrle, M., Weber, E., Klessen, C., and Rassner, G. 2001. Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma. Cancer 91(5): 972-982
27. Fujise, N., Nanashim, A., Taniguchi, Y., Matsuo, S., Hatano, K., Matsumoto, Y., Tagawa, Y., and Ayabe, H. 2000. Prognostic impact of cathepsin B and matrix metalloproteinase-9 in pulmonary adenocarcinomas by immunohistochemical study. Lung Cancer 27(1): 19-26
28. Gadea, B.B., and Joyce, J.A. 2006. Tumour-host interactions: implications for developing anticancer therapies. Expert Rev Mol Med 8(30): 1-32
29. Gocheva, V., and Joyce, J.A. 2007. Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle 6(1): 60-64
30. Gocheva, V., Zeng, W., Ke, D., Klimstra, D., Reinheckel, T., Peters, C., Hanahan, D., and Joyce, J. A. 2006. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev 20 (5): 543-556
31. Goretzki, L., Schmitt, M., Mann, K., Calvete, J., Chucholowski, N., Kramer, M., Gunzler, W.A., Janicke, F., and Graeff, H. 1992. Effective activation of the proenzyme form of the urokinasetype plasminogen activator (pro-uPA) by the cysteine protease cathepsin L. FEBS Lett 297(1-2): 112-118
32. Goulet, B., Baruch, A., Moon, N.S., Poirier, M., Sansregret, L.L., Erickson, A., Bogyo, M., and Nepveu, A. 2004. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell 14(2): 207-219
33. Guicciardi, M.E., Deussing, J., Miyoshi, H., Bronk, S.F., Svingen, P.A., Peters, C., Kaufmann, S. H., and Gores, G.J. 2000. Cathepsin B contributes to TNF-Alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 106(9): 1127-1137
34. Guicciardi, M.E., Miyoshi, H., Bronk, S.F., and Gores, G.J. 2001. Cathepsin B knockout mice are resistant to tumor necrosis factor-Alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications. Am J Pathol 159(6): 2045-2054
35. Guinec, N., Dalet-Fumeron, V., and Pagano, M. 1993. In vitro study of basement membrane degradation by the cysteine proteinases, cathepsins B, B-like and L. Digestion of collagen IV, laminin, fibronectin, and release of gelatinase activities from basement membrane fibronectin. Biol Chem Hoppe Seyler 374(12): 1135-1146
36. Guo, M., Mathieu, P.A., Linebaugh, B., Sloane, B.F., and Reiners, J.J., Jr. 2002. Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factorbetaL a process initiated by the exocytosis of cathepsin B. J Biol Chem 277(17): 14829-14837
37. Guy, C.T., Cardiff, R.D., and Muller, W.J. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12(3): 954-961
38. Halangk, W., Lerch, M.M., Brandt-Nedelev, B., Roth, W., Ruthenbuerger, M., Reinheckel, T., Domschke, W., Lippert, H., Peters, C., and Deussing, J. 2000. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 106(6): 773-781
39. Hanahan, D. 1985. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315(6015): 115-122
40. Hanahan, D., and Folkman, J. 1996. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86(3): 353-364
41. Harbeck, N., Alt, U., Berger, U., Kruger, A., Thomssen, C., Janicke, F., Hofler, H., Kates, R.E., and Schmitt, M. 2001. Prognostic impact of proteolytic factors (urokinase-type plasminogen activator, plasminogen activator inhibitor 1, and cathepsins B, D, and L) in primary breast cancer reflects effects of adjuvant systemic therapy. Clin Cancer Res 7(9): 2757-2764
42. Ishidoh, K., and Kominami, E. 1995. Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitro. Biochem Biophys Res Commun 217(2): 624-631
43. Jedeszko, C., and Sloane, B.F. 2004. Cysteine cathepsins in human cancer. Biol Chem 385(11): 1017-1027
