Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2′-14C]nicotine

Drug Metabolism and Disposition

Volumn 29, Issue 5, 2001, Pages 645-651

  Ghosheh, Omar A ^a   Dwoskin, Linda P ^a   Miller, Dennis K ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COTININE; NICOTINE; NORNICOTINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BRAIN; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BRAIN LEVEL; METABOLITE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COTININE; MALE; NICOTINE; RADIOMETRY; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; NICOTIANA TABACUM;

EID: 0035036731     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. The chronic administration of nicotine induces cytochrome P450 in rat brain
2. 14C]-labeled nicotine in the brains of mice and cats
3. Nornicotne is self-administered intravenously by rats
4. Pharmacokinetic considerations in understanding nicotine dependence
5. Biomarkers of environmental tobacco smoke exposure
6. Stable isotope studies of nicotine kinetics and bioavaitabitity
7. Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
8. The effects of nicotine on locomotor activity in tolerant and non-tolerant rats
9. Chemical properties of nicotine and other tobacco-related compounds
10. Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking
11. Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: Detection of nornicotine
12. Metabolites of nicoline in rat brain after peripheral nicotine administration: Cotinine, nornicotine and norcotinine
13. S(-)-Nornicotine increases dopamine release in calcium-dependent manner from superfused rat striatal slices
14. Acute and chronic effects of nornicotine on locomotor activity in rats: Altered response to nicotine
15. 3H]dopamine release from rat striatal slices in a calcium-dependent manner
16. Kinetics of nicotine and its metabolites in animals
17. 14C]nicotine
18. Pharmacokinetics of S(-)-nicotine and metabolites in humans
19. Phytochemical studies on tobacco alkaloids. I. Optical rotary power of nomicotine
20. 3H]acetylcholine to nicotinic receptors
21. Metabolism of nicotine
22. Effects of chronic nicotine infusion on tolerance development and nicotinic receptors
23. Regional and cellular induction of nicotine metabolizing CYP2B1 in rat brain by chronic nicotine treatment
24. 11C]-nicotine in the brains of rhesus monkey. An attempt to study nicotinic receptors in vivo
25. A comparative study of the disposition of nicotine and its metabolites in three inbred strains of mice
26. A physiologically based pharmacokinetic model for nicotine disposition in the Sprague Dawley rat
27. 1H-NMR spectroscopy in the presence of 1,1′-binaphthyl-2,2′-diylphosphoric acid
28. Dose-response relationship for nicotine-induced upregulation of rat brain nicotinic receptors
29. Upregulation of nicotinic receptors following continuous infusion of nicotine is brain region specific
30. Distribution of nicotine in central nervous system
31. Effects of increased liver metabolism of nicotine on its uptake, elimination and toxicity in mice
32. Effects of increased liver metabolism of nicotine on its uptake, elimination and toxicity in mice
33. Dissociations between locomotor stimulant and depressant effects of nicotinic agonists in rats
34. A novel enantioselective synthesis of (S)-(-)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketamine template
35. 3H]dopamine
36. 3H]nicotine in dogs and rhesus monkeys
37. Misclassification of smoking status in the CARDIA study: A comparison of self-report with serum cotinine levels
38. Determination of nornicotine in smokers urine by gas chromatography following reductive alkylation to N′-propyl nornicotine