A novel Ca2+/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor

Journal of Biological Chemistry

Volumn 285, Issue 33, 2010, Pages 25867-25874

  Jung, Hye Jin ^a   Kim, Jong Hyeon ^a   Shim, Joong Sup ^a   Kwon, Ho Jeong ^a  

^a Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ANTI-ANGIOGENIC ACTIVITY; BENZOIC ACID; CHICK EMBRYO; CHORIO-ALLANTOIC MEMBRANES; COMBINATION TREATMENTS; CURCUMIN; HYDROXAMIC ACIDS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTORS; IN-VITRO; IN-VIVO; MODE OF ACTION; NEOVASCULARIZATION; RAPAMYCIN; SINGLE-AGENT; SYNTHETIC CHEMICALS; TARGET GENES; TRANSCRIPTIONAL ACTIVITY; TUBE FORMATION; VASCULAR ENDOTHELIAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

CALMODULIN; CAMS; ENDOTHELIAL CELLS; GENE EXPRESSION; ORGANIC ACIDS; SELF ASSEMBLY;

CALCIUM;

4 [3,5 BIS [2 (4 HYDROXY 3 METHOXYPHENYL)ETHYL] 4,5 DIHYDROPYRAZOL 1 YL]BENZOIC ACID; CALMODULIN INHIBITOR; HYPOXIA INDUCIBLE FACTOR; RAPAMYCIN; TERPESTACIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VORINOSTAT; BENZOIC ACID; BICYCLO COMPOUND; CALCIUM; CALMODULIN; HYDROXAMIC ACID; HYPOXIA INDUCIBLE FACTOR 1;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG POTENCY; DRUG POTENTIATION; ENDOTHELIUM CELL; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; PRIORITY JOURNAL; RNA TRANSLATION; VASCULAR ENDOTHELIUM; ANIMAL; CELL LINE; CELL PROLIFERATION; CHEMISTRY; CHICKEN; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BENZOIC ACID; BICYCLO COMPOUNDS; BLOTTING, WESTERN; CALCIUM; CALMODULIN; CELL LINE; CELL PROLIFERATION; CHICKENS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROXAMIC ACIDS; HYPOXIA-INDUCIBLE FACTOR 1; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIROLIMUS;

EID: 77955493467     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.135632     Document Type: Article

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