44. Joyce, J.A., Baruch, A., Chehade, K., Meyer-Morse, N., Giraudo, E., Tsai, F.Y., Greenbaum, D.C., Hager, J.H., Bogyo, M., and Hanahan, D. 2004. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5(5): 443-453
45. Kopitar-Jerala, N. 2006. The role of cystatins in cells of the immune system. FEBS Lett 580(27): 6295-6301
46. Kos, J., Stabuc, B., Schweiger, A., Krasovec, M., Cimerman, N., Kopitar-Jerala, N., and Vrhovec, I 1997. Cathepsins B, H, and L and their inhibitors stefin A and cystatin C in sera of melanoma patients. Clin Cancer Res 3(10): 1815-1822
47. Lah, T.T., Buck, M.R., Honn, K.V., Crissman, J.D., Rao, N.C., Liotta, L.A., and Sloane, B.F. 1989. Degradation of laminin by human tumor cathepsin B. Clin Exp Metastasis 7(4): 461-468
48. Lah, T.T., Cercek, M., Blejec, A., Kos, J., Gorodetsky, E., Somers, R., and Daskal, I 2000. Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators. Clin Cancer Res 6(2): 578-584
49. Lecaille, F., Kaleta, J., and Bromme, D. 2002. Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design. Chem Rev 102(12): 4459-4488
50. Lechner, A.M., Assfalg-Machleidt, I., Zahler, S., Stoeckelhuber, M., Machleidt, W., Jochum, M., and Nagler, D.K. 2006. RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-Adhesive properties. J Biol Chem 281(51): 39588-39597
51. Liotta, L.A., and Kohn, E.C. 2001. The microenvironment of the tumour-host interface. Nature 411(6835): 375-379
52. Liu, Y., Xiao, S., Shi, Y., Wang, L., Ren, W., and Sloane, B.F. 1998. Cathepsin B on invasion and metastasis of gastric carcinoma. Chin Med J (Engl) 111(9): 784-788
53. Lopez, T., and Hanahan, D. 2002. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1(4): 339-353
54. Mai, J., Finley, R.L., Jr., Waisman, D.M., and Sloane, B.F. 2000. Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells. J Biol Chem 275(17): 12806-12812
55. Mai, J., Sameni, M., Mikkelsen, T., and Sloane, B.F. 2002. Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas. Biol Chem 383(9): 1407-1413
56. Mallen-St Clair, J., Shi, G.P., Sutherland, R.E., Chapman, H.A., Caughey, G.H., and Wolters, P.J. 2006. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol Chem 387(8): 1143-1146
57. Mason, R.W., Gal, S., and Gottesman, M.M. 1987. The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L. Biochem J 248(2): 449-454
58. Miyake, H., Hara, I., and Eto, H. 2004. Serum level of cathepsin B and its density in men with prostate cancer as novel markers of disease progression. Anticancer Res 24(4): 2573-2577
59. Mohamed, M.M., and Sloane, B.F. 2006. Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6(10): 764-775
60. Mort, J.S., Recklies, A.D., and Poole, A.R. 1985. Release of cathepsin B precursors from human and murine tumours. Prog Clin Biol Res 180: 243-245
61. Nagler, D.K., Kruger, S., Kellner, A., Ziomek, E., Menard, R., Buhtz, P., Krams, M., Roessner, A., and Kellner, U. 2004. Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia. Prostate 60(2): 109-119
62. Nasu, K., Kai, K., Fujisawa, K., Takai, N., Nishida, Y., and Miyakawa, I 2001. Expression of cathepsin L in normal endometrium and endometrial cancer. Eur J Obstet Gynecol Reprod Biol 99(1): 102-105
63. Nolan, D.J., Ciarrocchi, A., Mellick, A.S., Jaggi, J.S., Bambino, K., Gupta, S., Heikamp, E., McDevitt, M.R., Scheinberg, D.A., Benezra, R., and Mittal, V. 2007. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev 21(12): 1546-1558
