Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains

Biochemistry

Volumn 49, Issue 33, 2010, Pages 7050-7059

  Pierce, Brian G ^a,b   Haidar, Jaafar N ^c   Yu, Yong ^b,c   Weng, Zhiping ^a,b,c  

^a BOSTON UNIVERSITY   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOOPERATIVITY; ASSOCIATION RATES; BINDING AFFINITIES; BINDING KINETICS; COMPLEMENTARITY-DETERMINING REGIONS; COMPLEX NATURE; COOPERATIVE INTERACTIONS; COOPERATIVITY; DISSOCIATION RATES; FUTURE DESIGNS; IN-VITRO; IN-VIVO; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIPLE MUTATIONS; NON-ADDITIVE; POINT MUTATIONS; PROTEIN DESIGN; PROTEIN-PROTEIN INTERFACE; SIDE CHAINS; STRUCTURAL MODELING; STRUCTURAL RESPONSE; STRUCTURE-BASED DESIGNS; T CELL RECEPTOR; T-CELL RECEPTORS; TWO SOURCES; VIRAL PEPTIDES; WILD TYPES;

AMINO ACIDS; CELL MEMBRANES; DESIGN; DISSOCIATION; ORGANIC ACIDS; PEPTIDES;

BINDING ENERGY;

MUTANT PROTEIN; T LYMPHOCYTE RECEPTOR; HLA A2 ANTIGEN; LEUCYL-LEUCYL-PHENYLALANYL-GLYCYL-TYROSYL-PROLYL-VALYL-TYROSYL-VALINE; LYMPHOCYTE ANTIGEN RECEPTOR; OLIGOPEPTIDE; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; DISSOCIATION CONSTANT; GENE MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; CHEMICAL STRUCTURE; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; KINETICS; METABOLISM; POINT MUTATION; PROTEIN CONFORMATION;

ESCHERICHIA COLI; GENE EXPRESSION; HLA-A2 ANTIGEN; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; KINETICS; MODELS, MOLECULAR; OLIGOPEPTIDES; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 77955687387     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901969a     Document Type: Article

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