Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents

Biomedical and Environmental Sciences

Volumn 21, Issue 6, 2008, Pages 528-536

  Wang, Hai Jun ^a,c   Zhang, Heng ^b   Zhang, Shi Wei ^b   Pan, Yong Ping ^d   Ma, Jun ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d Dongcheng School Health Care Institute   (China)

Author keywords

Children and adolescents; INSIG2 gene; Obesity related phenotypes

Indexed keywords

EID: 59849118986     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-3988(09)60013-1     Document Type: Article

References (28)

1. Hill J O, Catenacci V, Wyatt H R (2005). Obesity: overview of an epicemic. Psychiatr Clin North Am 28, 1-23.
2. Herbert A, Gerry N P, McQueen M B, et al. (2006). A common genetic variant is associated with adult and childhood obesity. Science 312(5771), 279-283.
3. Rankinen T, Zuberi A, Chagnon Y C, et al. (2006). The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14(4), 529-644.
4. Dina C, Meyre D, Samson C, et al. (2007). Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315(5809), 187.
5. Loos R J, Barroso I, O'rahilly S, et al. (2007). Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315(5809), 187.
6. Hall D H, Rahman T, Avery P J, et al. (2006). INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families. BMC Med Genet 7, 83.
7. Feng Y, Dong H, Xiang Q, et al. (2007). Lack of association between rs7566605 and obesity in a Chinese population. Hum Genet 120(5), 743-745.
8. Kumar J, Sunkishala R R, Karthikeyan G, et al. (2007). The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population. Clin Genet 71(5), 415-418.
9. Smith A J, Cooper J A, Li L K, et al. (2007). INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects. Int J Obes (Land) 31(11), 1753-1755.
10. Pollex R L, Ban M R, Young T K, et al. (2007). Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample. BMC Med Genet 8, 80.
11. Kuzuya M, Ando F, Iguchi A, et al. (2007). No association between rs7566605 variant and being overweight in Japanese. Obesity (Silver Spring) 15(11), 2531-2534.
12. Tabara Y, Kawamoto R, Osawa H, et al. (2008). No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population. Obesity (Silver Spring) 16(1), 211-215.
13. Ciullo M, Nutile T, Dalmasso C, et al. (2008). Identification and replication of a novel obesity locus on chromosome Iq24 in isolated populations of Cilento. Diabetes 57(3), 783-790.
14. Boes E, Kollerits B, Heid I M, et al. (2008). INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism. Obesity (Silver Spring) 16(4), 827-833.
15. Krapivner S, Popov S, Chernogubova E, et al. (2008). Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation. J Clin Endocrinol Metab 93(5), 1995-2001.
16. Yang L, Wu Y, Li H, et al. (2008). Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation. Eur J Hum Genet 16(6), 759-761.
17. Rosskopf D, Bornhorst A, Rimmbach C, et al. (2007). Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315(5809), 187.
18. Lyon H N, Emilsson V, Hinney A, et al. (2007). The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet 3(4), e61.
19. Zhang J, Lin R, Wang F, et al. (2008). A common polymorphism is associated with body mass index in Uyghur population. Diabetes Res Clin Pract [Epub ahead of print]
20. Hotta K, Nakamura M, Nakata Y, et al. (2008). INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. J Hum Genet [Epub ahead of print]
21. Wang H J, Ma J, Yin Z D, et al. (2007). Study on the Relationship Between Obesity and Metabolic Syndrome in Adolescents. Chin J Sch Health 28(10), 878-882. (In Chinese)
22. Ma J, Zhang S W, Wu S X, et al. (2008). Prevalence of metabolic syndrome among children with different nutritional status in Beijing]. Chin J Sch Health 29(2), 103-105. (In Chinese)
23. Group of China Obesity Task Force (2004). Body mass index reference norm for screening overweight and obesity in Chinese children and adolescents. Chin J Epidemiol 25(2), 97-102. (In Chinese)
24. Lohmueller K E, Pearce C L, Pike M, et al. (2003). Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Gene 33(2), 177-182.
25. Yabe D, Brown M S, Goldstein J L (2002). Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA 99(20), 12753-12758.
26. Takaishi K, Duplomb L, Wang M Y, et al. (2004). Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats. Proc Natl Acad Sci USA 101(18), 7106-11.
27. Engelking L J, Liang G, Hammer R E, et al. (2005). Schoenheimer effect explained-feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 115(9), 2489-2498.
28. Oki K, Yamane K, Kamei N, et al. (2008). The single nucleotide polymorphism upstream of insulin-induced gene 2 (INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women. Br J Nutr [Epub ahead of print]