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Volumn 47, Issue 8, 2009, Pages 1147-1153

α-Lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine

Author keywords

Cysteine; Free radicals; Homocysteine; Methionine; Transmethylation; Transsulfuration

Indexed keywords

2 AMINOBUTYRIC ACID; 2 MERCAPTOETHANE SULFONIC ACID; CYSTATHIONINE; CYSTEINE; DIMETHYLGLYCINE; GLUTATHIONE; HOMOCYSTEINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SULFONIC ACID DERIVATIVE; THIOCTIC ACID; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

EID: 70249137923     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.07.019     Document Type: Article
Times cited : (16)

References (43)
  • 3
    • 1042290476 scopus 로고    scopus 로고
    • (R)-α-Lipoic acid reverses the age-related loss in GSH redox status in postmitotic tissues: evidence for increased cysteine requirement for GSH synthesis
    • Suh J.H., Wang H., Liu R.M., Liu J., and Hagen TM. (R)-α-Lipoic acid reverses the age-related loss in GSH redox status in postmitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch. Biochem. Biophys. 423 (2004) 126-135
    • (2004) Arch. Biochem. Biophys. , vol.423 , pp. 126-135
    • Suh, J.H.1    Wang, H.2    Liu, R.M.3    Liu, J.4    Hagen, TM.5
  • 5
    • 26444492517 scopus 로고    scopus 로고
    • Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds
    • Lateef H., Aslam M.N., Stevens M.J., and Varani J. Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds. Arch. Dermatol. Res. 297 (2005) 75-83
    • (2005) Arch. Dermatol. Res. , vol.297 , pp. 75-83
    • Lateef, H.1    Aslam, M.N.2    Stevens, M.J.3    Varani, J.4
  • 6
    • 46649091905 scopus 로고    scopus 로고
    • Antioxidant effects of methionine, alpha-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats
    • Caylak E., Aytekin M., and Halifeoglu I. Antioxidant effects of methionine, alpha-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats. Exp. Toxicol. Pathol. 60 (2008) 289-294
    • (2008) Exp. Toxicol. Pathol. , vol.60 , pp. 289-294
    • Caylak, E.1    Aytekin, M.2    Halifeoglu, I.3
  • 7
    • 35948957816 scopus 로고    scopus 로고
    • Acetyl-l-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests
    • Milgram N.W., Araujo J.A., Hagen T.M., Treadwell B.V., and Ames B.N. Acetyl-l-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. FASEB J. 21 (2007) 3756-3762
    • (2007) FASEB J. , vol.21 , pp. 3756-3762
    • Milgram, N.W.1    Araujo, J.A.2    Hagen, T.M.3    Treadwell, B.V.4    Ames, B.N.5
  • 8
    • 0242661909 scopus 로고    scopus 로고
    • Alpha-lipoic acid and cardiovascular disease
    • Wollin S.D., and Jones P.J. Alpha-lipoic acid and cardiovascular disease. J. Nutr. 133 (2003) 3327-3330
    • (2003) J. Nutr. , vol.133 , pp. 3327-3330
    • Wollin, S.D.1    Jones, P.J.2
  • 9
    • 33749363594 scopus 로고    scopus 로고
    • Alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet
    • Yi X., and Maeda N. Alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes 55 (2006) 2238-2244
    • (2006) Diabetes , vol.55 , pp. 2238-2244
    • Yi, X.1    Maeda, N.2
  • 10
    • 34248525050 scopus 로고    scopus 로고
    • Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated α-lipoyl derivative
    • Brown S.E., Ross M.F., Sanjuan-Pla A., Manas A.R., Smith R.A., and Murphy M.P. Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated α-lipoyl derivative. Free Radic. Biol. Med. 42 (2007) 1766-1780
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 1766-1780
    • Brown, S.E.1    Ross, M.F.2    Sanjuan-Pla, A.3    Manas, A.R.4    Smith, R.A.5    Murphy, M.P.6
  • 12
    • 0142135387 scopus 로고    scopus 로고
    • Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers
    • Teichert J., Hermann R., Ruus P., and Preiss R. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. J. Clin. Pharmacol. 43 (2003) 1257-1267
    • (2003) J. Clin. Pharmacol. , vol.43 , pp. 1257-1267
    • Teichert, J.1    Hermann, R.2    Ruus, P.3    Preiss, R.4
  • 13
    • 20344363148 scopus 로고    scopus 로고
    • Elimination of high amounts of extracellular homocysteine in human cell lines