64. Ondr, J.K., and Pham, C.T. 2004. Characterization of murine cathepsin W and its role in cellmediated cytotoxicity. J Biol Chem 279 (26): 27525-27533
65. Palermo, C., and Joyce, J.A. 2008. Cysteine cathepsin proteases as pharmacological targets in cancer. Trends Pharmacol Sci 29(1):22-28
66. Perl, A.K., Wilgenbus, P., Dahl, U., Semb, H., and Christofori, G. 1998. A causal role for Ecadherin in the transition from adenoma to carcinoma. Nature 392(6672): 190-193
67. Petermann, I., Mayer, C., Stypmann, J., Biniossek, M.L., Tobin, D.J., Engelen, M.A., Dandekar, T., Grune, T., Schild, L., Peters, C., and Reinheckel, T. 2006. Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. Faseb J 20(8): 1266-1268
68. Pham, C.T., and Ley, T.J. 1999. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci U S A 96(15): 8627-8632
69. Poole, A.R., Tiltman, K.J., Recklies, A.D., and Stoker, T.A. 1978. Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas. Nature 273(5663): 545-547
70. Rao, J.S. 2003. Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer 3(7): 489-501
71. Reinheckel, T., Hagemann, S., Dollwet-Mack, S., Martinez, E., Lohmuller, T., Zlatkovic, G., Tobin, D.J., Maas-Szabowski, N., and Peters, C. 2005. The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci 118(Pt 15): 3387-3395
72. Rempel, S.A., Rosenblum, M.L., Mikkelsen, T., Yan, P.S., Ellis, K.D., Golembieski, W.A., Sameni, M., Rozhin, J., Ziegler, G., and Sloane, B.F. 1994. Cathepsin B expression and localization in glioma progression and invasion. Cancer Res 54(23): 6027-6031
73. Roth, W., Deussing, J., Botchkarev, V.A., Pauly-Evers, M., Saftig, P., Hafner, A., Schmidt, P., Schmahl, W., Scherer, J., Anton-Lamprecht, I., Von Figura, K., Paus, R., and Peters, C. 2000. Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. Faseb J 14(13): 2075-2086
74. Saad, Z., Bramwell, V.H., Wilson, S.M., OMalley, F.P., Jeacock, J., and Chambers, A.F. 1998. Expression of genes that contribute to proliferative and metastatic ability in breast cancer resected during various menstrual phases. Lancet 351(9110): 1170-1173
75. Saftig, P., Hunziker, E., Wehmeyer, O., Jones, S., Boyde, A., Rommerskirch, W., Moritz, J.D., Schu, P., and von Figura, K. 1998. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A 95(23): 13453-13458
76. Sameni, M., Moin, K., and Sloane, B.F. 2000. Imaging proteolysis by living human breast cancer cells. Neoplasia 2(6): 496-504
77. Sameni, M., Dosescu, J., and Sloane, B.F. 2001. Imaging proteolysis by living human glioma cells. Biol Chem 382(5): 785-788
78. Santamaria, I., Velasco, G., Cazorla, M., Fueyo, A., Campo, E., and Lopez-Otin, C. 1998. Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. Cancer Res 58(8): 1624-1630
79. Schweiger, A., Staib, A., Werle, B., Krasovec, M., Lah, T.T., Ebert, W., Turk, V., and Kos, J. 2000. Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking. Br J Cancer 82(4): 782-788
80. Sevenich, L., Pennacchio, L.A., Peters, C., and Reinheckel, T. 2006. Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem 387(7): 885-891
81. Shi, G.P., Webb, A.C., Foster, K.E., Knoll, J.H., Lemere, C.A., Munger, J.S., and Chapman, H.A. 1994. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem 269(15): 11530-11536
82. Shi, G.P., Villadangos, J.A., Dranoff, G., Small, C., Gu, L., Haley, K.J., Riese, R., Ploegh, H.L., and Chapman, H.A. 1999. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity 10(2): 197-206
