Synthesis and pharmacology of 1-methoxy analogs of CP-47,497

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 15, 2010, Pages 5475-5482

  Huffman, John W ^a   Hepburn, Seon A ^a   Reggio, Patricia H ^b   Hurst, Dow P ^b   Wiley, Jenny L ^c   Martin, Billy R ^c  

^a CLEMSON UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

1 Methoxy cannabinoids; CB1 receptor; CB2 receptor; Nontraditional cannabinoids

Indexed keywords

2 (3 METHOXY 5 HYDROXYPHENYL) 2 METHYLHEPTANE; 2 (3 METHOXYPHENYL) 2 METHYLHEPTANE; 2 (4 BROMO 3 METHOXYPHENYL) 2 METHYLHEPTANE; 3 [2 HYDROXY 4 (1,1 DIMETHYLHEPTYL)PHENYL]CYCLOHEXANOL; 3 [2 METHOXY 4 (1,1 DIMETHYLHEPTYL)PHENYL]CYCLOHEXANOL; 3 [2 METHOXY 4 (1,1 DIMETHYLHEXYL)PHENYL]CYCLOHEX 2 EN 1 ONE; 3 [2 METHOXY 4 (1,1 DIMETHYLHEXYL)PHENYL]CYCLOHEXANOL; 3 [2 METHOXY 4 (1,1 DIMETHYLHEXYL)PHENYL]CYCLOHEXANONE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; JWH 324; JWH 342; JWH 440; JWH 4407; JWH 441; JWH 442; UNCLASSIFIED DRUG; CP 47497; CYCLOHEXANOL DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODEL; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; CHO CELL LINE; COMPUTER SIMULATION; CRICETULUS; HAMSTER; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING SITES; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; CYCLOHEXANOLS; HUMANS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955422523     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.054     Document Type: Article

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