    • Hultberg B. Elimination of high amounts of extracellular homocysteine in human cell lines. Clin. Chim. Acta 356 (2005) 117-124
    • (2005) Clin. Chim. Acta , vol.356 , pp. 117-124
    • Hultberg, B.1
  • 14
    • 0033818441 scopus 로고    scopus 로고
    • Pathways and regulation of homocysteine metabolism in mammals
    • Finkelstein J.D. Pathways and regulation of homocysteine metabolism in mammals. Semin. Thromb. Hemostasis 26 (2000) 219-225
    • (2000) Semin. Thromb. Hemostasis , vol.26 , pp. 219-225
    • Finkelstein, J.D.1
  • 15
    • 0345865493 scopus 로고    scopus 로고
    • Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells
    • Panayiotidis M.I., Stabler S.P., Allen R.H., Ahmad A., and White C.W. Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells. Chem. Biol. Interact. 147 (2004) 87-97
    • (2004) Chem. Biol. Interact. , vol.147 , pp. 87-97
    • Panayiotidis, M.I.1    Stabler, S.P.2    Allen, R.H.3    Ahmad, A.4    White, C.W.5
  • 17
    • 0027982946 scopus 로고
    • Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver
    • Yeo E.J., and Wagner C. Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver. Proc. Natl. Acad. Sci. USA 91 (1994) 210-214
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 210-214
    • Yeo, E.J.1    Wagner, C.2
  • 19
    • 34447631659 scopus 로고    scopus 로고
    • MESNA as a nonvitamin intervention to lower plasma total homocysteine concentration: implications for assessment of the homocysteine theory of atherosclerosis
    • Urquhart B.L., Freeman D.J., Spence J.D., and House A.A. MESNA as a nonvitamin intervention to lower plasma total homocysteine concentration: implications for assessment of the homocysteine theory of atherosclerosis. J. Clin. Pharmacol. 47 (2007) 991-997
    • (2007) J. Clin. Pharmacol. , vol.47 , pp. 991-997
    • Urquhart, B.L.1    Freeman, D.J.2    Spence, J.D.3    House, A.A.4
  • 20
    • 0031707995 scopus 로고    scopus 로고
    • Chromatographic analysis of lipoic acid and related compounds
    • Kataoka H. Chromatographic analysis of lipoic acid and related compounds. J. Chromatogr. B Biomed. Sci. Appl. 717 (1998) 247-262
    • (1998) J. Chromatogr. B Biomed. Sci. Appl. , vol.717 , pp. 247-262
    • Kataoka, H.1
  • 21
    • 0023870112 scopus 로고
    • Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry
    • Stabler S.P., Marcell P.D., Podell E.R., Allen R.H., Savage D.G., and Lindenbaum J. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J. Clin. Invest. 81 (1988) 466-474
    • (1988) J. Clin. Invest. , vol.81 , pp. 466-474
    • Stabler, S.P.1    Marcell, P.D.2    Podell, E.R.3    Allen, R.H.4    Savage, D.G.5    Lindenbaum, J.6
  • 22
    • 0027160548 scopus 로고
    • Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency
    • Stabler S.P., Lindenbaum J., Savage D.G., and Allen R.H. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood 81 (1993) 3404-3413
    • (1993) Blood , vol.81 , pp. 3404-3413
    • Stabler, S.P.1    Lindenbaum, J.2    Savage, D.G.3    Allen, R.H.4
  • 23
    • 0027515431 scopus 로고
    • Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism
    • Allen R.H., Stabler S.P., and Lindenbaum J. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism 42 (1993) 1448-1460
    • (1993) Metabolism , vol.42 , pp. 1448-1460
    • Allen, R.H.1    Stabler, S.P.2    Lindenbaum, J.3
  • 24
    • 0742269630 scopus 로고    scopus 로고
    • Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry
    • Stabler S.P., and Allen R.H. Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry. Clin. Chem. 50 (2004) 365-372
    • (2004) Clin. Chem. , vol.50 , pp. 365-372
    • Stabler, S.P.1    Allen, R.H.2
  • 25
    • 33646193692 scopus 로고    scopus 로고
    • Rapid determination of reduced and oxidized glutathione levels using a new thiol-masking reagent and the enzymatic recycling method: application to the rat liver and bile samples
    • Shaik I.H., and Mehvar R. Rapid determination of reduced and oxidized glutathione levels using a new thiol-masking reagent and the enzymatic recycling method: application to the rat liver and bile samples. Anal. Bioanal. Chem. 385 (2006) 105-113
    • (2006) Anal. Bioanal. Chem. , vol.385 , pp. 105-113
