Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 7, 2010, Pages 3347-3353

  Yu Wai Man, Patrick ^a,b   Lai Cheong, Joey ^c   Borthwick, Gillian M ^a   He, Langping ^a   Taylor, Geoffrey A ^a   Greaves, Laura C ^a   Taylor, Robert W ^a   Griffiths, Philip G ^a,b   Turnbull, Douglass M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b ROYAL VICTORIA INFIRMARY   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; SUCCINATE DEHYDROGENASE;

ADULT; ADULTHOOD; AGED; AGING; ARTICLE; CELL LYSATE; CHILD; CYTOCHROME C OXIDASE DEFICIENCY; DNA DAMAGE; EXTRAOCULAR MUSCLE; FEMALE; GENE DELETION; GENE SEQUENCE; HISTOCHEMISTRY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; POINT MUTATION; PRESCHOOL CHILD; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SOMATIC CELL; TISSUE SECTION; ADOLESCENT; CHROMOSOME DELETION; ENZYMOLOGY; GENETICS; METABOLISM; MIDDLE AGED; MUSCLE MITOCHONDRION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CHILD; CHILD, PRESCHOOL; CHROMOSOME DELETION; CYTOCHROME-C OXIDASE DEFICIENCY; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; FEMALE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA, MUSCLE; OCULOMOTOR MUSCLES; POINT MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUCCINATE DEHYDROGENASE;

EID: 77955863883     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4660     Document Type: Article

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