-
1
-
-
65649153346
-
Tumor suppressor and oncogene actions of TGFbeta1 occur early in skin carcinogenesis and are mediated by Smad3
-
Bae DS, Blazanin N, Licata M et al. (2009) Tumor suppressor and oncogene actions of TGFbeta1 occur early in skin carcinogenesis and are mediated by Smad3. Mol Carcinog 48:441-453
-
(2009)
Mol Carcinog
, vol.48
, pp. 441-453
-
-
Bae, D.S.1
Blazanin, N.2
Licata, M.3
-
2
-
-
0037085768
-
Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism
-
Benchetrit F, Ciree A, Vives V et al. (2002) Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism. Blood 99:2114-2121
-
(2002)
Blood
, vol.99
, pp. 2114-2121
-
-
Benchetrit, F.1
Ciree, A.2
Vives, V.3
-
3
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
4
-
-
34547878575
-
Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion
-
Darwiche N, Ryscavage A, Perez-Lorenzo R et al. (2007) Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion. Oncogene 26:6885-6895
-
(2007)
Oncogene
, vol.26
, pp. 6885-6895
-
-
Darwiche, N.1
Ryscavage, A.2
Perez-Lorenzo, R.3
-
6
-
-
0028609621
-
Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha
-
Dlugosz AA, Cheng C, Williams EK et al. (1994) Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha. Cancer Res 54:6413-6420
-
(1994)
Cancer Res
, vol.54
, pp. 6413-6420
-
-
Dlugosz, A.A.1
Cheng, C.2
Williams, E.K.3
-
7
-
-
70349148301
-
Inflammatory skin disease in K5.hTGF-beta1 transgenic mice is not dependent on the IL-23/Th17 inflammatory pathway
-
Fitch EL, Rizzo HL, Kurtz SE et al. (2009) Inflammatory skin disease in K5.hTGF-beta1 transgenic mice is not dependent on the IL-23/Th17 inflammatory pathway. J Invest Dermatol 129:2443-2450
-
(2009)
J Invest Dermatol
, vol.129
, pp. 2443-2450
-
-
Fitch, E.L.1
Rizzo, H.L.2
Kurtz, S.E.3
-
8
-
-
69249222379
-
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "n1" versus "n2" TAN
-
Fridlender ZG, Sun J, Kim S et al. (2009) Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 16:183-194
-
(2009)
Cancer Cell
, vol.16
, pp. 183-194
-
-
Fridlender, Z.G.1
Sun, J.2
Kim, S.3
-
9
-
-
33644779729
-
Immunosurveillance and immunoregulation by gammadelta T cells
-
Girardi M (2006) Immunosurveillance and immunoregulation by gammadelta T cells. J Invest Dermatol 126:25-31
-
(2006)
J Invest Dermatol
, vol.126
, pp. 25-31
-
-
Girardi, M.1
-
10
-
-
15244340251
-
TGFbeta1, back to the future: Revisiting its role as a transforming growth factor
-
Glick AB (2004) TGFbeta1, back to the future: revisiting its role as a transforming growth factor. Cancer Biol Ther 3:276-283
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 276-283
-
-
Glick, A.B.1
-
11
-
-
0034770605
-
Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells
-
Gorelik L, Flavell RA (2001) Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med 7:1118-1122
-
(2001)
Nat Med
, vol.7
, pp. 1118-1122
-
-
Gorelik, L.1
Flavell, R.A.2
-
13
-
-
68649104004
-
Gammadelta T cells and the lymphoid stress-surveillance response
-
Hayday AC (2009) Gammadelta T cells and the lymphoid stress-surveillance response. Immunity 31:184-196
-
(2009)
Immunity
, vol.31
, pp. 184-196
-
-
Hayday, A.C.1
-
14
-
-
0027496668
-
FVB/N mice: An inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin
-
Hennings H, Glick AB, Lowry DT et al. (1993) FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis 14:2353-2358
-
(1993)
Carcinogenesis
, vol.14
, pp. 2353-2358
-
-
Hennings, H.1
Glick, A.B.2
Lowry, D.T.3
-
15
-
-
33748889496
-
Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice
-
HogenEsch H, Dunham A, Seymour R et al. (2006) Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice. Exp Dermatol 15:808-814
-
(2006)
Exp Dermatol
, vol.15
, pp. 808-814
-
-
Hogenesch, H.1
Dunham, A.2
Seymour, R.3
-
16
-
-
68049097199
-
Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis
-
Ito Y, Usui T, Kobayashi S et al. (2009) Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis. Arthritis Rheum 60:2294-2303
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2294-2303
-
-
Ito, Y.1
Usui, T.2
Kobayashi, S.3
-
17
-
-
0032055597
-
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages
-
Jovanovic DV, Di Battista JA, Martel-Pelletier J et al. (1998) IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol 160:3513-3521
-
(1998)
J Immunol
, vol.160
, pp. 3513-3521
-
-
Jovanovic, D.V.1
Di Battista, J.A.2
Martel-Pelletier, J.3
-
18
-
-
5644277476
-
Interleukin-17 family members and inflammation
-
