Zinc, alpha cells and glucagon secretion

Current Diabetes Reviews

Volumn 6, Issue 1, 2010, Pages 52-57

  Egefjjord, Laerke ^a   Petersen, Andreas B ^a   Bak, Ann M ^a   Rungby, Jørgen ^a,b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

cells; Diabetes; Glucagon; Pancreas; Zinc transporters; Zn2+

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM ION; GLUCAGON; INSULIN; METALLOTHIONEIN; PYRUVIC ACID; STREPTOZOCIN; THIOL GROUP; VOLTAGE GATED CALCIUM CHANNEL; ZINC ION; ZINC TRANSPORTER;

ACTION POTENTIAL; ARTICLE; CALCIUM TRANSPORT; CELL ACTIVITY; CELL FUNCTION; CELL ISOLATION; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CELL METABOLISM; DEPOLARIZATION; DETOXIFICATION; ELECTRIC ACTIVITY; EXOCYTOSIS; GENETIC RISK; GLUCAGON RELEASE; GLUCOSE METABOLISM; HOMEOSTASIS; HYPOGLYCEMIA; IN VIVO STUDY; INHIBITION KINETICS; INSULIN RELEASE; MEMBRANE POTENTIAL; METAL BINDING; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PANCREAS; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; SECRETORY VESICLE; SIGNAL TRANSDUCTION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; CATION TRANSPORT PROTEINS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; GLUCAGON; GLUCAGON-SECRETING CELLS; HOMEOSTASIS; HUMANS; POTASSIUM CHANNELS; RATS; ZINC;

EID: 77950806808     PISSN: 15733998     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339910790442655     Document Type: Article

References (54)

