Inhibition of Na+/Ca2+ exchange by KB-R7943: Transport mode selectivity and antiarrhythmic consequences

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 3 50-3, 2001, Pages

  Elias, Chadwick L ^a   Lukas, Anton ^a   Shurraw, Sabin ^a   Scott, Jason ^a   Omelchenko, Alexander ^a   Gross, Gil J ^b   Hnatowich, Mark ^a   Hryshko, Larry V ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Electrophysiology; Giant excised patch clamp; NCX1.1; Sodium calcium

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; CALCIUM ION; SODIUM ION; 2 (2 (4 (4 NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; 2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; ANTIARRHYTHMIC AGENT; CALCIUM; DRUG DERIVATIVE; ISOPROTEIN; SODIUM; SODIUM CALCIUM EXCHANGE PROTEIN; THIOUREA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEART ARRHYTHMIA; ION EXCHANGE; ISOLATED HEART; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; RABBIT; REGULATORY MECHANISM; SODIUM CALCIUM EXCHANGE; XENOPUS LAEVIS; ANIMAL; BINDING COMPETITION; CELL CULTURE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROCARDIOGRAPHY; GENETICS; HEART; HEART LEFT VENTRICLE FUNCTION; IN VITRO STUDY; ION TRANSPORT; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; BINDING, COMPETITIVE; CALCIUM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART; ION TRANSPORT; MALE; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN ISOFORMS; RABBITS; REPERFUSION INJURY; SODIUM; SODIUM-CALCIUM EXCHANGER; THIOUREA; VENTRICULAR FUNCTION, LEFT; XENOPUS LAEVIS;

EID: 0034829226     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.3.h1334     Document Type: Article

References (53)

1. Relaxation in ferret ventricular myocytes: Role of the sarcolemmal Ca-ATPase
2. 2+ buffers
3. Sodium/calcium exchange: Its physiological implications
4. Ischemic preconditioning and arrhythmogenesis in the rabbit heart: Effects on epicardium versus endocardium
5. Na-Ca in cardiac myocytes
6. The effects of inhibition of the sarcolemmal Ca-ATPase on systolic calcium fluxes and intracellular calcium concentration in rat ventricular myocytes
7. Calcium extrusion during aftercontractions in cardiac myocytes: The role of the sodium-calcium exchanger in the generation of the transient inward current
8. 2+ exchanger in failing human myocardium
9. 2+ exchange in inside-out patches excised from guineapig ventricular myocytes
10. 2+ transient induced by angiotensin II in isolated adult rabbit ventricular myocytes
11. Sodium/calcium exchange contributes to contraction and relaxation in failed human ventricular myocytes
12. Sodium-calcium exchange: The phantom menace
13. 2+ exchange in giant excised sarcolemmal membrane patches
14. Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP
15. Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation
16. 2+ exchanger
17. 2+
18. Intracellular sodium accumulation during ischemia as the substrate for reperfusion injury
19. 2+ exchanger
20. 2+ exchanger isoforms by divalent cations and isothiourea derivative
21. 2+ exchange in cells expressing NCX1
22. 2+ exchange current by KB-R7943 in guinea-pig cardiac myocytes
23. 2+ exchanger cDNA
24. 2+ exchanger inhibitor, KB-R7943, caused negative inotropic responses and negative followed by positive chronotropic responses in isolated, blood-perfused dog heart preparations
25. Sarcoplasmic reticulum proteins in heart failure
26. 2+ exchanger (NCX1, NCX2, NCX3)
27. Transient inward current in guinea-pig atrial myocytes reflects a change of sodium-calcium exchange current
28. 2+ influx
29. Steady-state and dynamic properties of cardiac sodium-calcium exchange. Ion and voltage dependencies of the transport cycle
30. 2+-binding domain
31. ++ exchanger and myocardial ischemia/reperfusion
32. 2+ exchange in isolated guinea-pig cardiac myocytes
33. 2+ exchange, KB-R7943, on reoxygenation-induced injuries in guinea pig papillary muscles
34. 2+ exchange inhibitor, on myocardial ischemia/reperfusion injury
35. Molecular operations of the sodium-calcium exchanger revealed by conformation currents
36. 2+ overload by metabolic inhibition in guinea pig myocytes
37. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. I. Experimental studies
38. 2+ exchange: Characterization of the eight-state consecutive transport model
39. Sodium-calcium exchange: A molecular perspective
40. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure
41. 2+ homeostasis
42. 2+ overload in rat ventricular myocytes
43. On the characteristics of the inward tail current induced by calcium overload
44. 2+ exchanger protein levels in human heart failure
45. 2+ exchanger in end-stage human heart failure
46. 2+
47. The Lambeth Conventions: Guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion
48. 2+ exchange inhibitor, KB-R7943, on ouabain-induced arrhythmias in guinea-pigs
49. Calcium-dependent inhibition of the sodium-calcium exchange current by KB-R7943
50. 2+ exchange current in guinea-pig cardiac ventricular cells
51. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. II. Model studies
52. 2+ transient and contractility in rabbit ventricular myocytes: Pharmacological analysis with KB-R7943
53. 2+ homeostasis in rabbits with pacing-induced heart failure