Mass transfer and nutrient absorption in a simulated model of small intestine

Journal of Food Science

Volumn 75, Issue 6, 2010, Pages

  Tharakan, A ^a   Norton, I T ^a   Fryer, P J ^a   Bakalis, S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Digestion; In vitro model; Nutrient

Indexed keywords

DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; GALACTAN; GLUCOSE; GUAR GUM; MANNAN; PLANT GUM; RIBOFLAVIN; STARCH;

ARTICLE; AUDIOVISUAL EQUIPMENT; BIOLOGICAL MODEL; CHEMISTRY; ELEMENTAL DIET; FOOD HANDLING; GASTROINTESTINAL MOTILITY; HUMAN; INSTRUMENTATION; INTESTINE ABSORPTION; METABOLISM; OSMOLARITY; PHYSIOLOGY; SMALL INTESTINE; STOMACH JUICE; VISCOSITY;

FOOD TECHNOLOGY; FOOD, FORMULATED; GALACTANS; GASTROINTESTINAL CONTENTS; GASTROINTESTINAL MOTILITY; GLUCOSE; HUMANS; INDICATORS AND REAGENTS; INTESTINAL ABSORPTION; INTESTINE, SMALL; MANNANS; MODELS, ANATOMIC; MODELS, BIOLOGICAL; OSMOLAR CONCENTRATION; PLANT GUMS; RIBOFLAVIN; STARCH; VISCOSITY;

CYAMOPSIS TETRAGONOLOBA;

EID: 77955811501     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2010.01659.x     Document Type: Article

References (50)

