Characterization of the Aspergillus parasiticus niaD and niiA gene cluster

Current Genetics

Volumn 30, Issue 1, 1996, Pages 68-75

  Chang, Perng Kuang ^a   Ehrlich, Kenneth C ^b   Linz, John E ^c   Bhatnagar, Deepak ^b   Cleveland, Thomas E ^b   Bennett, Joan W ^a  

^a Tulane University   (United States)

^b SOUTHERN REGIONAL RESEARCH CENTER   (United States)

^c Michigan State University   (United States)

Author keywords

Aspergillus parasiticus; Gene cluster; Nitrate reductase; Nitrite reductase

Indexed keywords

DNA BINDING PROTEIN; FLAVINE ADENINE NUCLEOTIDE; FUNGAL PROTEIN; HEME; MOLYBDENUM; NITRATE REDUCTASE; NITRITE REDUCTASE; RECOMBINANT PROTEIN; REGULATOR PROTEIN; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; ASPERGILLUS; ASPERGILLUS PARASITICUS; BINDING SITE; ENZYME STRUCTURE; FUNGAL GENETICS; FUSARIUM OXYSPORUM; GENE CLUSTER; GENE STRUCTURE; GIBBERELLA FUJIKUROI; NEUROSPORA CRASSA; NITROGEN METABOLISM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ASPERGILLUS; BASE SEQUENCE; BINDING SITES; DNA PRIMERS; DNA, FUNGAL; FUNGAL PROTEINS; GENES, FUNGAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NITRATE REDUCTASE; NITRATE REDUCTASES; NITRITE REDUCTASES; RESTRICTION MAPPING; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

ASPERGILLUS ORYZAE; ASPERGILLUS PARASITICUS; FUSARIUM; FUSARIUM OXYSPORUM; GIBBERELLA; GIBBERELLA FUJIKUROI; LEPTOSPHAERIA; LEPTOSPHAERIA MACULANS; NEUROSPORA CRASSA;

EID: 0030018354     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050102     Document Type: Article

References (52)

