Calmodulin is essential for angiogenesis in response to hypoxic stress in endothelial cells

Cell Biology International

Volumn 31, Issue 2, 2007, Pages 126-134

  Shen, Wei Gan ^a,b   Peng, Wan Xin ^a   Dai, Gu ^a   Xu, Jian Feng ^a   Zhang, Yu ^b   Li, Chao Jun ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b YANGZHOU UNIVERSITY   (China)

Author keywords

Actin; Angiogenesis; Ca2+ calmodulin; Hypoxia; Hypoxia inducible factor 1; Lamellipodia

Indexed keywords

ACTIN; CALMODULIN; CALMODULIN INHIBITOR; COLLAGEN TYPE 1; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANGIOGENESIS; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPOXIA; REGULATORY MECHANISM; VASCULAR ENDOTHELIUM;

ACTINS; CALCIUM SIGNALING; CALMODULIN; CELL ADHESION; CELL HYPOXIA; CELL MOVEMENT; COLLAGEN TYPE I; ENDOTHELIAL CELLS; GENE EXPRESSION; GENES, REPORTER; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN TRANSPORT; PSEUDOPODIA;

EID: 33846829583     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2006.09.017     Document Type: Article

References (36)

1. Annabi B., Thibeault S., Lee Y.T., Bousquet-Gagnon N., Eliopoulos N., Barrette S., et al. Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. Exp Hematol 31 (2003) 640-649
2. Annabi B., Lee Y.T., Turcotte S., Naud E., Desrosiers R.R., Champagne M., et al. Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation. Stem Cells 21 (2003) 337-347
3. Aono Y., Ariyoshi H., Sakon M., Ueda A., Tsuji Y., Kawasaki T., et al. Human umbilical vein endothelial cells (HUVECs) show Ca(2+) mobilization as well as Ca(2+) influx upon hypoxia. J Cell Biochem 78 (2000) 458-464
4. Arnould T., Michiels C., Alexandre I., and Remacle J. Effect of hypoxia upon intracellular calcium concentration of human endothelial cells. J Cell Physiol 152 (1992) 215-221
5. Ashton A.W., Yokota R., John G., Zhao S., Suadicani S.O., Spray D.C., et al. Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). J Biol Chem 274 (1999) 35562-35570
6. Auerbach R., Lewis R., Shinners B., Kubai L., and Akhtar N. Angiogenesis assays: a critical overview. Clin Chem 49 (2003) 32-40
7. Ceradini D.J., Kulkarni A.R., Callaghan M.J., Tepper O.M., Bastidas N., Kleinman M.E., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10 (2004) 858-864
8. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 6 (2000) 389-395
9. Chin D., and Means A.R. Calmodulin: a prototypical calcium sensor. Trends Cell Biol 10 (2000) 322-328
10. Dipp M., Nye P.C., and Evans A.M. Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle. Am J Physiol Lung Cell Mol Physiol 281 (2001) L318-L325
11. Eccles S.A. Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention. Int J Dev Biol 48 (2004) 583-598
12. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29 (2002) 15-18
13. Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
14. Harris A.L. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2 (2002) 38-47
15. Kayyali U.S., Pennella C.M., Trujillo C., Villa O., Gaestel M., and Hassoun P.M. Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2. J Biol Chem 77 (2002) 42596-42602
16. Keledjian K., and Kyprianou N. Anoikis induction by quinazoline based alpha 1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2. J Urol 169 (2003) 1150-1156
17. Leavesley D.I., Schwartz M.A., Rosenfeld M., and Cheresh D.A. Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol 121 (1993) 163-170
18. Lee H.T., and Kay E.P. FGF-2 induced reorganization and disruption of actin cytoskeleton through PI 3-kinase, Rho, and Cdc42 in corneal endothelial cells. Mol Vis 9 (2003) 624-634
19. Li Y., Lin J.L., Reiter R.S., Daniels K., Soll D.R., and Lin J.J. Caldesmon mutant defective in Ca(2+)-calmodulin binding interferes with assembly of stress fibers and affects cell morphology, growth and motility. J Cell Sci 117 (2004) 3593-3604
20. Malonne H., Langer I., Kiss R., and Atassi G. Mechanisms of tumor angiogenesis and therapeutic implications: angiogenesis inhibitors. Clin Exp Metastasis 17 (1999) 1-14
21. Mukhopadhyay D., and Akbarali H.I. Depletion of [Ca2+]i inhibits hypoxia-induced vascular permeability factor (vascular endothelial growth factor) gene expression. Biochem Biophys Res Commun 229 (1996) 733-738
22. Naito M., Hayashi T., Kuzuya M., Funaki C., Asai K., and Kuzuya F. Vascular endothelial cell migration in vitro roles of cyclic nucleotides, calcium ion and cytoskeletal system. Artery 17 (1989) 21-31
23. Pennacchietti S., Michieli P., Galluzzo M., Mazzone M., Giordano S., and Comoglio P.M. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3 (2003) 347-361
24. Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9 (2003) 677-684
25. 2+/calmodulin activity. Dig Dis Sci 47 (2002) 1008-1014
26. Raymond R., and Millhorn D. Regulation of tyrosine hydroxylase gene expression during hypoxia: role of Ca2+ and PKC. Kidney Int 51 (1997) 536-541
27. Ridley A.J. Rho GTPases and cell migration. J Cell Sci 114 (2001) 2713-2722
28. Ruggeri B.A., Robinson C., Angeles T., Wilkinson IV J., and Clapper M.L. The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth. Clin Cancer Res 8 (2002) 267-274
29. Salnikow K., Kluz T., Costa M., Piquemal D., Demidenko Z.N., Xie K., et al. The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol 22 (2002) 1734-1741
30. Salvaterra C.G., and Goldman W.F. Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytes. Am J Physiol 264 (1993) L323-L328
31. Semenza G.L. Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J Clin Invest 106 (2000) 809-812
32. Semenza G.L. Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance. J Clin Invest 108 (2001) 39-40
33. Seta K.A., Yuan Y., Spicer Z., Lu G., Bedard J., Ferguson T.K., et al. The role of calcium in hypoxia-induced signal transduction and gene expression. Cell Calcium 36 (2004) 331-340
34. Shibata T., Akiyama N., Noda M., Sasai K., and Hiraoka M. Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Int J Radiat Oncol Biol Phys 42 (1998) 913-916
35. Shimoda L.A., Sham J.S., Shimoda T.H., and Sylvester J.T. L-type Ca(2+) channels, resting [Ca(2+)] (i), and ET-1-induced responses in chronically hypoxic pulmonary myocytes. Am J Physiol Lung Cell Mol Physiol 279 (2000) L884-L894
36. Tamilarasan K.P., Kolluru G.K., Rajaram M., Indhumathy M., Saranya R., and Chatterjee S. Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells. BMC Cell Biol 7 (2006) 17