Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: Relation to prognosis and cigarette smoking

British Journal of Cancer

Volumn 82, Issue 4, 2000, Pages 782-788

  Schweiger, A ^a   Staib, A ^b   Werle, B ^b   Krasovec M ^c   Lah, T T ^d   Ebert, W ^b   Turk, V ^a   Kos, J ^a,c  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Department of Biochemical Research and Drug Design ^*  (Slovenia)

^d NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

Author keywords

Cathepsin H; Cigarette smoke; ELISA; Survival; Tumour markers

Indexed keywords

CATHEPSIN B; CATHEPSIN H; CATHEPSIN L; CYSTEINE PROTEINASE;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD LEVEL; CANCER SURVIVAL; CIGARETTE SMOKING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOLOGY; HUMAN; HUMAN TISSUE; LUNG CANCER; LUNG PARENCHYMA; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA;

CARCINOMA, NON-SMALL-CELL LUNG; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LUNG NEOPLASMS; PROGNOSIS; SMOKING; SURVIVAL ANALYSIS;

EID: 0033968099     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.1999.0999     Document Type: Article

References (46)

1. Abel U, Berger J and Wiebelt H (1984) An exploratory procedure for the evaluation of quantitative prognostic factors. Methods Inf Med 23: 154-156
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 72: 248-254
3. Budihna M, Strojan P, Šmid L, Škrk J, Vrhovec J, Župeve A, Rudolf Z, Žargi M, Krašovec M, Svetic B, Kopitar-Jerala N and Kos J (1996) Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma. Biol Chem Hoppe-Seyler 377: 385-390
4. Chang JC, Lesser M, Yoo OH and Orlowski M (1986) Increased cathepsin B-like activity in alveolar macrophages and bronchoalvcolar lavage fluid from smokers. Am Rev Respir Dis 134: 538-541
5. Chapman HA, Riese RJ and Shi G-P (1997) Emerging roles for cysteine proteases in human biology. Annu Rev Physiol 59: 63-88
6. Duffy MJ (1996) Proteases as prognostic markers in cancer. Clin Cancer Res 2: 613-618
7. Ebert W, Knoch H, Werle B, Trefz G, Muley TH and Spiess E (1994) Prognostic value of increased lung tumor tissue cathepsin B. Anticancer Res 14: 895-900
8. Ebert E, Werle B, Julke B, Kopitar-Jerala N, Kos J, Lah T, Abrahamson M, Spiess E and Ebert W (1997) Expression of cysteine protease inhibitors stefin A, stefin B, and cystatin C in human lung tumor tissue. Adv Exp Med Biol 421: 259-265
9. Gabrijelčič D, Svetic B., Spaič D, Škrk J, Budihna M, Dolenc I, Popovič T, Cotič V and Turk V (1992) Cathepsins B, H and L in human breast carcinoma. Eur J Clin Chem Clin Biochem 30: 69-74
10. Gairola CG, Galicki NI, Cardozo C, Lai YL and Besser M (1989) Cigarette smoke stimulates cathepsin B activity in alveolar macrophages of rats. J Lab Clin Med 114: 419-425
11. Hermenek P and Sobin L (1987) UICC TNM classification of malignant tumors, 4th edn. Springer Verlag: Berlin
12. Inoue T, Ishida T, Sugio K and Sugimachi K (1994) Cathepsin B expression and laminin degradation as factors influencing prognosis of surgically treated patients with lung adenocarcinoma. Cancer Res 54: 6133-6136
13. Ishii Y, Hashizume Y, Kominami E and Uchiyama Y (1991a) Changes in immunoreactivity for cathepsin H in rat type II alveolar epithelial cells and its proteolytic activity in bronchoalveolar lavage fluid over 24 hours. Anat Rec 230: 519-523
14. Ishii Y, Hashizume Y, Watanabe T, Waguri S, Sato N, Yamamoto M, Hasegawa S, Kominami E and Uchiyama Y (1991b) Cysteine proteinases in bronchoalveolar epithelial cells and lavage fluid of rat lung. J Histochem Cytochem 39: 461-468
15. Kaplan EL and Meier P (1958) Non-parametric estimation from incomplete observation. J Am Stat Assoc 53: 457-481
16. Kirschke H, Barrett AJ and Rawlings BJ (1995) Proteinases 1: Lysosomal cysteine proteinases. In: Protein Profile, Sheterline P (ed), pp. 1584-1620. Academic Press: London
17. Knoch H, Werle B, Ebert W and Spiess E (1994) Imbalance between cathepsin B and cysteine proteinase inhibitors is of prognostic significance in human lung cancer. Int J Oncol 5: 77-85
18. Koga H, Mori N, Yamada H, Nishimura Y, Tokuda K, Kato K and Imoto T (1992) Endo-and aminopeptidase activities of rat cathepsin H. Chem Pharm Bull 40: 965-970
19. Kos J and Lah TT (1998) Cysteine proteinases and their endogenous inhibitors: Target proteins for prognosis, diagnosis and therapy in cancer (review). Oncol Rep 5: 1349-1361
20. Kos J, Šmid A, Krašovec M, Svetic B, Lenarčič B, Vrhovec I, Škrk J and Turk V (1995) Lysosomal proteinases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancer. Biol Chem Hoppe-Seyler 376: 401-405