Kolls JK, Linden A (2004) Interleukin-17 family members and inflammation. Immunity 21:467-476
-
(2004)
Immunity
, vol.21
, pp. 467-476
-
-
Kolls, J.K.1
Linden, A.2
-
19
-
-
33846889522
-
A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis
-
Krueger GG, Langley RG, Leonardi C et al. (2007) A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 356:580-592
-
(2007)
N Engl J Med
, vol.356
, pp. 580-592
-
-
Krueger, G.G.1
Langley, R.G.2
Leonardi, C.3
-
20
-
-
69849107597
-
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
-
Kryczek I, Banerjee M, Cheng P et al. (2009a) Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 114:1141-1149
-
(2009)
Blood
, vol.114
, pp. 1141-1149
-
-
Kryczek, I.1
Banerjee, M.2
Cheng, P.3
-
21
-
-
67651094058
-
Endogenous IL-17 contributes to reduced tumor growth and metastasis
-
Kryczek I, Wei S, Szeliga W et al. (2009b) Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood 114:357-359
-
(2009)
Blood
, vol.114
, pp. 357-359
-
-
Kryczek, I.1
Wei, S.2
Szeliga, W.3
-
22
-
-
34249806717
-
Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
-
Kryczek I, Wei S, Zou L et al. (2007) Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol 178:6730-6733
-
(2007)
J Immunol
, vol.178
, pp. 6730-6733
-
-
Kryczek, I.1
Wei, S.2
Zou, L.3
-
23
-
-
33746534417
-
IL-23 promotes tumour incidence and growth
-
Langowski JL, Zhang X, Wu L et al. (2006) IL-23 promotes tumour incidence and growth. Nature 442:461-465
-
(2006)
Nature
, vol.442
, pp. 461-465
-
-
Langowski, J.L.1
Zhang, X.2
Wu, L.3
-
24
-
-
0031944290
-
Regulation of immune responses by TGF-beta
-
Letterio JJ, Roberts AB (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol 16:137-161
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 137-161
-
-
Letterio, J.J.1
Roberts, A.B.2
-
25
-
-
2442548490
-
Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder
-
Li AG, Wang D, Feng XH et al. (2004) Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J 23:1770-1781
-
(2004)
EMBO J
, vol.23
, pp. 1770-1781
-
-
Li, A.G.1
Wang, D.2
Feng, X.H.3
-
26
-
-
33646164362
-
Transforming growth factor-beta regulation of immune responses
-
Li MO, Wan YY, Sanjabi S et al. (2006) Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24:99-146
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 99-146
-
-
Li, M.O.1
Wan, Y.Y.2
Sanjabi, S.3
-
27
-
-
0035979272
-
Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia
-
Liu X, Alexander V, Vijayachandra K et al. (2001) Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia. Proc Natl Acad Sci USA 98:9139-9144
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9139-9144
-
-
Liu, X.1
Alexander, V.2
Vijayachandra, K.3
-
28
-
-
3042778716
-
Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation
-
Lu SL, Reh D, Li AG et al. (2004) Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation. Cancer Res 64:4405-4410
-
(2004)
Cancer Res
, vol.64
, pp. 4405-4410
-
-
Lu, S.L.1
Reh, D.2
Li, A.G.3
-
29
-
-
0037934497
-
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells
-
Lugo-Villarino G, Maldonado-Lopez R, Possemato R et al. (2003) T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci USA 100:7749-7754
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7749-7754
-
-
Lugo-Villarino, G.1
Maldonado-Lopez, R.2
Possemato, R.3
-
30
-
-
33646560950
-
Transforming growth factor-beta induces development of the T(H)17 lineage
-
Mangan PR, Harrington LE, O'Quinn DB et al. (2006) Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441:231-234
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O'Quinn, D.B.3
-
31
-
-
70449530422
-
T helper 17 cells promote cytotoxic T cell activation in tumor immunity
-
Martin-Orozco N, Muranski P, Chung Y et al. (2009) T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31:787-798
-
(2009)
Immunity
, vol.31
, pp. 787-798
-
-
Martin-Orozco, N.1
Muranski, P.2
Chung, Y.3
-
32
-
-
43249130187
-
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
-
Movahedi K, Guilliams M, Van den BJ et al. (2008) Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 111:4233-4244
-
(2008)
Blood
, vol.111
, pp. 4233-4244
-
-
Movahedi, K.1
Guilliams, M.2
Van Den, B.J.3
-
33
-
-
47649122633
-
Tumor-specific Th17-polarized cells eradicate large established melanoma
-
Muranski P, Boni A, Antony PA et al. (2008) Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112:362-373
-
(2008)
Blood
, vol.112
, pp. 362-373
-
-
Muranski, P.1
Boni, A.2
Antony, P.A.3
-
34
-
-
70449585536
-
Does IL-17 promote tumor growth?
