Chronic systemic hypoxia promotes LNCaP prostate cancer growth in vivo

Prostate

Volumn 70, Issue 11, 2010, Pages 1243-1254

  Terraneo, Laura ^a   Bianciardi, Paola ^a   Caretti, Anna ^a   Ronchi, Raffaella ^a   Samaja, Michele ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Chronic hypoxia; Hypoxia inducible factor 1 ; Reoxygenation

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PROTEIN KINASE B; VASCULOTROPIN; HEMOGLOBIN; OXYGEN; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOFLUORESCENCE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; ANIMAL; BODY WEIGHT; CELL HYPOXIA; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROSTATE TUMOR; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; CELL HYPOXIA; CELL LINE, TUMOR; HEMOGLOBINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, NUDE; OXYGEN; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77955944752     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21160     Document Type: Article

References (46)

1. Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004;14(3):198-206. (Pubitemid 38903223)
2. Endrich B, Reinhold HS, Gross JF, Intaglietta M. Tissue perfusion inhomogeneity during early tumor growth in rats. J Natl Cancer Inst 1979;62(2):387-395.
3. Hockel M, Vaupel P. Biological consequences of tumor hypoxia. Semin Oncol 2001;28:36-41.
4. Brown JM, Giaccia AJ. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy. Cancer Res 1998;58(7):1408- 1416.
5. Li XF, O'Donoghue JA. Hypoxia in microscopic tumors. Cancer Lett 2008;264(2):172-180.
6. Mayer A, Wree A, Hockel M, Leo C, Pilch H, Vaupel P. Lack of correlation between expression of HIF-1alpha protein and oxygenation status in identical tissue areas of squamous cell carcinomas of the uterine cervix. Cancer Res 2004;64(16):5876-5881.
7. Jiang H, Feng Y. Hypoxia-inducible factor 1alpha (HIF-1alpha) correlated with tumor growth and apoptosis in ovarian cancer. Int J Gynecol Cancer 2006;16(Suppl. 1):405-412.
8. Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 2008;15(4):678-685.
9. Caretti A, Morel S, Milano G, Fantacci M, Bianciardi P, Ronchi R, Vassalli G, von Segesser LK, Samaja M. Heart HIF-1alpha and MAP kinases during hypoxia: Are they associated in vivo? Exp Biol Med (Maywood) 2007;232(7):887-894.
10. Ripamonti M, Vigano A, Moriggi M, Milano G, von Segesser LK, Samaja M, Gelfi C. Cytochrome c oxidase expression in chronic and intermittent hypoxia rat gastrocnemius muscle quantitated by CE. Electrophoresis 2006;27(19):3897-3903. (Pubitemid 44608409)
11. Milano G, Bianciardi P, Corno AF, Raddatz E, Morel S, von Segesser LK, Samaja M. Myocardial impairment in chronic hypoxia is abolished by short aeration episodes: Involvement of K+ATP channels. Exp Biol Med (Maywood) 2004;229(11):1196-1205.
12. Tarricone E, Scapin C, Vitadello M, Esposito F, Margonato V, Milano G, Samaja M, Gorza L. Cellular distribution of Hsp70 expression in rat skeletal muscles. Effects of moderate exercise training and chronic hypoxia. Cell Stress Chaperones 2008;13(4):483-495.
13. Morel S, Milano G, Ludunge KM, Corno AF, Samaja M, Fleury S, Bonny C, Kappenberger L, von Segesser LK, Vassalli G. Brief reoxygenation episodes during chronic hypoxia enhance post-hypoxic recovery of LV function: Role of mitogen-activated protein kinase signaling pathways. Basic Res Cardiol 2006;101(4):336-345.
14. Milano G, Corno AF, Lippa S, Von Segesser LK, Samaja M. Chronic and intermittent hypoxia induce different degrees of myocardial tolerance to hypoxia-induced dysfunction. Exp Biol Med (Maywood) 2002;227(6):389-397.
15. Zhong H, De Marzo A, Laughner E, Lim M, Hilson D, Zagzag D. Overexpression of hypoxia inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999;59:5830-5835.
16. Ghafar MA, Anastasiadis AG, Chen MW, Burchardt M, Olsson LE, Xie H, Benson MC, Buttyan R. Acute hypoxia increases the aggressive characteristics and survival properties of prostate cancer cells. Prostate 2003;54(1):58-67.
17. Zhong H, Semenza GL, Simons JW, De Marzo AM. Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detect Prev 2004;28(2):88-93. (Pubitemid 38448745)
18. Kimbro KS, Simons JW. Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer 2006;13(3):739-749.
