Acute β-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells

Journal of Biological Chemistry

Volumn 282, Issue 15, 2007, Pages 11397-11409

  Ellison, Georgina M ^a,b   Torella, Daniele ^b,c   Karakikes, Ioannis ^a   Purushothaman, Saranya ^a   Curcio, Antonio ^c   Gasparri, Cosimo ^c   Indolfi, Ciro ^c   Cable, N Tim ^b   Goldspink, David F ^b   Nadal Ginard, Bernardo ^a,d  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; AMINES; CALCIUM; CELLS;

CARDIAC STEM CELLS; CATECHOLAMINE; ISOPROTERENOL (ISO);

CARDIOLOGY;

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; RYANODINE RECEPTOR 2; BETA ADRENERGIC RECEPTOR; CALCIUM; ISOPRENALINE; RYANODINE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE INJURY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; STEM CELL; SURVIVAL; ANIMAL; CELL DEATH; CHEMICALLY INDUCED DISORDER; CONGESTIVE HEART FAILURE; CYTOLOGY; DRUG EFFECT; METABOLISM; MUSCLE CELL; PATHOLOGY; PHOSPHORYLATION; TIME; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; CALCIUM; CELL DEATH; HEART FAILURE, CONGESTIVE; ISOPROTERENOL; MALE; MUSCLE CELLS; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; STEM CELLS; TIME FACTORS;

EID: 34249714164     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607391200     Document Type: Article

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