Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors

Brain Research

Volumn 1348, Issue , 2010, Pages 1-9

  Khokhar, Jibran Y ^a   Miksys, Sharon L ^a   Tyndale, Rachel F ^a  

^a NONE

Author keywords

Brain; CYP2B; Induction; Nicotine

Indexed keywords

CHLORISONDAMINE; CYTOCHROME P450 2B; NICOTINE; NICOTINIC RECEPTOR; CYTOCHROME P450 2B1; NICOTINIC AGENT; NICOTINIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CEREBELLUM; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; FRONTAL CORTEX; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANATOMY AND HISTOLOGY; ANIMAL; BRAIN; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; TIME; WISTAR RAT;

ANIMALS; BRAIN; CHLORISONDAMINE; CIRCADIAN RHYTHM; CYTOCHROME P-450 CYP2B1; GENE EXPRESSION REGULATION; MALE; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 77955718138     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.06.035     Document Type: Article

References (39)

1. H.K. Anandatheerthavarada, J.F. Williams, and L. Wecker The chronic administration of nicotine induces cytochrome P450 in rat brain J. Neurochem. 60 1993 1941 1944
2. M.R. Britto, and P.J. Wedlund Cytochrome P-450 in the brain. Potential evolutionary and therapeutic relevance of localization of drug-metabolizing enzymes Drug Metab. Dispos. 20 1992 446 450
3. E. Carstens, C.T. Simons, J.M. Dessirier, M.I. Carstens, and S.L. Jinks Role of neuronal nicotinic-acetylcholine receptors in the activation of neurons in trigeminal subnucleus caudalis by nicotine delivered to the oral mucosa Exp. Brain Res. 132 2000 375 383
4. A. Cepeda-Benito, J. Reynoso, and S.A. Erath Dose-response analyses of associative tolerance to nicotine analgesia in the rat: tail-flick and hot-plate tests Exp. Clin. Psychopharmacol. 8 2000 112 116
5. K.K. Chadman, J.H. Woods, and J. Stitzel Chlorisondamine inhibits the nicotine-induced stimulation of c-fos in the pigeon brain for up to 2 weeks Nicotine Tob. Res. 9 2007 927 936
6. P.B. Clarke, I. Chaudieu, H. el-Bizri, P. Boksa, M. Quik, B.A. Esplin, and R. Capek The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion Br. J. Pharmacol. 111 1994 397 405
7. W.A. Corrigall, K.B. Franklin, K.M. Coen, and P.B. Clarke The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine Psychopharmacology (Berl) 107 1992 285 289
8. S. Ekins, M. Iyer, M.D. Krasowski, and E.D. Kharasch Molecular characterization of CYP2B6 substrates Curr. Drug Metab. 9 2008 363 373
9. H. el-Bizri, and P.B. Clarke Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine Br. J. Pharmacol. 113 1994 917 925
10. H. el-Bizri, M.G. Rigdon, and P.B. Clarke Intraneuronal accumulation and persistence of radiolabel in rat brain following in vivo administration of [3H]-chlorisondamine Br. J. Pharmacol. 116 1995 2503 2509
11. P.J. Fudala, and E.T. Iwamoto Conditioned aversion after delay place conditioning with nicotine Psychopharmacology (Berl) 92 1987 376 381
12. O.A. Ghosheh, L.P. Dwoskin, D.K. Miller, and P.A. Crooks Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2′-(14)C]nicotine Drug Metab. Dispos. 29 2001 645 651
13. L.M. Hesse, P. He, S. Krishnaswamy, Q. Hao, K. Hogan, L.L. von Moltke, D.J. Greenblatt, and M.H. Court Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes Pharmacogenetics 14 2004 225 238
14. P. Jacob III, M. Ulgen, and J.W. Gorrod Metabolism of (-)-(S)-nicotine by guinea pig and rat brain: identification of cotinine Eur. J. Drug Metab. Pharmacokinet. 22 1997 391 394
15. M. Joshi, and R.F. Tyndale Induction and recovery time course of rat brain CYP2E1 after nicotine treatment Drug Metab. Dispos. 34 2006 647 652
