Oral glucose tolerance test in Italian overweight/obese children and adolescents results in a very high prevalence of impaired fasting glycaemia, but not of diabetes

Diabetes/Metabolism Research and Reviews

Volumn 25, Issue 6, 2009, Pages 528-534

  Cambuli, Valentina M ^a,b   Incani, Michela ^a   Pilia, Sabrina ^c   Congiu, Tiziana ^a   Cavallo, M Gisella ^b   Cossu, Efisio ^a   Sentinelli, Federica ^a   Mariotti, Stefano ^a   Loche, Sandro ^c   Baroni, Marco G ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Osp Regionale per le Microcitemie   (Italy)

Author keywords

Childhood diabetes; Childhood obesity; Impaired fasting glycaemia (IFG); Oral glucose tolerance test (OGTT)

Indexed keywords

GLUCOSE;

ADOLESCENT; ARTICLE; CHILD; CHILD HEALTH; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HUMAN; HYPERGLYCEMIA; HYPERTENSION; INSULIN RESISTANCE; ITALY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PREVALENCE; PRIORITY JOURNAL;

ADOLESCENT; AGING; BLOOD GLUCOSE; BODY MASS INDEX; CHILD; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; ITALY; LIPIDS; MALE; OBESITY; OVERWEIGHT; PREVALENCE; URIC ACID;

EID: 70350591729     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.980     Document Type: Article

References (31)

1. Wang Y, Lobstein T. Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 2006; 1(1): 11-25.
2. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 2005; 146: 693-700. (Pubitemid 40616257)
3. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000; 321: 405-412. (Pubitemid 30609442)
4. American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care 2000; 23: 381-389.
5. Alberti G, Zimmet P, Shaw J, Bloomgarden Z, Kaufman F, Silink M, for the Consensus Whorkshop Group. Type 2 diabetes in the young: the evolving epidemic. The International Diabetes Federation Consensus Workshop. Diabetes Care 2004; 27(7): 1798-1811. (Pubitemid 38857467)
6. International diabetes federation. Global Guideline for Type 2 Diabetes. Available from http://www.idf.org 2005.
7. Williams DE, Cadwell BL, Cheng YJ, et al. Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000. Pediatrics 2005; 116: 1122-1126.
8. Sinha R, Fisch G, Teague B, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002; 346: 802-810. (Pubitemid 34984653)
9. Gilardini L, Girola A, Morabito F, Invitti C. Fasting glucose is not useful in identifying obese white children with impaired glucose tolerance. J Pediatr 2006; 149(2): 282. (Pubitemid 44144484)
10. Wabitsch M, Hauner H, Hertrampf M, et al. Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany. Int J Obes Relat Metab Disord 2004; 28: 307-313. (Pubitemid 38223514)
11. Invitti C, Guzzaloni G, Gilardini L, Morabito F, Viberti G. Prevalence and concomitants of glucose intolerance in European obese children and adolescents. Diabetes Care 2003; 26: 118-124. (Pubitemid 36929003)
12. Reinehr T. Clinical presentation of type 2 diabetes mellitus in children and adolescents. Int J Obes (Lond) 2005; 29: S105-S110. (Pubitemid 40514885)
13. Casu A, Pascutto C, Bernardinelli L, Songini M, The Sardinian IDDM Epidemiology Study Group. Type 1 diabetes among Sardinian children is increasing. The Sardinian Diabetes register 0-14 years, 1989-1999. Diabetes Care 2004; 27: 1623-1629.
14. Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J, Diabetes Mondiale (DiaMond) Project Group. Incidence of childhood type 1 diabetes worldwide. Diabetes Care 2000; 23(10): 1516-1526. (Pubitemid 30746125)
15. Marras V, Macchis R, Foschini ML, et al. Prevalence of overweight and obesity in primary school children in Southern Sardinia, Italy. Ital J Pediatr 2006; 32: 251-255. (Pubitemid 46155841)
16. Gomez-Diaz R, Aguilar-Salinas CA, Moran-Villota S, et al. Lack of agreement between the revised criteria of impaired fasting glucose and impaired glucose tolerance in children with excess body weight. Diabetes Care 2004; 27: 2229-2233. (Pubitemid 39167190)
17. Cacciari E, Milani S, Balsamo A, et al. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J Endocrinol Invest 2006; 29: 581-593. (Pubitemid 44446267)
18. Tanner JM. Growth and maturation during adolescence. Nutr Rev 1981; 39: 43-55.
19. Sacks DB, Bruns DE, Goldstein DE, Maclaren NK,McDonald JM, Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002; 48: 436-472. (Pubitemid 34174577)
20. Matthews DR, Hosker JP, Rudenski AS. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 1985; 28: 412-419. (Pubitemid 15018832)
21. Reilly JJ, McDowell ZC. Physical activity interventions in the prevention and treatment of paediatric obesity: systematic review and critical appraisal. Proc Nutr Soc 2003; 62: 611-619.
22. Cambuli VM, Musiu MC, Incani M, et al. Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children. J Clin Endocrinol Metab 2008; 93(8): 3051-3057.
23. Reinehr T, Stoffel-Wagner B, Roth CL. Adipocyte fatty acid-binding protein in obese children before and after weight loss. Metabolism 2007; 56: 1735-1741. (Pubitemid 350060942)
24. Nichols GA, Hillier TA, Brown JB. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis. Am J Med 2008; 121(6): 519-524. (Pubitemid 351699262)
25. Abdul-Ghani MA, Tripathy D, Defronzo RA. Contributions of β-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care 2006; 29: 1130-1139. (Pubitemid 44115261)
26. Reinehr T, Schober E, Wiegand S, Thon A, Holl R, DPV-Wiss Study Group. Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification? Arch Dis Child 2006; 91(6): 473-477. (Pubitemid 43836095)
27. Locatelli M, Songini M, Bottazzo GF. IDDM-Sardinia Project: a study model on the etiopathogenesis of insulin-dependent diabetes mellitus and other autoimmune pathologies. Gruppi di studio IDDM-Sardegna. Ann Ist Super Sanita 1999; 35(2): 253-263.
28. Lorini R, Alibrandi A, Vitali L, et al, Pediatric Italian Study Group of Prediabetes. Risk of type 1 diabetes development in children with incidental hyperglycemia: a multicenter Italian study. Diabetes Care 2001; 24(7): 1210-1216.
29. Goran MI, Lane C, Toledo-Corral C, Weigensberg MJ. Persistance of pre-diabetes in overweight and obese hispanic children: association with progressive insulin resistance, poor beta-cell function and increasing visceral fat. Diabetes 2008; 57(11): 3007-3012.
30. Libman IM, Barinas-Mitchell E, Bartucci A, Robertson R, Arslanian S. Reproducibility of the oral glucose tolerance test in overweight children. J Clin Endocrinol Metab 2008; 93(11): 4231-4237. (Pubitemid 352789516)
31. Goran MI, Davis J, Kelly L, et al. Low prevalence of pediatric type 2 diabetes: where's the epidemic? J Pediatr 2008; 152: 753-755. (Pubitemid 351680262)