83. Shi, G.P., Sukhova, G.K., Kuzuya, M., Ye, Q., Du, J., Zhang, Y., Pan, J.H., Lu, M.L., Cheng, X. W., Iguchi, A., Perrey, S., Lee, A.M., Chapman, H.A., and Libby, P. 2003. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res 92(5): 493-500
84. Sinha, A.A., Gleason, D.F., Staley, N.A., Wilson, M.J., Sameni, M., and Sloane, B.F. 1995. Cathepsin B in angiogenesis of human prostate: an immunohistochemical and immunoelectron microscopic analysis. Anat Rec 241(3): 353-362
85. Sivaraman, J., Lalumiere, M., Menard, R., and Cygler, M. 1999. Crystal structure of wild-type human procathepsin K. Protein Sci 8(2): 283-290
86. Strojnik, T., Kos, J., Zidanik, B., Golouh, R., and Lah, T. 1999. Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors. Clin Cancer Res 5(3): 559-567
87. Stypmann, J., Glaser, K., Roth, W., Tobin, D.J., Petermann, I., Matthias, R., Monnig, G., Haverkamp, W., Breithardt, G., Schmahl, W., Peters, C., and Reinheckel, T. 2002. Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci USA 99(9): 6234-6239
88. Tang, C.H., Lee, J.W., Galvez, M.G., Robillard, L., Mole, S.E., and Chapman, H.A. 2006. Murine cathepsin f deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol 26(6): 2309-2316
89. Thomssen, C., Schmitt, M., Goretzki, L., Oppelt, P., Pache, L., Dettmar, P., Janicke, F., and Graeff, H. 1995. Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer. Clin Cancer Res 1(7): 741-746
90. Turk, B., Turk, D., and Turk, V. 2000. Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta 1477(1-2): 98-111
91. Turk, V., Turk, B., and Turk, D. 2001. Lysosomal cysteine proteases: facts and opportunities. Embo J 20(17): 4629-4633
92. Urbich, C., Heeschen, C., Aicher, A., Sasaki, K., Bruhl, T., Farhadi, M.R., Vajkoczy, P., Hofmann, W.K., Peters, C., Pennacchio, L.A., Abolmaali, N.D., Chavakis, E., Reinheckel, T., Zeiher, A. M., and Dimmeler, S. 2005. Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med 11(2): 206-213
93. Vasiljeva, O., Dolinar, M., Pungercar, J.R., Turk, V., and Turk, B. 2005. Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans. FEBS Lett 579(5): 1285-1290
94. Vasiljeva, O., Papazoglou, A., Kruger, A., Brodoefel, H., Korovin, M., Deussing, J., Augustin, N., Nielsen, B.S., Almholt, K., Bogyo, M., Peters, C., and Reinheckel, T. 2006. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res 66(10): 5242-5250
95. Wang, B., Sun, J., Kitamoto, S., Yang, M., Grubb, A., Chapman, H.A., Kalluri, R., and Shi, G.P. 2006. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem 281(9): 6020-6029
96. Watanabe, M., Higashi, T., Watanabe, A., Osawa, T., Sato, Y., Kimura, Y., Tominaga, S., Hashimoto, N., Yoshida, Y., Morimoto, S., and et al. 1989. Cathepsin B and L activities in gastric cancer tissue: correlation with histological findings. Biochem Med Metab Biol 42(1): 21-29
97. Werle, B., Lotterle, H., Schanzenbacher, U., Lah, T.T., Kalman, E., Kayser, K., Bulzebruck, H., Schirren, J., Krasovec, M., Kos, J., and Spiess, E. 1999. Immunochemical analysis of cathepsin B in lung tumours: an independent prognostic factor for squamous cell carcinoma patients. Br J Cancer 81(3): 510-519
98. Wiederanders, B., and Kirschke, H. 1989. The processing of a cathepsin L precursor in vitro. Arch Biochem Biophys 272(2): 516-521
99. Yasuda, Y., Li, Z., Greenbaum, D., Bogyo, M., Weber, E., and Bromme, D. 2004. Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J Biol Chem 279(35): 36761-36770
100. Zur Hausen, H 1987. Papillomaviruses in human cancer. Cancer 59 10 1692-1696