16. Y. Kanno, S. Otsuka, T. Hiromasa, T. Nakahama, and Y. Inouye Diurnal difference in CAR mRNA expression Nucl. Recept. 2 2004 6
17. P.J. Kenny, S.E. File, and M. Rattray Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus Brain Res. Mol. Brain Res. 85 2000 234 238
18. L.L. Koenigs, and W.F. Trager Mechanism-based inactivation of cytochrome P450 2B1 by 8-methoxypsoralen and several other furanocoumarins Biochemistry 37 1998 13184 13193
19. R. Kumar, C. Reavill, and I.P. Stolerman Nicotine cue in rats: effects of central administration of ganglion-blocking drugs Br. J. Pharmacol. 90 1987 239 246
20. D.S. McGehee, M.J. Heath, S. Gelber, P. Devay, and L.W. Role Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors Science 269 1995 1692 1696
21. R.P. Meyer, M. Gehlhaus, R. Knoth, and B. Volk Expression and function of cytochrome p450 in brain drug metabolism Curr. Drug Metab. 8 2007 297 306
22. A.L. Micu, S. Miksys, E.M. Sellers, D.R. Koop, and R.F. Tyndale Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism J. Pharmacol. Exp. Ther. 306 2003 941 947
23. S. Miksys, and R.F. Tyndale Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition Neuropsychopharmacology 34 2009 634 640
24. S. Miksys, E. Hoffmann, and R.F. Tyndale Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment Biochem. Pharmacol. 59 2000 1501 1511
25. S. Miksys, Y. Rao, E.M. Sellers, M. Kwan, D. Mendis, and R.F. Tyndale Regional and cellular distribution of CYP2D subfamily members in rat brain Xenobiotica 30 2000 547 564
26. S. Miksys, C. Lerman, P.G. Shields, D.C. Mash, and R.F. Tyndale Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain Neuropharmacology 45 2003 122 132
27. H. Nakayama, H. Okuda, T. Nakashima, S. Imaoka, and Y. Funae Nicotine metabolism by rat hepatic cytochrome P450s Biochem. Pharmacol. 45 1993 2554 2556
28. M.F. O'Neill, C.T. Dourish, and S.D. Iversen Evidence for an involvement of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats Psychopharmacology (Berl) 104 1991 343 350
29. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates. Vol., Academic Press, San Diego.
30. M.R. Picciotto, B.J. Caldarone, S.L. King, and V. Zachariou Nicotinic receptors in the brain. Links between molecular biology and behavior Neuropsychopharmacology 22 2000 451 465
31. C. Reavill, I.P. Stolerman, R. Kumar, and H.S. Garcha Chlorisondamine blocks acquisition of the conditioned taste aversion produced by (-)-nicotine Neuropharmacology 25 1986 1067 1069
32. P.P. Rowell, and M. Li Dose-response relationship for nicotine-induced up-regulation of rat brain nicotinic receptors J. Neurochem. 68 1997 1982 1989
33. B. Schilter, and C.J. Omiecinski Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain Mol. Pharmacol. 44 1993 990 996
34. B. Schilter, M.R. Andersen, C. Acharya, and C.J. Omiecinski Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers J. Pharmacol. Exp. Ther. 294 2000 916 922
35. L.F. Stead, R. Perera, C. Bullen, D. Mant, and T. Lancaster Nicotine replacement therapy for smoking cessation Cochrane Database Syst. Rev. 2008 CD000146
36. I.P. Stolerman, and M.J. Jarvis The scientific case that nicotine is addictive Psychopharmacology (Berl) 117 1995 2 10 discussion 14-20
37. S.C. Upadhya, S.J. Chinta, H.V. Pai, M.R. Boyd, and V. Ravindranath Toxicological consequences of differential regulation of cytochrome p450 isoforms in rat brain regions by phenobarbital Arch. Biochem. Biophys. 399 2002 56 65
38. D.J. Waxman, and L. Azaroff Phenobarbital induction of cytochrome P-450 gene expression Biochem. J. 281 Pt 3 1992 577 592
39. J. Yue, S. Miksys, E. Hoffmann, and R.F. Tyndale Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course J. Psychiatry Neurosci. 33 2008 54 63