Increased sensitivity of Aspergillus flavus and Aspergillus parasiticus aflatoxin biosynthesis polyketide synthase mutants to UVB light

World Mycotoxin Journal

Volumn 3, Issue 3, 2010, Pages 263-270

  Ehrlich, K C ^a   Wei, Q ^a   Bhatnagar, D ^a  

^a SOUTHERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

Aflatoxin biosynthesis; Biocontrol; Fungal competition; Fungal spores; Gene disruption

Indexed keywords

AFLATOXIN; MUTANT PROTEIN; OLIGONUCLEOTIDE; POLYKETIDE SYNTHASE;

ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS PARASITICUS; CELL VIABILITY; FUNGAL STRAIN; GENE CLUSTER; GENE DELETION; GENE MUTATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN FOLDING; PROTEIN SYNTHESIS; ULTRAVIOLET B RADIATION;

EID: 77955696483     PISSN: 18750710     EISSN: 18750796     Source Type: Journal    
DOI: 10.3920/WMJ2010.1218     Document Type: Article

References (48)

1. Atehnkeng, J., Ojiambo, P.S., Ikotun, T., Sikora, R.A., Cotty, P.J. and Bandyopadhyay, R., 2008. Evaluation of atoxigenic isolates of Aspergillus flavus as potential biocontrol agents for aflatoxin in maize. Food Additives and Contaminants: Part A 25: 1264-1271.
2. Aziz, N.H. and Moussa, L.A., 1997. Influence of white light, near-UV irradiation and other environmental conditions on production of aflatoxin B1 by Aspergillus flavus and ochratoxin A by Aspergillus ochraceus. Nahrung 41: 150-154.
3. Bayram, O., Krappmann, S., Ni, M., Bok, J.W., Helmstaedt, K., Valerius, O., Braus-Stromeyer, S., Kwon, N.J., Keller, N.P., Yu, J.H. and Braus, G.H., 2008. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320: 1504-1506.
4. Bhatnagar, D., Rajasekaran, K., Payne, G.A., Brown, R.L., Yu, J. and Cleveland, T.E., 2008. The 'omics' tools: genomics, proteomics, metabolomics and their potential for solving the aflatoxin contamination problem. World Mycotoxin Journal 1: 3-12.
5. Braga, G.U., Flint, S.D., Messias, C.L., Anderson, A.J. and Roberts, D.W., 2001a. Effects of UVB irradiance on conidia and germinants of the entomopathogenic Hyphomycete Metarhizium anisopliae: a study of reciprocity and recovery. Photochemistry and Photobiology 73: 140-146.
6. Braga, G.U., Flint, S.D., Miller, C.D., Anderson, A.J. and Roberts, D.W., 2001b. Both solar UVA and UVB radiation impair conidial culturability and delay germination in the entomopathogenic fungus Metarhizium anisopliae. Photochemistry and Photobiology 74: 734-739.
7. Braga, G.U., Flint, S.D., Miller, C.D., Anderson, A.J. and Roberts, D.W., 2001c. Variability in response to UV-B among species and strains of Metarhizium isolated from sites at latitudes from 61 degrees N to 54 degrees S. Journal of Invertebrate Pathology 78: 98-108.
8. Braga, G.U., Rangel, D.E., Flint, S.D., Anderson, A.J. and Roberts, D.W., 2006. Conidial pigmentation is important to tolerance against solar-simulated radiation in the entomopathogenic fungus Metarhizium anisopliae. Photochemistry and Photobiology 82: 418-422.
9. Calvo, A.M., Bok, J., Brooks, W. and Keller, N.P., 2004. veA is required for toxin and sclerotial production in Aspergillus parasiticus. Applied and Environmental Microbiology 70: 4733-4739.
10. Calvo, A.M., Wilson, R.A., Bok, J.-W. and Keller, N.P., 2002. Relationship between secondary metabolism and fungal development. Microbiology and Molecular Biology Reviews 66: 447-459.
11. Carroll, G.C. and Wicklow, D.T. (eds.), 1992. The fungal community: its organization and role in the ecosystem. Mycology Series, Vol.9. Marcel Dekker, New York, NY, USA. 972 pp.
