Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA

British Journal of Pharmacology

Volumn 161, Issue 1, 2010, Pages 51-64

  Tumati, S ^a   Roeske, W R ^a,b   Largent Milnes, T ^a   Wang, R ^a   Vanderah, T W ^a   Varga, E V ^a,b,c  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

allodynia; analgesic tolerance; CGRP; hyperalgesia; opioid; Raf 1

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; MORPHINE; RAF PROTEIN; SMALL INTERFERING RNA; SODIUM CHLORIDE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; INJECTION; MALE; NOCICEPTION; NONHUMAN; OSMOTIC MINIPUMP; PAIN; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPINAL CORD; TREATMENT DURATION; UPREGULATION;

ANIMALS; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MAP KINASE KINASE KINASES; MORPHINE; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SPINAL CORD;

EID: 77955833346     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00869.x     Document Type: Article

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