Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2558-2569

  Senthilkumar, Palaniappan ^a   Dinakaran, Murugesan ^a   Banerjee, Debjani ^a   Devakaram, Ruth Vandana ^a   Yogeeswari, Perumal ^a   China, Arnab ^b   Nagaraja, Valakunja ^b   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

8 Methoxyquinolone carboxylic acids; Antimycobacterial activity; Antitubercular activity

Indexed keywords

1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 7 [4 (2 FUROYL)PIPERAZIN 1 YL] 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 7 [4 (2 FUROYL)PIPERAZIN 1 YL] 8 METHOXY 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 5 NITRO 7 [4 (PIPERIDIN 1 YL)PIPERIDIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 5 NITRO 7 THIOMORPHOLINOQUINOLINE 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 7 (4 METHYL 3 PHENYLPIPERAZIN 1 YL) 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 7 (4 METHYL 3 PHENYLPIPERAZIN 1 YL) 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 7 [4 (PIPERIDIN 1 YL)PIPERIDIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 7 THIOMORPHOLINOQUINOLINE 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 7 (1,4 DIOXA 8 AZASPIRO[4.5]DEC 8 YL) 6 FLUORO 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 7 (2,6 DIMETHYLMORPHOLINO) 6 FLUORO 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 7 (2,6 DIMETHYLMORPHOLINO) 6 FLUORO 8 METHOXY 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 7 [4 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 2 OYL)](PIPERAZIN 1 YL) 6 FLUORO 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 1,4 DIHYDRO 7 [4 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 2 OYL)](PIPERAZIN 1 YL) 6 FLUORO 8 METHOXY 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1,2,3,4 TETRAFLUOROBENZENE; 7 [1 (4 METHOXYBENZYL) 3,4,5,6,7,8 HEXAHYDROISOQUINOLIN 2(1H)YL] 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHOXY 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 (6 CHLORO 1,2 DIHYDRO 2 OXOBENZO[D]IMIDAZOL 3 YL)PIPERIDIN 1YL] 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 (6 CHLORO 1,2 DIHYDRO 2 OXOBENZO[D]IMIDAZOL 3 YL)PIPERIDIN 1YL] 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [(4 CHLOROPHENYL)(PHENYL)METHYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [(4 CHLOROPHENYL)(PHENYL)METHYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [(BENZO[D][1,3]DIOXOL 5 YL)METHYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [(BENZO[D][1,3]DIOXOL 5 YL)METHYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 1,4 DIHYDRO 6 FLUORO 8 METHOXY 5 NITRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; DNA TOPOISOMERASE (ATP HYDROLYSING); FLUOROBENZENE; GATIFLOXACIN; ISONIAZID; LOMEFLOXACIN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ERYTHEMA; FEMALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHOTOTOXICITY; SINGLE DRUG DOSE; SUBSTITUTION REACTION; TUBERCULOSIS;

AMINATION; ANIMALS; ANTI-BACTERIAL AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CYCLOPROPANES; DNA GYRASE; FLUORINE COMPOUNDS; HYDROXYQUINOLINES; MOLECULAR STRUCTURE; MYCOBACTERIUM; PHOTOSENSITIZING AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 40749123967     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.050     Document Type: Article

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