Relationship between secondary metabolism and fungal development

Microbiology and Molecular Biology Reviews

Volumn 66, Issue 3, 2002, Pages 447-459

  Calvo, Ana M ^a   Wilson, Richard A ^a   Bok, Jin Woo ^a   Keller, Nancy P ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN; CYCLOPIAZONIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; MYCOTOXIN; POLYAMINE; STERIGMATOCYSTIN; TRICHOTHECENE;

ANIMAL CELL; ARTICLE; ASPERGILLUS NIDULANS; CATALYSIS; CELL DIFFERENTIATION; COLONY FORMATION; ENZYME ACTIVE SITE; FUNGAL METABOLISM; FUNGUS GROWTH; GROWTH REGULATION; NONHUMAN; POLYMERIZATION; SIGNAL TRANSDUCTION; SPOROGENESIS;

AFLATOXINS; ASPERGILLUS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FUNGAL PROTEINS; FUNGI; HYDROGEN-ION CONCENTRATION; MYCOTOXINS; SIGNAL TRANSDUCTION; SPORES, FUNGAL; STERIGMATOCYSTIN; TRANSCRIPTION FACTORS;

ACTINOBACTERIA (CLASS); ANIMALIA; ASPERGILLUS; EMERICELLA NIDULANS; FUNGI;

EID: 0036712096     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/MMBR.66.3.447-459.2002     Document Type: Article

References (135)

