Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of γ-cystathionase?

Scandinavian Journal of Gastroenterology

Volumn 35, Issue 8, 2000, Pages 866-872

  Look, M P ^a   Riezler, R ^a   Reichel, C ^a   Brensing, K A ^a   Rockstroh, J K ^a   Stabler, S P ^a   Spengler, U ^a   Berthold, H K ^a   Sauerbruch, T ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Cystathionine; Folate; Liver cirrhosis; Methionine metabolism; N,N dimethylglycine; Vitamin B12; Vitamin B6

Indexed keywords

CYANOCOBALAMIN; CYSTATHIONINE; CYSTATHIONINE GAMMA LYASE; DIMETHYLGLYCINE; FOLIC ACID; HOMOCYSTEINE; METHIONINE; PYRIDOXINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CHRONIC LIVER DISEASE; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; ENZYME ACTIVITY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; LIVER CIRRHOSIS; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL;

EID: 0033821506     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655200750023255     Document Type: Article

References (30)

1. Evidence for impairment of transsulfuration pathway in cirrhosis
2. Defective methionine metabolism in cirrhosis: Relation to severity of liver disease
3. Sulfur amino acid metabolism in hepatobiliary disorders
4. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease
5. Glutathione
6. Rat liver glutathione: A possible role as a reservoir of cysteine
7. Alcohol and the liver: 1994 update
8. Glutathione deficiency in alcoholics: Risk factor for paracetamol hepatotoxicity
9. Antioxidant defenses in metal-induced liver damage
10. Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis
11. Inactivation and dissociation of S-adenosylmethionine synthetase by modification of sulfhydryl groups and its possible occurrence in cirrhosis
12. Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction
13. The pathogenesis of hyperhomocysteinemia: Interruption of coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine
14. Vitamin B6 repletion in cirrhotics with oral pyridoxine: Failure to improve amino acid metabolism
15. Plasma cysteine, cystine, and glutathione in cirrhosis
16. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism
17. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency
18. Elevation of 2-methylcitric I and II levels in serum, urine and cerebrospinal fluid of patients with coalbumin deficiency
19. Value of prealbumin plasma levels as liver test
20. Transsection of the oesophagus for bleeding oesophageal varices
21. Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis
22. Hyperhomocysteinemia in chronic alcoholism: Correlation with folate, vitamin B12, and vitamin B6 status
23. The effect of a subnormal vitamin B-6 status on homocysteine metabolism
24. Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations
25. Content of sulfur amino acids and vitamin B6 and related enzyme activities in rats with chronic renal failure fed a high methionine diet
26. Evidence of altered homocysteine metabolism in chronic renal failure
27. Effect of S-adenosyl-L-methionine administration on red blood cell cysteine and glutathione levels in alcoholic patients with and without liver disease
28. Decreased production of glutathione in patients with cirrhosis
29. S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis
30. S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multi-center clinical trial