-
Muranski P, Restifo NP (2009) Does IL-17 promote tumor growth? Blood 114:231-232
-
(2009)
Blood
, vol.114
, pp. 231-232
-
-
Muranski, P.1
Restifo, N.P.2
-
35
-
-
0029835016
-
In situ apoptotic cell labeling by the TUNEL method: Improvement and evaluation on cell preparations
-
Negoescu A, Lorimier P, Labat-Moleur F et al. (1996) In situ apoptotic cell labeling by the TUNEL method: improvement and evaluation on cell preparations. J Histochem Cytochem 44:959-968
-
(1996)
J Histochem Cytochem
, vol.44
, pp. 959-968
-
-
Negoescu, A.1
Lorimier, P.2
Labat-Moleur, F.3
-
36
-
-
54249130813
-
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
-
Nograles KE, Zaba LC, Guttman-Yassky E et al. (2008) Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br J Dermatol 159:1092-1102
-
(2008)
Br J Dermatol
, vol.159
, pp. 1092-1102
-
-
Nograles, K.E.1
Zaba, L.C.2
Guttman-Yassky, E.3
-
39
-
-
0022977903
-
An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue
-
Roop DR, Lowy DR, Tambourin PE et al. (1986) An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 323:822-824
-
(1986)
Nature
, vol.323
, pp. 822-824
-
-
Roop, D.R.1
Lowy, D.R.2
Tambourin, P.E.3
-
40
-
-
40949127761
-
Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: Role in skin carcinogenesis
-
Shukla A, Ho Y, Liu X et al. (2008) Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesis. Mol Cancer Res 6:509-516
-
(2008)
Mol Cancer Res
, vol.6
, pp. 509-516
-
-
Shukla, A.1
Ho, Y.2
Liu, X.3
-
41
-
-
0347994894
-
Antigen-driven effector CD8 T cell function regulated by T-bet
-
Sullivan BM, Juedes A, Szabo SJ et al. (2003) Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci USA 100:15818-15823
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15818-15823
-
-
Sullivan, B.M.1
Juedes, A.2
Szabo, S.J.3
-
42
-
-
68649088121
-
Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
-
Sutton CE, Lalor SJ, Sweeney CM et al. (2009) Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31:331-341
-
(2009)
Immunity
, vol.31
, pp. 331-341
-
-
Sutton, C.E.1
Lalor, S.J.2
Sweeney, C.M.3
-
43
-
-
0242285692
-
TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
-
Tang B, Vu M, Booker T et al. (2003) TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest 112:1116-1124
-
(2003)
J Clin Invest
, vol.112
, pp. 1116-1124
-
-
Tang, B.1
Vu, M.2
Booker, T.3
-
44
-
-
0347626102
-
Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines
-
Tian F, DaCosta BS, Parks WT et al. (2003) Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res 63:8284-8292
-
(2003)
Cancer Res
, vol.63
, pp. 8284-8292
-
-
Tian, F.1
Dacosta, B.S.2
Parks, W.T.3
-
45
-
-
0025055406
-
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance
-
Torre-Amione G, Beauchamp RD, Koeppen H et al. (1990) A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. Proc Natl Acad Sci USA 87:1486-1490
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 1486-1490
-
-
Torre-Amione, G.1
Beauchamp, R.D.2
Koeppen, H.3
-
46
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M, Hocking RJ, Atkins CJ et al. (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-189
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
-
47
-
-
67650495415
-
IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
-
Wang L, Yi T, Kortylewski M et al. (2009) IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 206:1457-1464
-
(2009)
J Exp Med
, vol.206
, pp. 1457-1464
-
-
Wang, L.1
Yi, T.2
Kortylewski, M.3
-
48
-
-
62449162980
-
IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation
-
Xiao M, Wang C, Zhang J et al. (2009) IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation. Cancer Res 69:2010-2017
-
(2009)
Cancer Res
, vol.69
, pp. 2010-2017
-
-
Xiao, M.1
Wang, C.2
Zhang, J.3
-
49
-
-
0036087521
-
Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects
-
Yang YA, Dukhanina O, Tang B et al. (2002) Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects. J Clin Invest 109:1607-1615
-
(2002)
J Clin Invest
, vol.109
, pp. 1607-1615
-
-
Yang, Y.A.1
Dukhanina, O.2
Tang, B.3
-
50
-
-
54049134747
-
Subsets of myeloid-derived suppressor cells in tumor-bearing mice
-
Youn JI, Nagaraj S, Collazo M et al. (2008) Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 181:5791-5802
-
(2008)
J Immunol
, vol.181
, pp. 5791-5802
-
-
Youn, J.I.1
Nagaraj, S.2
Collazo, M.3
|