An INSIG2 Polymorphism Affects Glucose Homeostasis in Sardinian Obese Children and Adolescents

Annals of Human Genetics

Volumn 74, Issue 5, 2010, Pages 381-386

  Zavattari, Patrizia ^a   Loche, Alberto ^a   Civolani, Patrizia ^a   Pilia, Sabrina ^a   Moi, Loredana ^a   Casini, Maria Rosaria ^a   Minerba, Luigi ^b   Loche, Sandro ^a  

^a Osp Regionale per le Microcitemie   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Genetic association analysis; Glycaemia; HOMA; IFG; IGT; Insulinemia

Indexed keywords

GLUCOSE; INSULIN; MEMBRANE PROTEIN; PROTEIN INSIG 2; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; INSIG2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENOTYPE; GLUCOSE HOMEOSTASIS; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; COMPLICATION; GENETICS; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; ITALY; METABOLISM;

ADOLESCENT; BLOOD GLUCOSE; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ITALY; MALE; MEMBRANE PROTEINS; OBESITY;

EID: 77955641860     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2010.00590.x     Document Type: Article

References (27)

1. Type 2 diabetes in children and adolescents. Diabetes Care 2000, 23:381-389. American Diabetes Association
2. Andreasen C H, Mogensen M S, Borch-Johnsen K, Sandbaek A, Lauritzen T, Sørensen T I, Hansen L, Almind K, Jørgensen T, Pedersen O, Hansen T. Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS ONE. 2008, 3:e2872.
3. Bressler J, Fornage M, Hanis C L, Kao W H, Lewis C E, McPherson R, Dent R, Mosley T H, Pennacchio L A, Boerwinkle E. The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts. BMC Med Genet 2009, 10:56.
4. Cacciari E, Milani S, Balsamo A, Spada E, Bona G, Cavallo L, Cerutti F, Gargantini L, Greggio N, Tonini G, Cicognani A. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J Endocrinol Invest 2006, 29:581-593.
5. Cambuli V M, Incani M, Pilia S, Congiu T, Cavallo M G, Cossu E, Sentinelli F, Mariotti S, Loche S, Baroni M G. Oral glucose tolerance test in Italian overweight/obese children and adolescents results in a very high prevalence of impaired fasting glycaemia, but not of diabetes. Diabetes Metab Res Rev 2009, 25:528-534.
6. Cavalli-Sforza L L, Piazza A, Menozzi P, Mountain J. Reconstruction of human evolution: bringing together genetic, archaeological, and linguistic data. Proc Natl Acad Sci USA 1988, 85:6002-6006.
7. Dina C. New insights into the genetics of body weight. Curr Opin Clin Nutr Metab Care 2008, 11:378-384.
8. Heid I M, Huth C, Loos R J, Kronenberg F, Adamkova V, Anand S S, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper J A, Corella D, Dina C, Engert J C, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele R A, Hinney A, Hoehe M R, Hu F B, Hubacek J A, Humphries S E, Hunt S C, Illig T, Järvelin M R, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange L A, Langer B, Li S, Luchner A, Lyon H N, Meyre D, Mohlke K L, Mooser V, Nebel A, Nguyen T T, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran K S, Wareham N J, Waterworth D, Yusuf S, Lindgren C, McCarthy M I, Lange C, Hirschhorn J N, Laird N, Wichmann H E. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?. PLoS Genet 2009, 5:e1000694.
9. Herbert A, Gerry N P, McQueen M B, Heid I M, Pfeufer A, Illig T, Wichmann H E, Meitinger T, Hunter D, Hu F B, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn J N, Laird N M, Lenburg M E, Lange C, Christman M F. A common genetic variant is associated with adult and childhood obesity. Science 2006, 312:279-283.
10. Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y. INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. J Hum Genet 2008, 53:857-862.
11. Janowski B A. The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP. Proc Natl Acad Sci U S A 2002, 99:12675-12680.
12. Krapivner S, Chernogubova E, Ericsson M, Ahlbeck-Glader C, Hamsten A, van 't Hooft F M. Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration. Diabetologia 2007, 50:94-102.
13. Krapivner S, Popov S, Chernogubova E, Hellénius M L, Fisher R M, Hamsten A, van't Hooft F M. Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation. J Clin Endocrinol Metab 2008, 93:1995-2001.
14. Kuzuya M, Ando F, Iguchi A, Shimokata H. No association between rs7566605 variant and being overweight in Japanese. Obesity (Silver Spring) 2007, 15:2531-2534.
15. Loos R J F. Recent progress in the genetics of common obesity. Br J Clin Pharmacol 2009, 68:811-829.
16. Lyon H N, Emilsson V, Hinney A, Heid I M, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters G B, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen T T, Scherag A, Pfeufer A, Meitinger T, Brönner G, Rief W, Soto-Quiros M E, Avila L, Klanderman B, Raby B A, Silverman E K, Weiss S T, Laird N, Ding X, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler J L, Cooper R S, Fox C S, O'Donnell C J, Vollmert C, Celedón J C, Wichmann H E, Hebebrand J, Stefansson K, Lange C, Hirschhorn J N. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet 2007, 3:627-633.
17. Lustig R H. Childhood obesity: behavioral aberration or biochemical drive? Reinterpreting the First Law of Thermodynamics. Nat Clin Pract Endocrinol Metab 2006, 2:447-458.
18. Niswender K D, Schwartz M W. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signalling capabilities. Front Neuroendocrinol 2003, 24:1-10.
19. O'Rahilly S. Human genetics illuminates the paths to metabolic disease. Nature 2009, 462:307-314.
20. Scuteri A, Sanna S, Chen W M, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orrú M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret G B, Fink A A, Weder A B, Cooper R S, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis G R. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007, 3:e115.
21. Songini M, Casu A. Epidemiology of childhood diabetes. Acta Biomed 2005, 76:19-25.
22. Talbert M E, Langefeld C D, Ziegler J T, Haffner S M, Norris J M, Bowden D W. INSIG2 SNPs Associated With Obesity and Glucose Homeostasis Traits in Hispanics: The IRAS Family Study. Obesity (Silver Spring) 2009, 17:1554-1562.
23. Tabara Y, Kawamoto R, Osawa H, Nakura J, Makino H, Miki T, Kohara K. No Association Between INSIG2 Gene rs7566605 Polymorphism and Being Overweight in Japanese Population. Obesity (Silver Spring) 2008, 16:211-215.
24. Vimaleswaran K S, Franks P W, Brage S, Sardinha L B, Andersen L B, Wareham N J, Ekelund U, Loos R J. Absence of Association Between the INSIG2 Gene Polymorphism (rs7566605) and Obesity in the European Youth Heart Study (EYHS). Obesity (Silver Spring) 2009, 17:1453-1457.
25. Wang HJ, Zhang H, Zhang SW, Pan YP, Ma J. Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents. Biomed Environ Sci 2008, 21:528-536.
26. Wiedmann S, Neureuther K, Stark K, Reinhard W, Kallmünzer B, Baessler A, Fischer M, Linsel-Nitschke P, Erdmann J, Schunkert H, Hengstenberg C. Lack of Association Between a Common Polymorphism Near the INSIG2 Gene and BMI, Myocardial Infarction, and Cardiovascular Risk Factors. Obesity (Silver Spring) 2009, 17:1390-1395.
27. Zhang J, Lin R, Wang F, Lu M, Lin R Y, Wang S Z, Wen H, Jin L, Wang X F. A common polymorphism is associated with body mass index in Uyghur population. Diabetes Res Clin Pract 2008, 81:e11-e13.