Paradoxical pharmacological effects of deoxy-tetrahydrocannabinol analogs lacking high CB1 receptor affinity

Pharmacology

Volumn 66, Issue 2, 2002, Pages 89-99

  Wiley, Jenny L ^a   Jefferson, Renée G ^a   Griffin, Graeme ^a   Liddle, John ^b   Yu, Shu ^b   Huffman, John W ^b   Martin, Billy R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b CLEMSON UNIVERSITY   (United States)

Author keywords

Antinociception; Cannabinoids; Mice; SR144528; Structure activity relationship

Indexed keywords

5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; DEOXYTETRAHYDROCANNABINOL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LIGAND; RIMONABANT; SULFUR 35; TETRAHYDROCANNABINOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; HYPOTHERMIA; IN VIVO STUDY; MALE; MOBILIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR AFFINITY;

ANIMALS; BORNANES; CANNABINOIDS; MALE; MICE; MICE, INBRED ICR; PROTEIN BINDING; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

EID: 0036041537     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065631     Document Type: Article

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