1. Clifford KS, MacDonald MJ. Survey of mRNAs encoding zinc transporters and other metal complexes from birth to adulthood: similar patterns in the Spraque-Dawley and Wistar BB Strains. Diabetes Res Clin Pract 2000; 49: 77-85.
2. Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr 1998; 17: 109-115
3. Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev 1993; 73: 79-118.
4. Kim BJ, Kim YH, Kim S, et al. Zinc as a paracrine effector in pancreatic islet cell death. Diabetes 2000; 49: 367-372
5. Chang I, Cho N, Koh JY, Lee MS. Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes. Diabetologia 2003; 46: 1220-1227
6. Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Lakey JR, Rajotte RV. Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production. J Clin Endocrinol Metab 1996; 81: 3197-3202
7. Kinlaw WB, Levine AS, Morley JE, Silvis SE, McClain CJ. Abnormal zinc metabolism in type II diabetes mellitus. Am J Med 1983; 75: 273-277
8. Pai LH, Prasad AS. Abnormal zinc metabolism in type II diabetes mellitus. Nutr Res 1988; 8: 897-899
9. Søndergaard LG, Stoltenberg M, Flyvbjerg A, et al. Zinc ions in beta-cells of obese, insulin-resistant, and type 2 diabetic rats traced by autometallography. APMIS 2003; 111: 1147-1154
10. Garg VK, Gupta R, Goyal RK. Hypozincemia in diabetes mellitus. J Assoc Physicians India 1994; 42: 720-721
11. Roussel AM, Kerkeni A, Zouari N, Mahjoub S, Matheau JM, Anderson RA. Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. J Am Coll Nutr 2003; 4: 31621.
12. Ho E, Quan N, Tsai YH, Lai W, Bray TM. Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice. Exp Biol Med 2001; 226: 103-111
13. Chen MD, Song YM, Lin PY. Zinc effects on hyperglycemia and hypoleptinemia in streptozotocin-induced diabetic mice. Horm Metab Res 2000; 32: 107-109
14. Chimienti F, Seve M, Richard S, Mathieu J, Favier A. Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors. Biochem Pharmacol 2001; 62: 51-62.
15. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40: 405-412
16. 2+ induces permeability transition pore opening and release of proapoptotic peptides from neuronal mitochondria. Biol Chem 2001; 276: 47524-47529
17. Dineley KE, Richards LL, Votyakova TV, Reynolds IJ. Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria. Mitochondrion 2005; 1: 55-65.
18. + channels. Neuron 2004; 41: 351-365
19. Kambe T, Yamaguchi-Iwai Y, Sasaki R, Nagao M. Overview of mammalian zinc transporters. Cell Mol Life Sci 2004; 61: 49-68.
20. Cousins RJ, Liuzzi JP, Lichten LA. Mammalian zinc transport, trafficking, and signals. J Biol Chem 2006; 281: 24085-24089
21. Jeppesen JB, Larsen A, Jessen N, et al. Glucose and zinc-depletion stimulate beta cell expression of ZnT3, a zinc transporter, whereas ZnT3 KO mice have decreased beta cell capacity. Diabetologia 2007; 50: 207-208
22. Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni A. Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am Coll Nutr 2001; 20: 212-218
23. Chimienti F, Devergnas S, Pattou F, et al. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 2006; 119: 4199-4206
24. Baetens D, Malaisse-Lagae F, Perrelet A, Orci L. Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans. Science 1979; 206: 1323-1325
25. Gromada J, Franklin I, Wollheim CB. Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 2007; 28: 84-116.
26. Unger RH, Orchi L. The essential role of glucagon in the pathogenesis of diabete mellitus. Lancet 1975; 1: 14-16
27. Hutton JC, Penn EJ, Peshavaria M. Low-molecular-weight constituents of isolated insulin-secretory granules: bivalent cations, adenine nucleotides and inorganic phosphate. Biochem J 1989; 210: 297-305.
28. Foster MC, Leapman RD, Li MX, Atwater I. Elemental composition of secretory granules in pancreatic islets of Langerhans. Biophys J 1993; 64: 525-532
29. Qian WJ, Aspinwall CA, Battiste MA, Kennedy RT. Detection of secretion from single pancreatic beta-cells using extracellular fluorogenic reactions and confocal fluorescence microscopy. Anal Chem 2000; 72: 711-717
30. Hurley LS. Zinc deficiency in the developing rats. Am J Clin Nutr 1969; 22: 1332-1339
31. Göpel S, Zhang Q, Eliasson L, et al. Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J Physiol 2004; 556: 711-726
32. Priel T, Hershfinkel M. Zinc influx and physiological consequences in the beta-insulinoma cell line, Min6. Biochem Biophys Res Commun 2006; 346: 205-212
33. 2+ channel. J Biol Chem 2006; 281: 9361-9372
34. Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB. Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 2003; 5: 330-335
35. + AT channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol 2007; 5: 143.
36. 2+]c by different mechanisms in isolated mouse {alpha}-cells. Diabetes 2009; 58: 412-421
37. Rorsman P, Berggren PO, Bokvist K, et al. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature 1989; 341: 233-236
38. Gyulkhandanyan AV, Lu H, Lee SC, et al. Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells. J Biol Chem 2008; 283: 10184-10197
39. Maret W. The function of zinc metallothionein: a link between cellular zinc and redox state. Paper presented at the international workshop "Zinc and health: Current status and future directions", National Institutes of Health, Bethesda, MD, 4-5 November 1998.
40. Kang YJ. Metallothionein redox cycle and function. Exp Biol Med 2006; 9:1459-1467
41. Zhou H, Zhang T, Harmon JS, Bryan J, Robertson RP. Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Diabetes 2007; 56: 1107-1112
42. Sakurai H, Adachi Y. The pharmacology of the insulinomimetic effect of zinc complexes. Biometals 2005; 4: 319-323
43. Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB. Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 2005; 54: 1808-1815
44. Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB, Gromada J. Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology 2005; 146: 4861-4870
45. Leung YM, Ahmed I, Sheu L, et al. Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'- triphosphate inhibition. Endocrinology 2006; 147: 2155-2162
46. Vieira E, Salehi A, Gylfe E. Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells. Diabetologia 2007; 50: 370-379
47. Smidt K, Pedersen SB, Brock B, et al. Zinc-transporter genes in human visceral and subcutaneous adipocytes: lean versus obese. Mol Cell Endocrinol 2006; 264: 68-73.
48. Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445: 828-830
49. Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 317: 1035-1036
50. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316: 1341-1345
51. Wenzlau JM, Juhl K, Yu L, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2007; 104: 17040-17045
52. Egefjord L, Jensen JL, Bang-Berthelsen CH, et al. Zinc transporter gene expression is regulated by pro-inflammatory cytokines - A potential role for zinc transporters in beta-cell apoptosis? BMC Endocr Disord 2009; 9: 7.
53. Ravier MA, Rutter GA. Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes 2005; 54: 1789-1797
54. Kristiansen LH, Rungby J, Sendergaard LG, Stoltenberg M, Danscher G. Autometallography allows ultrastructural monitoring of zinc in the endocrine pancreas. Histochem Cell Biol 2001; 115: 125-129