1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410
2. Ballance DJ (1986) Sequences important for gene expression in filamentous fungi. Yeast 2:229-236
3. Bennett JW, Rubin PL, Lee LS, Chen NP (1979) Influence of trace elements and nitrogen sources on versicolorin production by a mutant strain of Aspergillus parasiticus. Mycopathologia 69:161-166
4. Brownlee AG, Arst HN Jr (1983) Nitrate uptake in Aspergillus nidulans and involvement of the third gene of the nitrate assimilation gene cluster. J Bacteriol 115:1138-1146
5. Bruckner B, Mende K, Weltring K, Kinghorn JR, Unkles SE (1996) The Gibberella fujikuroi niaD gene encoding nitrate reductase: isolation, gene structure, homologous transformation and electrophoretic karyotype location. Microbiology (in press)
6. Burger G, Strauss J, Scazzochhio C, Lang F (1991) nirA, the pathway specific regulatory gene of nitrate assimilation in Aspergillus nidulans, encodes a putative GAL4-type zinc finger protein and contains four introns in highly conserved regions. Mol Cell Biol 11:5746-5755
7. Caddick MX, Peters D, Platt A (1994) Nitrogen regulation in fungi. Ant van Leeuwenhoek 65:169-177
8. Campbell WH, Kinghorn JR (1990) Functional domains of assimilatory nitrate reductase and nitrite reductase. Trends Biochem Sci 15:315-319
9. Chang P-K, Cary JW, Bhatnagar D, Cleveland TE, Bennett JW, Linz JE, Woloshuk CP, Payne GA (1993) Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis. Appl Environ Microbiol 59:3273-3279
10. Chang P-K, Bhatnagar D, Cleveland TE, Bennett JW (1995a) Sequence variability in homologs of the aflatoxin pathway gene aflR distinguishes species in Aspergillus Section Flavi. Appl Environ Microbiol 61:40-43
11. Chang P-K, Ehrlich KC, Yu J, Bhatnagar D, Cleveland TE (1995b) Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis. Appl Environ Microbiol 61:2372-2377
12. Chiang T-Y, Marzluf GA (1994) DNA recognition by the NIT2 nitrogen regulatory protein: importance of the number, spacing, and orientation of GATA core elements and their flanking sequences upon NIT2 binding. Biochemistry 33:576-582
13. Cove, DJ (1979) Genetic studies of nitrate assimilation in Aspergillus nidulans. Biol Rev 54:291-327
14. Crawford N, Smith M, Bellissimo D, Davis R (1988) Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains. Proc Natl Acad Sci USA 85:5006-5010
15. Diolez A, Langin T, Gerlinger C, Brygoo Y, Daboussi MJ (1993) The niaD gene of Fusarium oxysporum: isolation, sequence and development of a homologous transformation system. Gene 131:61-67
16. Exley GE, Colandene JD, Garrett RH (1993) Molecular cloning, characterization, and nucleotide sequence of nit-6, the structural gene for nitrate reductase in Neurospora crassa. J Bacteriol 175:2379-2392
17. Feng B, Friedlin E, Marzluf GA (1995) Nuclear DNA-binding proteins which recognize the intergenic control region of penicillin biosynthetic genes. Curr Genet 27:351-358
18. Fu Y-H, Marzluf GA (1988) Metabolic control and autoregulation of nit-3, the nitrate reductase structural gene of Neurospora crassa. J Bacteriol 170:657-661
19. Fu Y-H, Marzluf GA (1990) nit-2, the major positive-acting nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. Proc Natl Acad Sci USA 87:5331-5335
20. Fu Y-H, Feng B, Evans S, Marzluf GA (1995) Sequence-specific DNA binding by NIT4, the pathway specific regulatory protein that mediates nitrate induction in Neurospora. Mol Microbiol 15:935-942
21. Garde J, Kinghorn JR, Tomsett AB (1995) Site-directed mutagenesis of nitrate reductase from Aspergillus nidulans: identification of some essential and some nonessential amino acids among conserved residues. J Biol Chem 270:6644-6650
22. Gish W, States DJ (1993) Identification of protein coding regions by database similarity search. Nature Genet 3:266-272
23. Guiard B, Lederer F (1979) The cytochrome b5 fold: structure of a novel protein superfamily. J Mol Biol 135:639-650
24. Haas H, Marzluf GA (1995) NRE, the major nitrogen regulatory protein of Penicillium chrysogenum, binds specifically to elements in the intergenic promoter regions of nitrate assimilation and penicillium biosynthetic gene clusters. Curr Genet 28:177-183
25. Haas H, Bauer B, Redl B, Stoffler G, Marzluf GA (1995) Molecular cloning and analysis of nre, the major nitrogen regulatory gene of Penicillium chrysogenum. Curr Genet 27:150-158
26. Hackett CS, Novoa WB, Ozols J, Strittmatter P (1986) Identification of the essential cysteine residue of NADH-cytochrome b5 reductase. J Biol Chem 261:9854-9857
27. Horng JS, Chang P-K, Pestka JJ, Linz JE (1990) Development of a homologous transformation system for Aspergillus parasiticus with the gene encoding nitrate reductase. Mol Gen Genet 224:294-296