12. Chang, P.-K., Bennett, J.W. and Cotty, P.J., 2002. Association of aflatoxin biosynthesis and sclerotial development in Aspergillus parasiticus. Mycopathologia 153: 41-48.
13. Chang, P.-K., Ehrlich, K.C., Linz, J.E., Bhatnagar, D., Cleveland, T.E. and Bennett, J.W., 1996. Characterization of the Aspergillus parasiticus niaD and niiA gene cluster. Current Genetics 30: 68-75.
14. Chang, P.K., Cary, J.W., Yu, J., Bhatnagar, D. and Cleveland, T.E., 1995. The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1 biosynthesis. Molecular and General Genetics 248: 270-277.
15. Chipley, J.R., Story, L.D., Todd, P.T. and Kabara, J.J., 1981. Inhibition of Aspergillus growth and extracellular aflatoxin accumulation by sorbic acid and derivatives of fatty acids. Journal of Food Safety 3: 109-120.
16. Chu, F.S. and Bhatnagar, D., 2004. Mycotoxins. In: D.K. Arora (ed.) Fungal biotechnology in agricultural, food, and environment applications. Marcel Dekker Inc., New York, NY, USA, pp. 325-342.
17. Cole, R., Schweikert, M. and Jarvis, B., 2003. Handbook of secondary fungal metabolites. Elsevier/Academic Press, Maryland Heights, MO, USA. 2498 pp.
18. Cotty, P.J. and Bayman, P., 1993. Competitive exclusion of a toxigenic strain of Aspergillus flavus by an atoxigenic strain. Phytopathology 83: 1283-1287.
19. Cotty, P.J. and Mellon, J.E., 2006. Ecology of aflatoxin producing fungi and biocontrol of aflatoxin contamination. Mycotoxin Research 22: 110-117.
20. Dorner, J.W., 2004. Biological control of aflatoxin contamination of crops. Journal of Toxicology-Toxin Reviews 23: 425-450.
21. Dorner, J.W., 2009. Biological control of aflatoxin contamination in corn using a nontoxigenic strain of Aspergillus flavus. Journal of Food Protection 72: 801-804.
22. Dorner, J.W., Cole, R.J., Connick, W.J., Daigle, D.J., McGuire, M.R. and Shasha, B.S., 2003. Evaluation of biological control formulations to reduce aflatoxin contamination in peanuts. Biological Control 26: 318-324.
23. Dorner, J.W., Cole, R.J. and Wicklow, D.T., 1999. Aflatoxin reduction in corn through field application of competitive fungi. Journal of Food Protection 62: 650-656.
24. Ehrlich, K.C., 2006. Evolution of the aflatoxin gene cluster. Mycotoxin Research 22: 9-15.
25. Ehrlich, K.C., 2008. Genetic diversity in Aspergillus flavus and its implications for agriculture. In: Varga, J. and Samson, R.A. (eds.) Aspergillus in the genomic era. Wageningen Academic Publishers, Wageningen, the Netherlands, pp. 233-247.
26. Ehrlich, K.C., Chang, P.-K., Yu, J. and Cotty, P.J., 2004. Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation. Applied and Environmental Microbiology 70: 6518-6524.
27. Elias, K.S. and Cotty, P.J., 1994. A rose bengal amended medium for selecting nitrate-metabolism mutants from fungi. Canadian Journal of Botany 73: 680-692.
28. Georgianna, D.R., Fedorova, N.D., Burroughs, J.L., Dolezal, A.L., Bok, J.W., Horowitz-Brown, S., Woloshuk, C.P., Yu, J.J., Keller, N.P. and Payne, G.A., 2010. Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters. Molecular Plant Pathology 11: 213-226.
29. Gomez, B.L. and Nosanchuk, J.D., 2003. Melanin and fungi. Current Opinion in Infectious Diseases 16: 91-96.
30. Gorbushina, A., 2003. Microcolonial fungi: survival potential of terrestrial vegetative structures. Astrobiology 3: 543-554.
