High-throughput screening system for identifying phototoxic potential of drug candidates based on derivatives of reactive oxygen metabolites

Pharmaceutical Research

Volumn 27, Issue 8, 2010, Pages 1610-1619

  Onoue, Satomi ^a   Ochi, Masanori ^a   Gandy, Graham ^b   Seto, Yoshiki ^a   Igarashi, Naoko ^c   Yamauchi, Yukinori ^d   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c CHIBA UNIVERSITY   (Japan)

^d MATSUYAMA UNIVERSITY   (Japan)

Author keywords

3T3 neutral red uptake phototoxicity test; derivatives of reactive oxygen metabolites; photogenotoxicity; phototoxicity; reactive oxygen species

Indexed keywords

ACETYLSALICYLIC ACID; AMIODARONE; BENZOCAINE; CARBAMAZEPINE; CHLORPROMAZINE; DICLOFENAC; DOXYCYCLINE; DRUG; ERYTHROMYCIN; FLUOROURACIL; FUROSEMIDE; IMIPRAMINE; INDOMETACIN; KETOPROFEN; METHOXSALEN; NALIDIXIC ACID; NAPROXEN; NEW DRUG; NITROFURANTOIN; NORFLOXACIN; OMEPRAZOLE; PHENYTOIN; PIROXICAM; PROMETHAZINE; QUINIDINE; QUININE; REACTIVE OXYGEN METABOLITE; SOLVENT; SULISOBENZONE; UNINDEXED DRUG; DNA; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; NEUTRAL RED; PERHYDROXYL RADICAL; PEROXIDE;

ACCURACY; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DNA CLEAVAGE; DNA DETERMINATION; DRUG DETERMINATION; DRUG RESEARCH; GENOTOXICITY; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; PHOTOSTIMULATION; PHOTOTOXICITY; PREDICTION; PRIORITY JOURNAL; REPRODUCIBILITY; 3T3 CELL LINE; ANIMAL; ATOMIC FORCE MICROSCOPY; CHEMISTRY; LIGHT; MEDICINAL CHEMISTRY; RADIATION RESPONSE; SPECTROPHOTOMETRY;

3T3 CELLS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DNA; HIGH-THROUGHPUT SCREENING ASSAYS; INDICATORS AND REAGENTS; LIGHT; MICE; MICROSCOPY, ATOMIC FORCE; NEUTRAL RED; PEROXIDES; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY;

EID: 77955473719     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0161-3     Document Type: Article

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