    • Shaik, I.H.1    Mehvar, R.2
  • 27
    • 13844294309 scopus 로고    scopus 로고
    • Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia
    • Doshi S., McDowell I., Goodfellow J., Stabler S., Boger R., Allen R., Newcombe R., Lewis M., and Moat S. Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia. Metabolism 54 (2005) 351-360
    • (2005) Metabolism , vol.54 , pp. 351-360
    • Doshi, S.1    McDowell, I.2    Goodfellow, J.3    Stabler, S.4    Boger, R.5    Allen, R.6    Newcombe, R.7    Lewis, M.8    Moat, S.9
  • 30
    • 37149038891 scopus 로고    scopus 로고
    • The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage
    • Abdel-Zaher A.O., Abdel-Hady R.H., Mahmoud M.M., and Farrag M.M. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology 243 (2008) 261-270
    • (2008) Toxicology , vol.243 , pp. 261-270
    • Abdel-Zaher, A.O.1    Abdel-Hady, R.H.2    Mahmoud, M.M.3    Farrag, M.M.4
  • 32
    • 0037076855 scopus 로고    scopus 로고
    • Lipoic acid increases glutathione production and enhances the effect of mercury in human cell lines
    • Hultberg B., Andersson A., and Isaksson A. Lipoic acid increases glutathione production and enhances the effect of mercury in human cell lines. Toxicology 175 (2002) 103-110
    • (2002) Toxicology , vol.175 , pp. 103-110
    • Hultberg, B.1    Andersson, A.2    Isaksson, A.3
  • 33
    • 41049113671 scopus 로고    scopus 로고
    • Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity
    • Jia Z., Hallur S., Zhu H., Li Y., and Misra H.P. Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity. Neurochem. Res. 33 (2008) 790-800
    • (2008) Neurochem. Res. , vol.33 , pp. 790-800
    • Jia, Z.1    Hallur, S.2    Zhu, H.3    Li, Y.4    Misra, H.P.5
  • 35
    • 21744450131 scopus 로고    scopus 로고
    • Effect of drugs on homocysteine concentrations
    • Dierkes J., and Westphal S. Effect of drugs on homocysteine concentrations. Semin. Vasc. Med. 5 (2005) 124-139
    • (2005) Semin. Vasc. Med. , vol.5 , pp. 124-139
    • Dierkes, J.1    Westphal, S.2
  • 37
    • 33745050402 scopus 로고    scopus 로고
    • Tolcapone decreases plasma levels of S-adenosyl-l-homocysteine and homocysteine in treated Parkinson's disease patients
    • Müller T., and Kuhn W. Tolcapone decreases plasma levels of S-adenosyl-l-homocysteine and homocysteine in treated Parkinson's disease patients. Eur. J. Clin. Pharmacol. 62 (2006) 447-450
    • (2006) Eur. J. Clin. Pharmacol. , vol.62 , pp. 447-450
    • Müller, T.1    Kuhn, W.2
  • 38
    • 37549020089 scopus 로고    scopus 로고
    • The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects
    • Carlson D.A., Smith A.R., Fischer S.J., Young K.L., and Packer L. The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects. Altern. Med. Rev. 12 (2007) 343-351
    • (2007) Altern. Med. Rev. , vol.12 , pp. 343-351
    • Carlson, D.A.1    Smith, A.R.2    Fischer, S.J.3    Young, K.L.4    Packer, L.5
  • 40
    • 33845726964 scopus 로고    scopus 로고
    • Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
    • Simbula G., Columbano A., Ledda-Columbano G.M., Sanna L., Deidda M., Diana A., and Pibiri M. Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells. Apoptosis 12 (2007) 113-123
    • (2007) Apoptosis , vol.12 , pp. 113-123
    • Simbula, G.1    Columbano, A.2    Ledda-Columbano, G.M.3    Sanna, L.4    Deidda, M.5    Diana, A.6    Pibiri, M.7
  • 41
    • 43549122067 scopus 로고    scopus 로고
    • Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway
    • Shi D.Y., Liu H.L., Stern J.S., Yu P.Z., and Liu S.L. Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS Lett. 582 (2008) 1667-1671
    • (2008) FEBS Lett. , vol.582 , pp. 1667-1671
    • Shi, D.Y.1    Liu, H.L.2    Stern, J.S.3    Yu, P.Z.4    Liu, S.L.5
  • 42
    • 64549160944 scopus 로고    scopus 로고
    • Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy
    • Selvakumar E., and Hsieh T.C. Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy. J. Hematol. Oncol. 1 (2008) 4
    • (2008) J. Hematol. Oncol. , vol.1 , pp. 4
    • Selvakumar, E.1    Hsieh, T.C.2


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