31. Horn, B.W. and Dorner, J.W., 1999. Regional differences in production of aflatoxin B1 and cyclopiazonic acid by soil isolates of Aspergillus flavus along a transect within the United States. Applied and Environmental Microbiology 65: 1444-1449.
32. Horn, B.W., Greene, R.L. and Dorner, J.W., 2000. Inhibition of aflatoxin B-1 production by Aspergillus parasiticus using nonaflatoxigenic strains: role of vegetative compatibility. Biological Control 17: 147-154.
33. Horn, B.W., Greene, R.L., Sorensen, R.B., Blankenship, P.D. and Dorner, J.W., 2001. Conidial movement of nontoxigenic Aspergillus flavus and A. parasiticus in peanut fields following application to soil. Mycopathologia 151: 81-92.
34. Klich, M.A., 2002. Biogeography of Aspergillus species in soil and litter. Mycologia 94: 21-27.
35. Pildain, M.B., Vaamonde, G. and Cabral, D., 2004. Analysis of population structure of Aspergillus flavus from peanut based on vegetative compatibility, geographic origin, mycotoxin and sclerotia production. International Journal of Food Microbiology 93: 31-40.
36. Ramakrishna, N., Lacey, J. and Smith, J.E., 1996a. Aspergillus flavus colonization and aflatoxin B-1 formation in barley grain during interaction with other fungi. Mycopathologia 136: 53-63.
37. Ramakrishna, N., Lacey, J. and Smith, J.E., 1996b. The effects of fungal competition on colonization of barley grain by Fusarium sporotrichioides on T-2 toxin formation. Food Additives and Contaminants 13: 939-948.
38. Vaamonde, G., Patriarca, A., Fernandez Pinto, V., Comerio, R. and Degrossi, C., 2003. Variability of aflatoxin and cyclopiazonic acid production by Aspergillus section flavi from different substrates in Argentina. International Journal of Food Microbiology 88: 79-84.
39. Valero, A., Begum, M., Leong, S.L., Hocking, A.D., Ramos, A.J., Sanchis, V. and Marin, S., 2007. Effect of germicidal UVC light on fungi isolated from grapes and raisins. Letters in Applied Microbiology 45: 238-243.
40. Wieser, J., Yu, J.H. and Adams, T.H., 1997. Dominant mutations affecting both sporulation and sterigmatocystin biosynthesis in Aspergillus nidulans. Current Genetics 32: 218-224.
41. Wilkinson, H., Ramaswamy, A., Sim, S.C. and Keller, N.P., 2004. Increased conidiation associated with progression along the sterigmatocystin biosynthetic pathway. Mycologia 96: 1190-1198.
42. Wu, F., Liu, Y. and Bhatnagar, D., 2008. Cost-effectiveness of aflatoxin control methods: economic incentives. Toxin Reviews 27: 203-225.
43. Yin, Y.N., Yan, L.Y., Jiang, J.H. and Ma, Z.H., 2008. Biological control of aflatoxin contamination of crops. Journal of Zhejiang University Science B 9: 787-792.
44. Yu, J., Bhatnagar, D. and Cleveland, T.E., 2004. Completed sequence of the aflatoxin pathway gene cluster in Aspergillus parasiticus. FEBS Letters 564: 126-130.
45. Yu, J., Bhatnagar, D. and Ehrlich, K.C., 2002. Aflatoxin biosynthesis. Revista Iberoamericana de Micología 19: 191-200.
46. Yu, J., Chang, P.K., Cary, J.W., Bhatnagar, D. and Cleveland, T.E., 1997. avnA, a gene encoding a cytochrome P-450 monooxygenase, is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus. Applied and Environmental Microbiology 63: 1349-1356.
47. Yu, J., Woloshuk, C.P., Bhatnagar, D. and Cleveland, T.E., 2000. Cloning and characterization of avfA and omtB genes involved in aflatoxin biosynthesis in three Aspergillus species. Gene 248: 157-167.
48. Yu, J.H. and Leonard, T.J., 1995. Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase. Journal of Bacteriology 177: 4792-4800.