Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia

European Journal of Pharmacology

Volumn 601, Issue 1-3, 2008, Pages 207-208

  Tumati, Suneeta ^a   Milnes, Tally Largent ^a   Yamamura, Henry I ^a,b,c   Vanderah, Todd W ^a   Roeske, William R ^a,c   Varga, Eva V ^a,b,c  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Hyperalgesia; Morphine; Opioids; Raf 1

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; MORPHINE; RAF 1 SELECTIVE SMALL INTERFERING RNA CONJUGATE; RAF PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; ENCAPSULATION; HYPERALGESIA; INHIBITION KINETICS; LATENT PERIOD; LONG TERM CARE; LUMBAR SPINAL CORD; MALE; NERVE CELL CULTURE; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; OSMOTIC MINIPUMP; PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL GANGLION; THERMAL INJURY; THERMAL STIMULATION; TREATMENT DURATION; WESTERN BLOTTING;

ANALGESICS, OPIOID; ANIMALS; DRUG ADMINISTRATION SCHEDULE; HOT TEMPERATURE; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MORPHINE; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SPINAL CORD;

EID: 56949086803     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.10.033     Document Type: Article

References (4)

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4. Yue X., Tumati S., Navratilova E., Stropova D., St John P.A., Roeske W.R., Vanderah T.W., Yamamura H.I., and Varga E.V. Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner. Eur. J. Pharmacol. 584 (2008) 272-277