Synthesis and antimycobacterial evaluation of various 7-substituted ciprofloxacin derivatives

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 20, 2005, Pages 5774-5778

  Sriram, Dharmarajan ^a   Yogeeswari, Perumal ^a   Basha, Jafar Sadik ^a   Radha, Deshpande R ^b   Nagaraja, Valakunja ^b  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Anti TB; Antimycobacterial; Ciprofloxacin derivatives; DNA gyrase inhibition

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 4 OXO 7 [[N(4) [1' (5 BROMOISATINYL BETA THIOSEMICARBAZO)]METHYL] N(1) PIPERAZINYL] 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 4 OXO 7 [[N(4) [1' (5 METHYLISATINYL BETA SEMICARBAZO)]METHYL] N(1) PIPERAZINYL] 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 4 OXO 7 [N(4) (ISATINYL)METHYL] N(1) PIPERAZINYL 3 QUINOLINE CARBOXYLIC ACID; ANTIMYCOBACTERIAL AGENT; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ISONIAZID; MOXIFLOXACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SPLEEN;

ANIMALS; ANTITUBERCULAR AGENTS; CIPROFLOXACIN; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; MAXIMUM TOLERATED DOSE; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 24344433207     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.05.063     Document Type: Article

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