The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38α for High Throughput Screening Binding Assay

Chemical Biology and Drug Design

Volumn 74, Issue 6, 2009, Pages 547-559

  Tecle, Haile ^a   Feru, Frederic ^a   Liu, Hu ^a   Kuhn, Cyrille ^a   Rennie, Glen ^a   Morris, Mark ^a   Shao, Jiangxing ^a   Cheng, Alan C ^a   Gikunju, Diana ^a   Miret, Juan ^a   Coli, Rocco ^a   Xi, Simon ^a   Clugston, Susan L ^a   Low, Simon ^a   Kazmirski, Steven ^a   Ding, Yuan Hua ^a   Cao, Qing ^a   Johnson, Theresa L ^a   Deshmukh, Gayatri D ^a   Dinitto, Jonathan P ^a   Wu, Joe C ^a   English, Jessie M ^a   more..

^a PFIZER INC   (United States)

Author keywords

DFG out inhibitors; Fluorescence probes; HTS; Non classical kinase inhibitors; P38 inhibitors

Indexed keywords

1 [1(4(AMINOMETHYL)PHENYL)3 TERT BUTYL 1H PYRAZOL 5 YL] 3(NAPHTHALEN 1 YL)UREA; 1[1(4((2 AMINOACETAMIDO)METHYL)PHENYL)3 TERT BUTYL 1H PYRAZOL 5 YL]3 PHENYLUREA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG DESIGN; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; PRIORITY JOURNAL;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FLUORESCENT DYES; HIGH-THROUGHPUT SCREENING ASSAYS; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASE 14; NAPHTHALENES; PROTEIN KINASE INHIBITORS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70350552210     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00884.x     Document Type: Article

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