Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment

Biochemical Pharmacology

Volumn 59, Issue 12, 2000, Pages 1501-1511

  Miksys, Sharon ^a   Hoffmann, Ewa ^a   Tyndale, Rachel F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Brain; CYP2B; Cytochrome P450; Drug metabolism; Neurotoxicity; Nicotine

Indexed keywords

MESSENGER RNA; NICOTINE; PENTOXYRESORUFIN DEALKYLASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN REGION; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG METABOLISM; ENZYME INDUCTION; FRONTAL CORTEX; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LIVER; MALE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY;

ANIMALS; BRAIN; CYTOCHROME P-450 CYP2B1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER; MALE; NICOTINE; NICOTINIC AGONISTS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0034017040     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00281-1     Document Type: Article

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