High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38α

Journal of the American Chemical Society

Volumn 131, Issue 51, 2009, Pages 18478-18488

  Simard, Jeffrey R ^a   Grütter, Christian ^a   Pawar, Vijaykumar ^a   Aust, Beate ^a   Wolf, Alexander ^a   Rabiller, Matthias ^a   Wulfert, Sabine ^a   Robubi, Armin ^a   Klüter, Sabine ^a   Ottmann, Christian ^a   Rauh, Daniel ^a  

^a CHEMICAL GENOMICS CENTRE OF THE MAX PLANCK SOCIETY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAY SYSTEM; BINDING MODES; CHEMICAL BIOLOGY; HIGH-THROUGHPUT SCREENING; KINASE ACTIVITY; KINASE FUNCTION; KINASE INHIBITORS; MAP KINASE; MEDICINAL CHEMISTRY; PHOSPHORYLATION REACTIONS; PROTEIN X-RAY CRYSTALLOGRAPHY; REGULATORY PROCESS; SMALL MOLECULES; SMALL ORGANIC MOLECULES; STRUCTURAL FEATURE; STRUCTURAL TRANSITIONS;

ASSAYS; BINDING ENERGY; BIOLOGY; IMAGE SENSORS; MINERALOGY; MOLECULES; PHOSPHORYLATION; PROTEINS; SELF ASSEMBLY; X RAY CRYSTALLOGRAPHY;

CONFORMATIONS;

MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR;

ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME STABILITY; ENZYME STRUCTURE; HIGH THROUGHPUT SCREENING; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME STABILITY; HUMANS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 14; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 73249153398     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja907795q     Document Type: Article

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