β1-adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 2, 2010, Pages

  Wang, Wei ^a,b   Zhang, Hongyu ^b   Gao, Hui ^b   Kubo, Hajime ^b   Berretta, Remus M ^b   Chen, Xiongwen ^b   Houser, Steven R ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 adrenergic receptor; 2a subunit; Ca2+ signaling; Mouse heart; Necrosis

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BETA 1 ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; DOBUTAMINE; ISOPRENALINE; NIFEDIPINE; REACTIVE OXYGEN METABOLITE; SODIUM CALCIUM EXCHANGE PROTEIN; ZINTEROL;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; IMMUNOFLUORESCENCE MICROSCOPY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; TRANSGENIC MOUSE; WILD TYPE;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANTIOXIDANTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; ISOPROTERENOL; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NECROSIS; PROTEIN SUBUNITS; REACTIVE OXYGEN SPECIES; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-CALCIUM EXCHANGER; TIME FACTORS;

EID: 77955437833     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00392.2010     Document Type: Article

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