1. Bird RB, Stewart WE, Lightfoot EN. Transport phenomena 2007, 2nd ed, John Wiley & Sons Inc
2. Blackburn NA, Johnson IT. The effect of guar gum on the viscosity of the gastrointestinal contents and on glucose-uptake from the perfused jejunum in the rat. Br J Nutr 1981, 46(2):239-46.
3. Blackburn NA, Holgate AM, Read NW. Does guar gum improve post-prandial hyperglycemia in humans by reducing small intestinal contact area. Br J Nutr 1984a, 52(2):197-204.
4. Blackburn NA, Redfern JS, Jarjis H, Holgate AM, Hanning I, Scarpello JHB, Johnson IT, Read NW. The mechanism of action of guar gum in improving glucose-tolerance in man. Clin Sci 1984b, 66(3):329-36.
5. Blanquet S, Marol-Bonnin S, Beyssac E, Pompon D, Renaud M, Alric M. The " biodrug" concept: an innovative approach to therapy. Trends Biotechnol 2001, 19(10):393-400.
6. Chen J. Food oral processing: a review. Food Hydrocolloids 2009, 23(1):1-25.
7. Chu B-S, Rich GT, Ridout MJ, Faulks RM, Wickham MSJ, Wilde PJ. Modulating pancreatic lipase activity with galactolipids: effects of emulsion interfacial composition. Langmuir 2009, 25(16):9352-60.
8. Edwards CA, Blackburn NA, Craigen L, Davison P, Tomlin J, Sugden K, Johnson IT, Read NW. Viscosity of food gums determined in vitro related to their hypoglycemic actions. Am J Clin Nutr 1987, 46(1):72-7.
9. Ekmekcioglu C. Intestinal bioavailability of minerals and trace elements from milk and beverages in humans. Nahrung/Food 2000, 44(6):390-7.
10. Ellis PR, Roberts FG, Low AG, Morgan LM. The effect of high-molecular-weight guar gum on net apparent glucose-absorption and net apparent insulin and gastric-inhibitory polypeptide production in the growing pig: relationship to rheological changes in jejunal digesta. Br J Nutr 1995, 74(4):539-56.
11. Foster TJ, Norton IT. Self-assembling structures in the gastrointestinal tract. Designing functional foods: measuring and controlling food structure breakdown and nutrient absorption 2009, 601-22. McClements DJ, Decker EA. In, editors, Oxford, Woodhead Publishing Limited, p
12. Ganong W. Review of medical physiology 2005, NY, U.S.A, McGraw-Hill
13. Gres MC, Julian B, Bourrie M, Meunier V, Roques C, Berger M, Boulenc X, Berger Y, Fabre G. Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line. Pharma Res 1998, 15(5):726-33.
14. Guyton AC, Hall JE. Textbook of medical physiology 2005, 11 ed, Saunders
15. Hoad CL, Rayment P, Spiller RC, Marciani L, Alonso BD, Traynor C, Mela DJ, Peters HPF, Gowland PA. In vivo imaging of intragastric gelation and its effect on satiety in humans. J Nutr 2004, 134(9):2293-300.
16. Hoad CL, Rayment P, Cox E, Wright P, Butler M, Spiller R, Gowland P. Investigation of alginate beads for gastro-intestinal functionality, Part 2: In vivo characterisation. Food Hydrocolloid 2009, 23:833-9.
17. Holt S, Carter DC, Heading RC, Prescott LF, Tothill P. Effect of gel fiber on gastric-emptying and absorption of glucose and paracetamol. Lancet 1979, 1(8117):636-9.
18. Jarjis HA, Blackburn NA, Redfern JS, Read NW. The effect of ispaghula (fybogel and metamucil) and guar gum on glucose-tolerance in man. Br J Nutr 1984, 51(3):371-8.
19. Jeffrey B, Udaykumar HS, Schulze KS. Flow fields generated by peristaltic reflex in isolated guinea pig ileum: impact of contraction depth and shoulders. Am J Physiol Gastrointest Liver Physiol 2003, 285(5):G907-18.
20. Jenkins DJA, Ghafari H, Wolever TMS, Taylor RH, Jenkins AL, Barker HM, Fielden H, Bowling AC. Relationship between rate of digestion of foods and post-prandial glycemia. Diabetologia 1982, 22(6):450-5.
21. Johnson IT, Gee JM. Effect of gel-forming gums on the intestinal unstirred layer and sugar-transport in vitro. Gut 1981, 22(5):398-403.
22. Khanvilkar K, Donovan MD, Flanagan DR. Drug transfer through mucus. Adv Drug Deliv Rev 2001, 48(2-3):173-93.
23. Kong F, Singh RP. A model stomach system to investigate disintegration kinetics of solid foods during gastric digestion. J Food Sci 2008a, 73(5):E202-10.
24. Kong F, Singh RP. Disintegration of solid foods in human stomach. J Food Sci 2008b, 73(5):R67-80.
25. Leger AJ. Mathematical and numerical modelling of digestion in the small intestine 2005, Univ. of Bath, Bath, U.K
26. Lennernas H, Palm K, Fagerholm U, Artursson P. Comparison between active and passive drug transport in human intestinal epithelial (caco-2) cells in vitro and human jejunum in vivo. Int J Pharma 1996, 127(1):103-7.
27. Lesmes U, Beards EJ, Gibson GR, Tuohy KM, Shimoni E. Effects of resistant starch type III polymorphs on human colon microbiota and short chain fatty acids in human gut models. J Agric Food Chem 2008, 56(13):5415-21.
28. Macagno EO, Christensen J, Lee CL. Modeling the effect of wall movement on absorption in the intestine. Am J Physiol Gastroinest Liver Physiol 1982, 243:G541-50.
29. Macierzanka A, Sancho AI, Mills ENC, Rigby NM, Mackie AR. Emulsification alters simulated gastrointestinal proteolysis of beta-casein and beta-lactoglobulin. Soft Matter 2009, 5(3):538-50.
30. Mälkki Y, Virtanen E. Gastrointestinal effects of oat bran and oat gum: a review. Lebensm Wiss Technol 2001, 34(6):337-47.
31. Marciani L, Wickham MSJ, Bush D, Faulks R, Wright J, Fillery-Travis AJ, Spiller RC, Gowland PA. Magnetic resonance imaging of the behaviour of oil-in-water emulsions in the gastric lumen of man. Br J Nutr 2006, 95(2):331-9.
32. Marciani L, Hall N, Pritchard SE, Totman JJ, Hoad CL, Gowland PA, Spiller RC. Soup meal delays gastric emptying, enhances gallbladder contraction and increases small bowel water content and satiety compared to equicaloric mixed solid/liquid meal. Gut 2009, 58:A30-1.
33. Martini FH. Fundamentals of anatomy & physiology 2006, 7th ed, London, Pearson/Benjamin Cummings
34. Matont A, Hopkins J, McLaughlin CW. Human biology and health 1993, Englewood Cliffs, N.J., Prentice Hall
35. Mercuri A, Faulks R, Craig D, Barker S, Wickham M. Assessing drug release and dissolution in the stomach by means of dynamic gastric model: a biorelevant approach. J Pharm Pharmacol 2009, 61:A5.
36. Norton I, Fryer P, Moore S. Product/process integration in food manufacture: engineering sustained health. AIChE J 2006, 52(5):1632-40.
37. Norton I, Moore S, Fryer P. Obesity Rev 2007, 8(s1):83-8.
38. Owusu-Asiedu A, Patience JF, Laarveld B, Van Kessel AG, Simmins PH, Zijlstra RT. Effects of guar gum and cellulose on digesta passage rate, ileal microbial populations, energy and protein digestibility, and performance of grower pigs. J Anim Sci 2006, 84(4):843-52.
39. Pal A, Indireshkumar K, Schwizer W, Abrahamsson B, Fried M, Brasseur JG. Gastric flow and mixing studied using computer simulation. P Roy Soc London B Bio 2004, 271:2587-94.
40. Probert HM, Gibson GR. Development of a fermentation system to model sessile bacterial populations in the human colon. Biofilms 2004, 1(01):13-9.
41. Rainbird AL, Low AG. Effect of guar gum on gastric-emptying in growing-pigs. Br J Nutr 1986, 55(1):87-98.
42. 2008, http://www.riversideonline.com/source/images/image_popup/d7_digestionsystem.jpg, Riversideonline, Available from
43. Smith ME. The digestive system 2001, Livingstone, Churchill
44. Stoll BR, Batycky RP, Leipold HR, Milstein S, Edwards DA. A theory of molecular absorption from the small intestine. Chem Eng Sci 2000, 55(3):473-89.
45. Stonestreet P, Van Der Veeken PMJ. The effects of oscillatory flow and bulk flow components on residence time distribution in baffled tube reactors. Chem Eng Res Design 1999, 77(8):671-84.
46. Takahashi T, Karita S, Ogawa N, Goto M. Crystalline cellulose reduces plasma glucose concentrations and stimulates water absorption by increasing the digesta viscosity in rats. J Nutr 2005, 135(10):2405-10.
47. Takahashi T, Yokawa T, Ishihara N, Okubo T, Chu D-C, Nishigaki E, Kawada Y, Kato M, Raj Juneja L. Hydrolyzed guar gum decreases postprandial blood glucose and glucose absorption in the rat small intestine. Nutr Res 2009, 29(6):419-25.
48. Thakaran A. Modelling of physical and chemical processes in the small intestine. 2009, Engineering Doctorate Thesis, Univ. of Birmingham, U.K
49. Torsdottir I, Alpsten M, Andersson H, Einarsson S. Dietary guar gum effects on postprandial blood glucose, insulin and hydroxyproline in humans. J Nutr 1989, 119(12):1925-31.
50. Yu LX, Amidon GL. A compartmental absorption and transit model for estimating oral drug absorption. Int J Pharma 1999, 186(2):119-25.