19. Park SY, Kim YJ, Gao AC, Mohler JL, Onate SA, Hidalgo AA, Ip C, Park EM, Yoon SY, Park YM. Hypoxia increases androgen receptor activity in prostate cancer cells. Cancer Res 2006;66(10):5121-5129.
20. Fantacci M, Bianciardi P, Caretti A, Coleman TR, Cerami A, Brines M, Samaja M. Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia. Proc Natl Acad Sci USA 2006;103(46):17531- 17536.
21. Bianciardi P, Fantacci M, Caretti A, Ronchi R, Milano G, Morel S, von Segesser L, Corno A, Samaja M. Chronic in vivo hypoxia in various organs: Hypoxia-inducible factor-1alpha and apoptosis. Biochem Biophys Res Commun 2006;342(3):875-880. (Pubitemid 43320479)
22. Corno AF, Milano G, Samaja M, Tozzi P, von Segesser LK. Chronic hypoxia: A model for cyanotic congenital heart defects. J Thorac Cardiovasc Surg 2002;124(1):105-112.
23. Stroka D, Burkhardt T, Desbaillets I, Wenger R, Neil D, Bauer C, Gassmann M, Candinas D. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J 2001;15:2445-2453.
24. Chandel N, McClintock D, Feliciano C, Wood T, Melendez J, Rodriguez A, Schumacker P. Reactive oxygen species generated at mitochondria complex III stabilize HIF-1-alpha during hypoxia: A mechanism of oxygen sensing. J Biol Chem 2000;275:25130-25138.
25. Semenza GL, Prabhakar NR. HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia. Antioxid Redox Signal 2007;9(9):1391-1396.
26. Toffoli S, Michiels C. Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours. FEBS J 2008;275(12):2991-3002. (Pubitemid 351743577)
27. Moeller BJ, Cao Y, Li CY, Dewhirst MW. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004;5(5):429-441.
28. Martinive P, Defresne F, Bouzin C, Saliez J, Lair F, Gregoire V, Michiels C, Dessy C, Feron O. Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: Implications for anticancer therapies. Cancer Res 2006;66(24):11736-11744.
29. Mizukami Y, Kohgo Y, Chung DC. Hypoxia inducible factor-1 independent pathways in tumor angiogenesis. Clin Cancer Res 2007;13(19):5670-5674.
30. Coffey RN, Morrissey C, Taylor CT, Fitzpatrick JM, Watson RW. Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells. Cancer 2005;103(7):1363- 1374. (Pubitemid 40410730)
31. Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol 2005;25(12):4853-4862.
32. Guzy RD, Mack MM, Schumacker PT. Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast. Antioxid Redox Signal 2007;9(9):1317-1328.
33. Jiao JD, Garg V, Yang B, Hu K. Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning. Cardiovasc Res 2008;77(1):126-133.
34. Walsh S, Gill C, O'Neill A, Fitzpatrick JM, Watson RW. Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation. Int J Cancer 2009;124(8):1871-1878.
35. Thomas R, Kim MH. A HIF-1alpha-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells. Prostate 2009;69(3):263-275.
36. Thakkar H, Chen X, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N, Srivastava RK. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance. J Biol Chem 2001;276(42):38361-38369.
37. Mabjeesh NJ, Willard MT, Frederickson CE, Zhong H, Simons JW. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res 2003;9(7):2416-2425. (Pubitemid 36842080)
38. Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 2001;12(7):363-369.
39. Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60(6):1541-1545.
40. Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 2004;10(6):594-601.
41. Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002;64(5-6):993-998.
42. Bardos JI, Ashcroft M. Hypoxia-inducible factor-1 and oncogenic signalling. Bioessays 2004;26(3):262-269.
43. Martinive P, Defresne F, Quaghebeur E, Daneau G, Crokart N, Gregoire V, Gallez B, Dessy C, Feron O. Impact of cyclic hypoxia on HIF-1alpha regulation in endothelial cells - New insights for anti-tumor treatments. FEBS J 2009;276(2):509-518.
44. Toffoli S, Feron O, Raes M, Michiels C. Intermittent hypoxia changes HIF-1alpha phosphorylation pattern in endothelial cells: Unravelling of a new PKA-dependent regulation of HIF-1alpha. Biochim Biophys Acta 2007;1773(10):1558-1571. (Pubitemid 47498610)
45. Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M. The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. J Biol Chem 2009;284(8):5332-5342.
46. Mazure NM, Chen EY, Laderoute KR, Giaccia AJ. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 1997;90(9):3322-3331.