Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-β1 signaling: Role in skin carcinogenesis

Molecular Cancer Research

Volumn 6, Issue 3, 2008, Pages 509-516

  Shukla, Anjali ^a   Ho, Yan ^a   Liu, Xin ^a   Ryscavage, Andrew ^a   Glick, Adam B ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; BIOLOGICAL MARKER; CRIPTO 1 PROTEIN; CYTOKERATIN 1; CYTOKERATIN 8; EPIDERMAL GROWTH FACTOR; LUCIFERASE; PROTEIN TYROSINE KINASE INHIBITOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR PROMOTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STAGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDERMIS; KERATINOCYTE; MOUSE; NEWBORN; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; REPORTER GENE; SENESCENCE; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN CARCINOGENESIS; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; UPREGULATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; DNA REPLICATION; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; KERATINOCYTES; MEMBRANE GLYCOPROTEINS; MICE; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 40949127761     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-07-0396     Document Type: Article

References (37)

1. Shen MM, Schier AF. The EGF-CFC gene family in vertebrate development. Trends Genet 2000;16:303-9.
2. Saloman DS, Bianco C, Ebert AD, et al. The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer. Endocr Relat Cancer 2000;7:199-226.
3. Minchiotti G, Parisi S, Liguori G, et al. Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development. Mech Dev 2000;90:133-42.
4. Bianco C, Normanno N, De Luca A, et al. Detection and localization of Cripto-1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin-cripto-1 fusion protein. J Cell Physiol 2002;190:74-82.
5. Xu C, Liguori G, Persico MG, Adamson ED. Abrogationof the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development 1999;126:483-94.
6. Bamford RN, Roessler E, Burdine RD, et al. Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. Nat Genet 2000;26:365-9.
7. Beddington RS, Robertson EJ. Axis development and early asymmetry in mammals. Cell 1999;96:195-209.
8. Colas JF, Schoenwolf GC. Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis. Gene 2000;255:205-17.
9. Ding J, Yang L, Yan YT, et al. Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature 1998;395:702-7.
10. Schier AF, Shen MM. Nodal signalling in vertebrate development. Nature 2000;403:385-9.
11. Yeo C, Whitman M. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell 2001;7:949-57.
12. Gray PC, Harrison CA, Vale W. Cripto forms a complex with activin and type II activin receptors and can block activin signaling. Proc Natl Acad Sci U S A 2003;100:5193-8.
13. Gray PC, Shani G, Aung K, Kelber J, Vale W. Cripto binds transforming growth factor β (TGF-β) and inhibits TGF-β signaling. Mol Cell Biol 2006;26:9268-78.
14. Strizzi L, Bianco C, Normanno N, Salomon D. Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis. Oncogene 2005;24:5731-41.
15. Wechselberger C, Ebert AD, Bianco C, et al. Cripto-1 enhances migration and branching morphogenesis of mouse mammary epithelial cells. Exp Cell Res 2001;266:95-105.
16. Wechselberger C, Strizzi L, Kenney N, et al. Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma. Oncogene 2005;24:4094-105.
17. Liu X, Lee J, Cooley M, Bhogte E, Hartley S, Glick A. Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma. Cancer Res 2003;63:7760-8.
18. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 1980;19:245-54.
19. Jonk LJ, Itoh S, Heldin CH, Ten DP, Kruijer W. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer. J Biol Chem 1998;273:21145-52.
20. Glick AB, Danielpour D, Morgan D, Sporn MB, Yuspa SH. Induction and autocrine receptor binding of transforming growth factor-β2 during terminal differentiation of primary mouse keratinocytes. Mol Endocrinol 1990;4:46-52.
21. Tremain R, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A. Defects in TGF-β signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene 2000;19:1698-709.
22. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent humancells inculture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995;92:9363-7.
23. Yuspa SH, Kilkenny AE, Steinert PM, Roop DR. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol 1989;109:1207-17.
24. Yuspa SH, Kilkenny A, Cheng C, et al. Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis. Environ Health Perspect 1991;93:3-10.
25. Larcher F, Bauluz C, Diaz-Guerra M, et al. Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas. Mol Carcinog 1992;6:112-21.
26. Markey AC, Lane EB, Churchill LJ, MacDonald DM, Leigh IM. Expression of simple epithelial keratins 8 and 18 in epidermal neoplasia. J Invest Dermatol 1991;97:763-70.
27. Glick AB, Danielpour D, Morgan D, Sporn MB, Yuspa SH. Induction and autocrine receptor binding of transforming growth factor-b2 during terminal differentiation of primary mouse keratinocytes. Mol Endocrinol 1990;4:46-52.
28. Cheng C, Tennenbaum T, Dempsey PJ, Coffey RJ, Yuspa SH, Dlugosz AA. Epidermal growth factor receptor ligands regulate keratin 8 expression in keratinocytes, and transforming growth factor a mediates the induction of keratin 8 by the v-rasHa oncogene. Cell Growth Differ 1993;4:317-27.
29. Dlugosz AA, Cheng C, Denning MF, Dempsey PJ, Coffey RJ, Jr., Yuspa SH. Keratinocyte growth factor-receptor ligands induce transforming growth factor a expression and activate the epidermal growth factor-receptor signaling pathway incultured epidermal keratinocytes. Cell Growth Differ 1994;5:1283-92.
30. Glick AB, Kulkarni AB, Tennenbaum T, et al. Loss of expression of transforming growth factor β inskinan d skintumors is associated with hyperproliferation and a high risk for malignant conversion. Proc Natl Acad Sci U S A 1993;90:6076-80.
31. Vijayachandra K, Lee J, Glick AB. Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model. Cancer Res 2003;63:3447-52.
32. Dlugosz AA, Glick AB, Tennenbaum T, Weinberg WC, Yuspa SH. Isolation and utilization of epidermal keratinocytes for oncogene research. Methods Enzymol 1995;254:3-20.
33. Seno M, DeSantis M, Kannan S, et al. Purification and characterization of a recombinant human cripto-1 protein. Growth Factors 1998;15:215-29.
34. Hennings H, Shores R, Mitchell P, Spangler EF, Yuspa SH. Induction of papillomas with a high probability of conversion to malignancy. Carcinogenesis 1985;6:1607-10.
35. Cataisson C, Pearson AJ, Tsien MZ, et al. CXCR2 ligands and G-CSF mediate PKCα-induced intraepidermal inflammation. J Clin Invest 2006;116:2757-66.
36. Danielpour D. Iodination of TGF-β, TGF-β-receptor cross-linking, and immunoprecipitation of TGF-β-receptor complexes. Methods Mol Biol 2000;142:29-37.
37. Roop DR, Lowy DR, Tambourin PE, et al. An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 1986;323:822-4.