Drug-induced phototoxicity: An early in vitro identification of phototoxic potential of new drug entities in drug discovery and development

Current Drug Safety

Volumn 4, Issue 2, 2009, Pages 123-136

  Onoue, Satomi ^a   Seto, Yoshiki ^a   Gandy, Graham ^b   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Photoallergy; Photogenotoxicity; Photoirritation; Phototoxicity; Reactive oxygen species

Indexed keywords

AMLODIPINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIFUNGAL AGENT; ANTIGOUT AGENT; ANTIHISTAMINIC AGENT; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; BENZOYL PEROXIDE; CARDIOVASCULAR AGENT; CHLORPROMAZINE; DICLOFENAC; DIURETIC AGENT; DOXYCYCLINE; ENOXACIN; FLUOROURACIL; HERBACEOUS AGENT; NEUROLEPTIC AGENT; NEUTRAL RED; NONSTEROID ANTIINFLAMMATORY AGENT; NORFLOXACIN; OFLOXACIN; PHOTOSENSITIZING AGENT; QUINOLINE DERIVED ANTIINFECTIVE AGENT; REACTIVE OXYGEN METABOLITE; RETINOID; SULFONAMIDE; TETRACYCLINE DERIVATIVE; UNINDEXED DRUG; DRUG;

ASSAY; DIAGNOSTIC PROCEDURE; DNA CLEAVAGE; GEL ELECTROPHORESIS; GENOTOXICITY; HUMAN; IN VITRO STUDY; NONHUMAN; PHOTOALLERGY; PHOTODERMATOSIS; PHOTOIRRITATION; PHOTOTOXICITY; PREDICTION; PRIORITY JOURNAL; REVIEW; TOXICITY TESTING; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; CONTACT DERMATITIS; DRUG DEVELOPMENT; LIGHT; RISK ASSESSMENT; ULTRAVIOLET RADIATION;

DERMATITIS, PHOTOALLERGIC; DERMATITIS, PHOTOTOXIC; DRUG DISCOVERY; HUMANS; LIGHT; PHARMACEUTICAL PREPARATIONS; RISK ASSESSMENT; ULTRAVIOLET RAYS;

EID: 67849108402     PISSN: 15748863     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488609788173044     Document Type: Review

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