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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5217-5220

X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors

(7) Kuglstatter, Andreas a,b Ghate, Manjiri a Tsing, Stan a Villaseñor, Armando G a Shaw, David a,c Barnett, Jim W a Browner, Michelle F a,d

a ROCHE BIOSCIENCE (United States)

b HOFFMANN LA ROCHE INC (United States)

c GENENTECH INC (United States)

d F HOFFMANN LA ROCHE LTD (Switzerland)

Author keywords

BIRB796; DFG out; JNK2; Kinase inhibitor; p38; Protein crystallography; Protein kinase; Structure based drug design; X ray crystal structure

Indexed keywords

DORAMAPIMOD; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7;

ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MITOGEN-ACTIVATED PROTEIN KINASE 9; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRAZOLES;

EID: 77955664248 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.06.157 Document Type: Article

Times cited : (31)

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