28. Jarai G, Truong H-N, Daniel-Vedele F, Marzluf GA (1992) NIT2, the nitrogen regulatory protein of Neurospora crassa, binds upstream of nia, the tomato nitrate reductase gene, in vitro. Curr Genet 21:37-41
29. Johnstone IL, MacCabe PC, Greaves P, Gurr SJ, Cole GE, Brow MAD, Unkles SE, Clutterbuck AJ, Kinghorn JR, Innis MA (1990) Isolation and characterization of the crnA-niiA-niaD gene cluster for nitrate assimilation in Aspergillus nidulans. Gene 90:182-192
30. Kachholz T, Demain AL (1983) Nitrate repression of averufin and aflatoxin biosynthesis. J Nat Products 46:499-506
31. Kitamoto N, Kimura T, Kito Y, Ohmiya K, Tsukagoshi N (1995) The nitrate reductase gene from a shoyu koji mold, Aspergillus oryzae KBM616. Biosci Biotech Biochem 59:1795-1797
32. Klich MA, Pitt JI (1988) Differentiation of Aspergillus flavus from Aspergillus parasiticus and other closely related species. Trans Br Mycol Soc 91:99-108
33. Kudla B, Caddick M, Langdon T, Martinez-Rossi NM, Bennett CF, Bibley S, Davis RW, Arst HN Jr (1990) The regulatory gene are A mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger. EMBO J 9:1355-1364
34. Marzluf GA (1981) Regulation of nitrogen metabolism and gene expression in fungi. Microbiol Rev 45:437-461
35. Marzluf GA (1993) Regulation of sulfur and nitrogen metabolism in filamentous fungi. Annu Rev Microbiol 47:31-55
36. Merika M, Orkin S (1993) DNA-binding specificity of GATA family transcription factors. Mol Cell Biol 13:3999-4010
37. Nason A, Evans H (1952) Triphosphopyridine nucleotide-nitrate reductase in Neurospora. J Biol Chem 202:655-673
38. Okamoto PM, Fu Y-H, Marzluf GA (1991) nit-3, the structural gene of nitrate reductase in Neurospora crassa: nucleotide sequence and regulation of mRNA synthesis and turnover. Mol Gen Genet 227:213-223
39. Pieterse CMJ, van't Klooster J, Crardy CM, van den Gerg-Velthus, Covers F (1995) NiaA, the structural nitrate reductase gene of Phytophthora infestans: isolation, characterization and expression analysis in Aspergillus nidulans. Curr Genet 27:359-366
40. Prodouz KN, Garrett GH (1981) Neurospora crassa NAD(P)H-nitrite reductase: studies on its composition and structure. J Biol Chem 256:9711-9717
41. Punt PJ, Strauss J, Smit R, Kinghorn JR, van den Hondel CAMJJ, Scazzocchio C (1995) The intergenic region between the divergently transcribed niiA and niaD genes of Aspergillus nidulans contains multiple NirA-binding sites which act bidirectionally. Mol Cell Biol 10:5688-5699
42. Samson RA, Pitt JI (1985) Advances in Penicillium and Aspergillus systemics. Plenum Press, New York
43. Scazzocchio C (1992) Control of gene expression in the catabolic pathways of Aspergillus nidulans: a personal and biased account. In Bennett JW, Klich MA (eds) Aspergillus - biology and industrial applications. Butterworth-Heinemann, Stoneham, Massachusetts, pp 43-68
44. Staudt LM, Singh H, Sen R, Writh T, Sharp PA, Baltimore D (1986) A lymphoid-specific protein binding to the octamer motif of immunoglobin genes. Nature 323:640-643
45. Unkles SE (1992) Gene organization in industrial filamentous fungi. In Kinghorn JR, Turner G (eds) Applied molecular genetics of filamentous fungi.Academic and Professional, New York, pp 28-53
46. Unkles SE, Hawker KL, Grieve C, Campbell EI, Montague P, Kinghorn JR (1991) crnA encodes a nitrate transporter in Aspergillus nidulans. Proc Natl Acad Sci USA 88:204-208
47. Unkles SE, Campbell EI, Punt PJ, Hawker KL, Contreras R, Kawkins AR, Van den Hondel CAMJJ, Kinghorn JR (1992) The Aspergillus niger niaD gene encoding nitrate reductase: upstream nucleotide and amino acid sequence comparisons. Gene 111:149-155
48. Whitehead M P, Shieh MT, Cleveland TE, Cary JW, Dean RA (1995) Isolation and characterization of polygalacturonase genes (pecA and pecB) from Aspergillus flavus. Appl Environ Microbiol 61:3316-3322
49. Wierenga RK, De Maeyer MC, Hol WGJ (1985) Interaction of pyrophosphale moieties with α-helixes in dinucleotide-binding proteins. Biochemistry 24:1346-1357
50. Williams RSB, Davis MA, Hewlett B (1994) Nitrate reductase of the ascomycetous fungus Leptosphaeria maculans: gene sequence and chromosomal location. Mol Gen Genet 244:1-8
51. Williams RSB, Davis MA, Hewlett B (1995) The nitrate and nitrite reductase-containing genes of Leptosphaeria maculans are closely linked and transcribed in the same direction. Gene 158:153-154
52. Yuan G-F, Fu Y-H, Marzluf GA (1991) nit-4, a pathway-specific regulatory gene of Neurospora crassa, encodes a protein with a putative binuclear zinc DNA-binding domain. Mol Cell Biol 11:5735-5745