1. Regulation of aflatoxin biosynthesis: Characterization of glucose as an apparent inducer of aflatoxin production
2. brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans
3. brlA requires both zinc fingers to induce development
4. Isolation of a gene required for programmed initiation of development by Aspergillus nidulans
5. Coordinate control of secondary metabolite production and asexual sporulation in Aspergillus nidulans
6. Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP
7. The cyclin family of budding yeasts: Abundant use of a good idea
8. ATTS, a new and conserved DNA binding domain
9. A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation in Schizosaccharomyces pombe
10. Loss of norsolorinic acid and aflatoxin production by a mutant of Aspergillus parasiticus
11. Sclerotial and low aflatoxigenic morphological variants from haploid and diploid Aspergillus parasiticus
12. The aflatoxigenic Aspergillus
13. Influence of trace elements and nitrogen source on versicolorin production by a mutant strain of Aspergillus parasiticus
14. Brevianamides A and B are formed only after conidiation has begun in solid cultures of Penicillium brevicompactum
15. Bidirectional gene transfer between Aspergillus fumigatus and Aspergillus nidulans
16. Isolation and physical characterization of three essential conidiation genes from Aspergillus nidulans
17. Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans
18. Ability of various carbon sources to induce and support aflatoxin biosynthesis by Aspergillus parasiticus
19. Effects of initial pH on aflatoxin production
20. Intermediary metabolism and antibiotic synthesis
21. Seed lipoxygenase products modulate Aspergillus mycotoxin biosynthesis
22. Genetic connection between fatty acid metabolism and sporulation in Aspergillus nidulans
23. Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp
24. Generation of aflR disruption mutants of Aspergillus parasiticus
25. Isolation of a sexual sporulation hormone from Aspergillus nidulans
26. An endogenous inducer of sexual development in Aspergillus nidulans
27. Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis
28. Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis
29. Characterization of the Aspergillus parasiticus major nitrogen regulatory gene, areA
30. A mutational analysis of conidial development in Aspergillus nidulans
31. Aflatoxin and sclerotial production by Aspergillus flavus: Influence of pH
32. The involvement of cell-to-cell signals in the development of a bacterial biofilm
33. Lipoperoxidase activity of Pityrosporum: Characterisation of by-products and possible role in pityriasis versicolor
34. The natural functions of secondary metabolites
35. Evidence implicating the lipoxygenase pathway in providing resistance to soybean against Aspergillus flavus
36. Genetic and morphological properties of undifferentiated and invasive variants of Aspergillus nidulans
37. Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4
38. Characterization of the promoter for the gene encoding the aflatoxin biosynthetic pathway regulatory protein AFLR
39. On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction
40. pH regulation is a major determinant in expression of a fungal penicillin biosynthetic gene
41. Culture conditions control expression of the genes for aflatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and A. nidulans
42. cAMP and ras signaling independently control spore germination in the filamentous fungus Aspergillus nidulans
43. Overexpression of aflR leads to upregulation of pathway gene expression and increased aflatoxin production in Aspergillus flavus
44. Distinct roles for two G protein α subunits in fungal virulence, morphology, and reproduction revealed by targeted gene disruption
45. Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth
46. cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis
47. The plant growth regulator methyl jasmonate inhibits aflatoxin production by Aspergillus flavus
48. Correlation between the regulation of sterigmatocystin biosynthesis and asexual and sexual sporulation in Emericella nidulans
49. Relationship between aflatoxin biosynthesis and sporulation in Aspergillus parasiticus
50. The sporulation of Penicillium notatum westling in submerged liquid cultures
51. RcoA has pleiotropic effects on Aspergillus nidulans cellular development
52. Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G-alpha protein-dependent signaling pathway
53. Towards an understanding of gene switching in Streptomyces, the basis of sporulation and antibiotic production
54. Cloning an Aspergillus nidulans developmental gene by transformation
55. Nitrate repression of averufin and aflatoxin biosynthesis
56. Isolation and characterization of morphological variants of Aspergillus parasiticus
57. Characterization of experimentally induced, nonaflatoxigenic variant strains of Aspergillus parasiticus
58. Targeted disruption of a fungal G-protein beta subunit gene results in increased vegetative growth but reduced virulence
59. Targeted disruption of a melanin biosynthesis gene affects conidial development and UV tolerance in the Japanese pear pathotype of Alternaria alternata
60. Metabolic pathway gene clusters in filamentous fungi
61. pH regulation of sterigmatocystin and aflatoxin biosynthesis in Aspergillus spp
62. Signaling via cAMP in fungi: Interconnections with mitogen-activated protein kinase pathways
63. Pleiotropic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2)
64. FluG and FlbA function interdependently to initiate conidiophore development in Aspergillus nidulans through brlA beta activation
65. The Aspergillus nidulans fluG gene is required for production of an extracellular developmental signal
66. Overexpression of flbA, an early regulator of Aspergillus asexual sporulation, leads to activation of brlA and premature initiation of development
67. Signal transduction cascade regulating fungal development and virulence
68. Virulence, temperature optima, and competitive abilities of isolines of races T and O of Bipolaris maydis
69. A kinase-cyclin pair in the RNA polymerase II holoenzyme
70. The Aspergillus nidulans penicillin-biosynthesis gene aat (penDE) is controlled by a CCAAT-containing DNA element
71. Regulation of aflR and its product, AflR, associated with aflatoxin biosynthesis
72. Biosynthesis of aflatoxin-the role of nutritional factors
73. The evolutionary role of secondary metabolites
74. A quantitative survey of conidiation mutants in Aspergillus nidulans
75. Structure and synthesis of sporogenic psi factors from Aspergillus nidulans
76. Characterization of aflJ, a gene required for conversion of pathway intermediates to aflatoxin
77. Ultrastructural analysis of conidiophore development in the fungus Aspergillus nidulans using freeze-substitution
78. Isolation and characterisation of the acetyl-CoA carboxylase gene from Aspergillus nidulans
79. Crosstalk between the Ras2p-controlled mitogen-activated protein kinase and cAMP pathways during invasive growth of Saccharomyces cerevisiae
80. The ancient regulatory-protein family of WD-repeat proteins
81. Nitrate induces enzymes of the mannitol cycle and suppresses versicolorin synthesis in Aspergillus parasiticus
82. Conidiophore and spore development in Aspergillus nidulans
83. The hapC gene of Aspergillus nidulans is involved in the expression of CCAAT-containing promoters
84. Sporulation in Geotrichum candidum
85. Role of lipoperoxidation in aflatoxin production
86. Aflatoxin in maize
87. Genetics and physiology of aflatoxin biosynthesis
88. Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus
89. The relationship between conidiation and alkaloid production in saprophytic strains of Claviceps purpurea
90. A polyketide synthase gene required for biosynthesis of fumonisin mycotoxins in Gibberella fujikuroi mating population A
91. The effects of some polyamine biosynthetic inhibitors on growth and morphology of phytopathogenic fungi
92. Development of Aspergillus parasiticus and formation of aflatoxin B1 under the influence of conidiogenesis affecting compounds
93. The Aspergillus nidulans sfaD gene encodes a G protein β subunit that is required for normal growth and repression of sporulation
94. Polyamines, DNA methylation, and fungal differentiation
95. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene
96. Effect of butyrolactone I on the producing fungus, Aspergillus terreus
97. Conidiogenesis and secondary metabolism in Penicillium urticae
98. Regulation of fumonisin BI biosynthesis and conidiation in Fusarium verticillioides by a cyclin-like (C-type) gene, FCC1
99. Genetic involvement of cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans
100. The WD repeat: A common architecture for diverse functions
101. Developmental decisions in Aspergillus nidulans are modulated by Ras activity
102. AnCF, the CCAAT binding complex of Aspergillus nidulans, contains products of the hapB, hapC, and hapE genes and is required for activation by the pathway-specific regulatory gene amdR
103. On the evolution of functional secondary metabolites (natural products)
104. Characterization of a Penicillium chrysogenum gene encoding a PacC transcription factor and its binding sites in the divergent pcbAB-pcbC promoter of the penicillin biosynthetic cluster
105. G-protein signalling mediates differential production of toxic secondary metabolites
106. The Colletotrichum lagenarium MAP kinase gene CMKI regulates diverse aspects of fungal pathogenesis
107. High-frequency conversion of a "fluffy" developmental phenotype in Aspergillus spp. by 5-azacytidine treatment: Evidence for involvement of a single nuclear gene
108. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH
109. Evolution of a fungal regulatory gene family: The Zn(II)2Cys6 binuclear cluster DNA binding motif
110. Molecular biology of aflatoxin biosynthesis
111. The developmentally regulated alb1 gene of Aspergillus fumigatus: Its role in modulation of conidial morphology and virulence
112. The WD-40 repeats
113. Genetic requirements for initiating asexual development in Aspergillus nidulans
114. Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in Aspergillus nidulans and a member of the "streetwise" GATA family of transcription factors
115. Regulation of sexual reproduction in Gibberella zeae (Fusarium roseum 'Graminearum') by F-2 (zearalenone)
116. Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesis
117. Effects of volatile aldehydes from Aspergillus-resistant varieties of corn on Aspergillus parasiticus growth and aflatoxin biosynthesis
118. Characterization of rco-1 of Neurospora crassa, a pleiotropic gene affecting growth and development that encodes a homolog of Tup1 of Saccharomyces cerevisiae
119. Mutational activation of a G1 causes uncontrolled proliferation of aerial hyphae and increased sensitivity to heat and oxidative stress in Neurospora crassa
120. Cloning of a sugar utilization gene cluster in Aspergillus parasiticus
121. Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus
122. Extragenic suppressors of loss-of-function mutations in the Aspergillus FlbA regulator of G-protein signaling domain protein
123. The Aspergillus FlbA RGS domain protein antagonizes G protein signaling to block proliferation and allow development
124. Review of compounds affecting the biosynthesis or bio-regulation of aflatoxins
125. Identification and effects of maize silk volatiles on cultures of Aspergillus nidulans