21. Kos J, Štabuc B, Schweiger A, Krašovec M, Cimerman N, Kopitar-Jerala N and Vrhovec I (1997) Cathepsins B, H, and L and their inhibitors stefin A and cystatin C in sera of melanoma patients. Clin Cancer Res 3: 1815-1822
22. Krepela E, Kasafirek E, Novak K and Viklicky J (1990) Increased cathepsin B activity in human lung tumors. Neoplasma 37: 61-70
23. Ledakis P, Tester WT, Rosenberg N, Romero-Fischmann D, Daskal I and Lah TT (1996) Cathepsins D, B, and L in malignant human lung tissue. Clin Cancer Res 2: 561-568
24. Lesser M, Galicki N, Cardozo C and Gairola CG (1989) Cathepsin L activity in alveolar macrophages of rats: Response to cigarette smoke. Am J Respir Cell Mol Biol 1: 371-376
25. Manegold C and Drings P (1998) Chemotherapie des nichtkleinzelligen Lungenkarzinoms. In: Thoraxtumoren: Diagnostik - Staging - gegenwärtiges Therapiekonzept, Drings P and Vogt-Moykpf I (eds), pp. 310-327. Springer Verlag: Heidelberg
26. McCaughan BC, Martini N and Bains MS (1985) Bronchial carcinoids: Review of 124 cases. J Thorac Cardiovasc Surg 89: 8-17
27. Mountain CF (1991) Surgical treatment of lung cancer. Critic Rev Oncol/Hematol 11: 179-207
28. Ohwada A, Takahshi H, Nagaoka I, Iwabuchi K, Mikami K and Kira S (1995) Effect of cigarette smoke on the mRNA and protein expression of carcinoembryonic antigen (CEA), a possible chemoattractant for neutrophils in human bronchioloalveolar tissues. Thorax 50: 651-657
29. Qian F, Chan SJ, Gong Q, Bajkowski AS, Steiner DF and Frankfater A (1991) The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors. Biomed Biochim Acta 50: 531-540
30. San Segundo B, Chan SJ and Steiner DF (1986) Differences in cathepsin B mRNA levels in rat tissues suggest specialized functions. FEBS Lett 201: 251-256
31. Schiller JH (1998) Lung cancer: Therapeutic modalities and cytoprotection. Lung 176: 145-164
32. Schmitt M, Jänicke F and Graeff H (1992) Tumor-associated proteases. Fibrinolysis 6: 3-26
33. Schraube P, Kimmig B, Latz D, Flentje M and Wannenmacher M (1998) Radiotherapie des Bronchialkarzinoms. In: Thoraxtumoren: Diagnostik - Staging - gegenwärtiges Therapiekonzept. Drings P and Vogt-Moykopf 1 (eds), pp. 277-295. Springer Verlag: Heidelberg
34. Schweiger A, Štabuc B, Popovič T, Turk V and Kos J (1997) Enzyme-linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera. J Immunol Methods 201: 165-172
35. Sivaparvathi M, Sawaya R, Gokaslan ZL, Chintala KS and Rao JS (1996) Expression and the role of cathepsin H in human glioma progression and invasion. Cancer Lett 104: 121-126
36. Sloane BF, Moin K and Lah TT (1994) Regulation of lysosomal endopeptidases in malignant neoplasia. In: Biochemical and Molecular Aspects of Selected Cancers, Pretlow TG and Pretlow TP (eds), pp. 411-472. Academic Press: New York
37. Sukoh N, Shosaku A, Ogura S, Isohe H, Takekawa H, Inoue K and Kawakami Y (1994) Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer. Cancer 74: 46-51
38. Takahashi H, Ishidoh K, Muno D, Ohwada A, Nukiwa T, Kominami E and Kira S (1993) Cathepsin L activity is increased in alveolar macrophages and bronchoalveolar lavage fluid of smokers. Am Rev Respir Dis 147: 1562-1568
39. Treftz G, Lüthgens K, Erdel M, Spiess E and Ebert W (1989) Plasminogen activator and cathepsin B in normal and malignant human lung tissue. J Cancer Res Clin Oncol 115: S50
40. Uchiyama Y, Waguri S, Sato N, Watanabe T, Ishido K and Kominami E (1994) Review: Cell and tissue distribution of lysosomal cysteine proteinases, cathepsins B, H and L, and their biological roles. Acta Histochem Cytochem 27: 287-308
41. Werle B, Ebert W, Klein W and Spiess E (1995) Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue. Biol Chem Hoppe-Seyler 376: 157-164
42. Werle B, Jülke B, Lah T, Kos J, Spiess E and Ebert W (1997a) Cathepsin B and Cathepsin L: Prognostic factors in human lung cancer? In: Proteolysis in Cell Function, Hopsu-Havu VK, Jarvinen M and Kirschke H (eds), pp. 472-478. IOS Press: Amsterdam
43. Werle B, Jülke B, Lah T, Spiess E and Ebert W (1997b) Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung. Br J Cancer 75: 1137-1143
44. Werle B, Lötterle H, Schanzenbächer U, Lah TT, Kalman E, Kayser K, Bülzebruck H, Schirren S, Krasovec M, Kos J and Spiess E (1999a) Immunochemical analysis of cathepsin B in lung tumours: An independent prognostic factor for squamous cell carcinoma patients. Br J Cancer 81: 510-519
45. Werle B, Staib A, Jülke B, Ebert W, Zladoidsky P, Sekirnik A, Kos J and Spiess E (1999b) Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extracts. Biol Chem 380: 1109-1116
46. WHO (1981) Histological Classification of Lung Tumours. World Health Organization: Geneva