Transgenic simulation of human heart failure-like L-type Ca 2+-channels: Implications for fibrosis and heart rate in mice

Cardiovascular Research

Volumn 84, Issue 3, 2009, Pages 396-406

  Beetz, Nadine ^a   Hein, Lutz ^a   Meszaros, Janos ^b   Gilsbach, Ralf ^a   Barreto, Frederico ^a   Meissner, Marcel ^c   Hoppe, Uta C ^b   Schwartz, Arnold ^d   Herzig, Stefan ^b   Matthes, Jan ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Arrhythmia; Cardiac fibrosis; Heart failure; Hypertrophy; L type calcium channel; Transgenic mice

Indexed keywords

8 BROMO CYCLIC AMP; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL L TYPE BETA2; OKADAIC ACID; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL CAV 1.2;

ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CALCIUM CURRENT; CHANNEL GATING; DISEASE EXACERBATION; GENE OVEREXPRESSION; HEART ARRHYTHMIA; HEART FAILURE; HEART HYPERTROPHY; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART RATE; HYPOTENSION; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIMULATION; STEADY STATE; TRANSGENE; TRANSGENIC MOUSE;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM CHANNELS, L-TYPE; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FIBROSIS; HEART FAILURE; HEART RATE; HUMANS; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; OKADAIC ACID; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS;

EID: 70849117791     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp251     Document Type: Article

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